WickedSchisto: Developing an robust interdisciplinary-informed WASH framework for the wicked public-health problem of schistosomiasis

WickedSchisto：针对血吸虫病这一邪恶的公共卫生问题，开发一个强大的跨学科 WASH 框架

• 批准号: EP/X027082/1
• 负责人: Poppy Lamberton
• 金额: $ 273.66万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX027082%2F1
• 关键词: WickedSchisto; Developing; robust; interdisciplinary; informed

Over 240 million people have schistosomiasis, a debilitating disease intrinsically linked to inadequate water, sanitation and hygiene (WASH). A wicked problem is a social or cultural problem that is difficult or impossible to solve. Despite extensive mass drug administration (MDA), schistosomiasis remains a wicked public-health problem. WASH-interventions are needed to reach the World Health Organization (WHO) 2030 goal of elimination as a public-health problem. Yet we don't understand the full impact of schistosomiasis, and therefore cannot identify what feasible and cost-effective WASH interventions best reduce this impact, nor the threats to long-term control programme success, and how to mitigate these. I will address five ambitious questions:1. What are the true health, economic and societal impacts of schistosomiasis?2. What are the most cost-effective combinations of WASH and MDA interventions?3. How best can we scale-up these public-health WASH interventions to reach WHO 2030 goals?4. What are the risks from human mobility to achieving and sustaining WHO 2030 goals?5. How can cross-sectorial policy buy-in be leveraged to help reach these goals?I will use innovative interdisciplinary methods to tackle this wicked public-health problem including: an unprecedented, bottom-up approach to identify acceptable, equitable, cost-effective, feasible, multifaceted interventions with highest 'value for money' and impact on schistosomiasis health-related quality of life; develop a field-based morbidity marker to monitor success; combine state-of-the-art parasite genomics with mathematical models to inform on control programme endpoints; and identify community, through to international level, facilitators to leverage for intervention success. My pioneering research will inform policymakers in Uganda and beyond on how best to eliminate schistosomiasis. I will fill a critical global-health knowledge gap and provide a framework for other WASH-associated diseases.

超过2.4亿人患有血吸虫病，这是一种使人衰弱的疾病，与水，卫生和卫生（WASH）本质上有关。一个邪恶的问题是一个难以解决或无法解决的社会或文化问题。尽管广泛的大规模药物管理局（MDA），血吸虫病仍然是一个邪恶的公共卫生问题。需要洗涤干扰才能到达世界卫生组织（WHO）2030淘汰目标作为公共卫生问题。然而，我们不了解血吸虫病的全部影响，因此无法确定哪种可行且具有成本效益的洗手干预措施最能降低这种影响，也无法对长期控制计划成功的威胁以及如何减轻这些影响。我将解决五个雄心勃勃的问题：1。血吸虫病的真正健康，经济和社会影响是什么？2。 WASH和MDA干预措施的最具成本效益的组合是什么？3。我们如何最好地扩大这些公共卫生洗手干预措施，以达到2030年谁的目标？4。从人类流动性到达到2030年目标的人的风险是什么？5。如何利用跨部门的政策买入来帮助实现这些目标？我将使用创新的跨学科方法来解决这个邪恶的公共卫生问题，包括：一种前所未有的自下而上的方法，以识别可接受的，公平的，具有成本效益，具有成本效益，有效，可行的，多方面的干预措施，具有最高的“物资价值”，并对与健康相关的血吸虫病生活质量产生影响；开发基于现场的发病率标记来监测成功；将最新的寄生虫基因组学与数学模型相结合，以告知控制程序终点；并确定社区，直到国际水平，促进者利用干预成功。我的开创性研究将为乌干达的决策者以及如何最好地消除血吸虫病。我将填补关键的全球健康知识差距，并为其他洗涤相关疾病提供框架。