DETERMINANTS OF PERCEPTUAL PERFORMANCE

知觉表现的决定因素

• 批准号: 3775267
• 负责人: DAVID W SMITH
• 金额: --
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775267
• 关键词: acoustic nerve; auditory discrimination; auditory threshold; behavior test; biophysics; cats; cochlear implants; cochlear lesion; conditioning; deafness; electric field; electrodes; electrophysiology; electrostimulus; ganglions; histology; loudness; neural degeneration; neural transmission; neuroanatomy; perception; performance; psychoacoustics; psychological models; single cell analysis; sound frequency

Project V is concerned with the behavioral analysis of the biophysical mechanisms underlying cochlear implant function. Behaviorally trained cats will be deafened unilaterally and implanted with an experimental 11- electrode point-source array. Auditory function under conditions of intracochlear electrical stimulation will be assessed using standard psychophysical paradigms to ascertain absolute threshold, loudness growth, dynamic range, and difference limens for frequency and intensity. Once trained, behavioral performance of a given animal on a given task will be determined for multiple electrical field coupling configurations. Following stabilization of an animal's behavioral performance, electrophysiological recordings of single-cell activity will be obtained in acute experiments, using the same stimuli and testing paradigms that had been employed behaviorally. Animals will then be sacrificed, and their cochleas will be processed histologically to determine the number and spatial positions of surviving spiral ganglion cells. The behavioral, physiological and anatomic data will then be merged and analyzed in the context of neural-behavioral models designed to account for perceptual performance on the basis of patterns of neural activity and tailored to reflect the anatomic condition of the spiral ganglion in the tested animal.

项目 V 涉及生物物理的行为分析 人工耳蜗植入功能的机制。 经过行为训练的猫 将被单方面致聋并植入实验性11- 电极点源阵列。 条件下的听觉功能 耳蜗内电刺激将使用标准进行评估 确定绝对阈值、响度增长的心理物理学范式， 动态范围以及频率和强度的差异阈值。 一次 经过训练的特定动物在特定任务上的行为表现将 确定用于多个电场耦合配置。 动物行为表现稳定后， 单细胞活动的电生理记录将在 急性实验，使用与之前相同的刺激和测试范式 行为上受到雇佣。 然后动物将被献祭，他们的 耳蜗将进行组织学处理以确定数量和 存活螺旋神经节细胞的空间位置。 行为上， 然后，生理和解剖数据将被合并并分析 旨在解释感知的神经行为模型的背景 基于神经活动模式的性能并针对 反映受试动物螺旋神经节的解剖状况。