DETERMINANTS OF PERCEPTUAL PERFORMANCE

知觉表现的决定因素

• 批准号: 3775267
• 负责人: DAVID W SMITH
• 金额: --
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775267
• 关键词: acoustic nerve; auditory discrimination; auditory threshold; behavior test; biophysics; cats; cochlear implants; cochlear lesion; conditioning; deafness; electric field; electrodes; electrophysiology; electrostimulus; ganglions; histology; loudness; neural degeneration; neural transmission; neuroanatomy; perception; performance; psychoacoustics; psychological models; single cell analysis; sound frequency

Project V is concerned with the behavioral analysis of the biophysical mechanisms underlying cochlear implant function. Behaviorally trained cats will be deafened unilaterally and implanted with an experimental 11- electrode point-source array. Auditory function under conditions of intracochlear electrical stimulation will be assessed using standard psychophysical paradigms to ascertain absolute threshold, loudness growth, dynamic range, and difference limens for frequency and intensity. Once trained, behavioral performance of a given animal on a given task will be determined for multiple electrical field coupling configurations. Following stabilization of an animal's behavioral performance, electrophysiological recordings of single-cell activity will be obtained in acute experiments, using the same stimuli and testing paradigms that had been employed behaviorally. Animals will then be sacrificed, and their cochleas will be processed histologically to determine the number and spatial positions of surviving spiral ganglion cells. The behavioral, physiological and anatomic data will then be merged and analyzed in the context of neural-behavioral models designed to account for perceptual performance on the basis of patterns of neural activity and tailored to reflect the anatomic condition of the spiral ganglion in the tested animal.

V项目与生物物理的行为分析有关 人工耳蜗功能的基础机制。 受行为训练的猫 将单方面聋，并用实验11-植入 电极点源阵列。 在条件下的听觉功能 将使用标准评估2条电气电刺激 心理物理范式以确定绝对阈值，响度增长， 动态范围和频率和强度的差异有限。 一次 受过训练的给定动物在给定任务上的行为表现将是 确定多个电场耦合配置。 稳定动物的行为表现后， 单细胞活性的电生理记录将在 急性实验，使用具有相同的刺激和测试范例 在行为上被雇用。 然后将牺牲动物，他们的 Cochleas将在组织学上进行处理，以确定数量和 存活的螺旋神经节细胞的空间位置。 行为， 然后将合并生理和解剖学数据 神经行为模型的背景旨在说明感知 根据神经活动的模式进行性能，并量身定制 反映已测试动物中螺旋神经节的解剖状况。