PHYSIOLOGY OF BONE METABOLISM IN AN AGING POPULATION

老龄化人群骨代谢的生理学

• 批准号: 3090941
• 负责人: B. LAWRENCE RIGGS
• 金额: $ 80.77万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3090941
• 关键词: aging; osteoporosis; aging; osteoporosis

Because of its high incidence and because of its devastating socioeconomic consequences, involutional osteoporosis is one of the most important disorders affecting the aging population. The disease causes 1.3 million fractures, including 240,000 hip fractures, each year. Almost one-third of women over age 65 years will have had vertebral fractures. The lifetime risk of hip fracture is 15% in women and 5% in men. Fifty percent of survivors cannot walk independently afterwards, and 25 to 50% are committed to long-term nursing home care. Overall costs of osteoporosis are estimated as $7 to $10 billion annually in the United States. In order to treat and to prevent this disorder we need 1) to know more about basic physiologic mechanisms regulating bone cell function, 2) to elucidate the mechanisms of disordered regulation of bone cell function in osteoporosis, 3) to define more sharply clinical risk factors for fractures, and 4) to find a safe and effective means of prevention that would be widely used by the general population of aging women. To accomplish these aims is our overall goal. The Program Project contains four independent research components and an administrative and biostatistical core. Project 1, "Pathophysiology of Osteoporosis," is the clinical investigation component. It tests the hypothesis that the disease results from impaired production of several systemic and local bone cell regulatory factors or from impaired response to them. We will search for abnormalities of systemic regulatory factors and, by testing cultured human bone cells, will assess possible local abnormalities of bone cell regulation for the first time in the study of osteoporosis. Project 2, "Record Studies of Hip Fractures" is the epidemiology component. It features a series of unique population-based retrospective (non-current, historical) cohort studies designed to determine the incidence of hip and various other age-related fractures and identify risk factors for them. In specified cohorts of patients with the risk factor, the incidence of fracture will be compared with the expected incidence rates in the community population. Project 3, "Regulation of Bone Cell Function," is the basic science component. It uses cell biology and molecular biology techniques to evaluate the effect and mechanism of action of sex steroids and growth factors on cultured normal human osteoblast-like cells. Project 4, "Preventive Therapy with Calcium," is the clinical trial component. It is designed to determine if bone loss in elderly women can be prevented or reduced by calcium supplementation as is suggested by our preliminary data.

由于其发病率很高，而且由于它的毁灭性 社会经济后果，涉嫌骨质疏松症是最大的一种 影响人口老龄化的重要疾病。 疾病引起的 每年有130万骨折，包括240,000个髋部骨折。 几乎有65岁以上的妇女中有三分之一将有椎骨 断裂。 髋部骨折的终生风险为15％，5％ 男人。 50％的幸存者之后无法独立行走， 25％至50％致力于长期疗养院护理。 全面的 骨质疏松症的成本估计为每年7至100亿美元 美国。 为了治疗和预防这种疾病，我们需要 1）了解有关调节骨细胞的基本生理机制的更多信息 功能，2）阐明无序调节机制 骨质疏松症中的骨细胞功能，3）定义更明显的临床 裂缝的危险因素，以及4）找到安全有效的手段 一般衰老人群将广泛使用的预防 女性。 实现这些目标是我们的总体目标。 该程序 项目包含四个独立的研究组件，一个 行政和生物统计核心。 项目1，“ 骨质疏松症，“是临床研究成分。它测试了 假设该疾病是由于生产受损而引起的 系统性和局部骨细胞调节因素或受损 对他们的回应。 我们将搜索系统性异常 调节因素以及通过测试培养的人骨细胞将 评估骨细胞调节的局部异常 首次研究骨质疏松症。 项目2，“记录研究 髋部骨折是流行病学成分。它具有一系列 独特的基于人群的回顾性（非流动，历史）队列 旨在确定髋关节和各种其他的研究 与年龄相关的裂缝并确定其风险因素。 在指定 具有危险因素的患者队列，骨折的发生率将 与社区的预期发病率进行比较 人口。 项目3，“骨细胞功能的调节”是基本的 科学组成部分。 它使用细胞生物学和分子生物学 评估性别作用的效果和机理的技术 类固醇和生长因子对培养的正常人成骨细胞样 细胞。 项目4，“钙的预防疗法”是临床 试用部分。 它旨在确定老年人是否骨质流失 可以通过补充钙来预防或减少妇女 由我们的初步数据建议。