Controlling the function of pore forming perforin-like proteins in immune mediated disease

控制免疫介导疾病中成孔穿孔素样蛋白的功能

• 批准号: nhmrc : GNT1154184
• 负责人: Prof James Whisstock
• 金额: $ 88.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/controlling-function-pore-mediated-disease/1349122
• 关键词: Controlling; function; pore; forming; perforin; Controlling; function; pore; forming; perforin

The goal of this fellowship is to deploy sophisticated imaging workflows, and in particular electron microscopy, to understand how a major family of pore forming immune proteins functions to destroy target cells. The outcomes the fellowship will include basic discoveries that relate to how the immune system recognises and destroys foreign targets, and the the development of new inhibitors of the immune response that I anticipate will have future therapeutic value.

该团契的目的是部署复杂的成像工作流程，尤其是电子显微镜，以了解如何形成免疫蛋白的主要毛孔家族来破坏靶细胞。奖学金的结果将包括与免疫系统如何认识和破坏外国目标的基本发现，以及我预期的免疫反应的新抑制剂的发展将具有未来的治疗价值。