High Throughput Preparation of Tuneable Magnetically Assembled 1D Nanostructures

可调谐磁组装一维纳米结构的高通量制备

基本信息

批准号：
EP/T026014/1
负责人：
Gemma-Louise Davies
金额：
$ 54.51万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FT026014%2F1
关键词：
Throughput Preparation Tuneable Magnetically Assembled

项目摘要

Development of technological advances is important in the continually growing nanotechnology market, which is set to exceed $125 billion within the next five years. 1-dimensional (1D) nanostructures, possessing one dimension outside the nanoscale (<100 nm) range, are typically nanowires, nanofibers and nanotubes, and occupy a significant portion of this fast-growing market due to their application in sectors ranging from batteries to biomedicine. Magnetic 1D materials have become particularly popular in recent years, as their large aspect ratio and 1D structure gives rise to anisotropy, which can produce orientated electronic and ionic transport and unusual anisotropic optical and magnetic properties. As a result of these properties, magnetic 1D materials have found application in magnetic recording, lithium ion batteries, sensors, catalysis and medicine. Such 1D materials can outperform their nanoparticle (or 0-dimensional, 0D) counterparts in many applications, for example in medicine, where anisotropy leads to increased magnetisation and local magnetic field strengths. This provides improved performance in medical imaging techniques such as magnetic resonance imaging (MRI), where 1D materials boost signal enhancement compared to their 0D analogues thanks to the increased anisotropy of their 1D structures. A number of new fabrication techniques for 1D materials have hence been pioneered and developed, including templating, bottom-up growth, lithography, electrospinning, and particle assembly, though these often suffer from poor tuneability of the resulting structures, and hence properties, as well as challenges with scalability - issues which are critical for their long-term use and industrial uptake. Magnetic interactions have long been used to generate colloidal structures which respond readily to a magnetic field, with ferrofluids being the most well-known example. The preparation of permanent 1D materials using magnetic assembly approaches has been explored recently, with clusters of magnetic nanoparticles being assembled into permanent arrays of nanowires or nanotubes either during synthesis, or through magnetically stimulated nanoparticle assembly. Although successfully forming 1D nanostructures, these approaches suffer from difficulties in controlling the resulting materials' size, aspect ratio and surface chemistry. There is, therefore, a clear need for a technique capable of reproducibly fabricating magnetic 1D nanostructures with controlled and tuneable aspect ratios, sizes and surfaces, at high scales. In this proposal, we aim to achieve this through the exploitation of continuous flow technology combined with magnetic assembly to produce core-shell 1D nanostructured materials with various coatings, which can be modified with ease for numerous different applications. This work will systematically explore the effect of flow rate, magnetic field strength and duration, magnetic nanoparticle building blocks and various coating agents in order to form a library of 1D materials whose properties are tuneable and reproducible.In this way, we will develop a novel, high throughput approach to magnetic 1D nanomaterials which will have precision control over structure, aspect ratio, surfaces and hence resulting properties of the 1D materials, in addition to the benefits of scalability that come with fluid flow systems. As a case study, the produced materials will be tested for their performance as contrast agents in magnetic resonance imaging (MRI). Using state-of-the-art magnetic resonance imaging tools, quantitative assessment of performance will demonstrate the benefits of tuneable 1D materials in this important medical application.

在不断增长的纳米技术市场中，技术进步的发展非常重要，该市场在未来五年内将超过1,250亿美元。一维（1D）纳米结构，在纳米级（<100 nm）范围之外具有一维的纳米结构通常是纳米线，纳米纤维和纳米管，并且由于其在炮台到生物疗法的部门的应用而占据了这个快速增长的市场的很大一部分。近年来，磁性1D材料已变得特别流行，因为它们的较大纵横比和1D结构会产生各向异性，这会产生定向的电子和离子传输以及异常的各向异性光学和磁性。由于这些特性，磁性1D材料已在磁记录，锂离子电池，传感器，催化和药物中应用。这样的一维材料在许多应用中，例如在医学中，各向异性导致磁性增加和局部磁场强度增加的纳米颗粒（或0维，0D）的表现。这提供了医学成像技术（例如磁共振成像（MRI））的改进性能，由于其1D结构的各向异性增加，因此，与0D类似物相比，一维材料增强了信号的增强。因此，许多针对1D材料的新制造技术已经开发和开发，包括模板，自下而上的生长，光刻，光刻，静电纺丝和颗粒组装，尽管这些通常遭受了所得结构的可调性较差，因此属性以及挑战以及具有长期使用和工业用途至关重要的挑战。长期以来，磁相互作用一直用于生成胶体结构，这些胶体结构容易响应磁场，而铁体流体是最著名的例子。最近已经探索了使用磁化装配方法制备永久性1D材料，在合成过程中或通过磁性刺激的纳米粒子组装组装，将磁性纳米颗粒簇组装成纳米线或纳米管的永久阵列。尽管成功形成了1D纳米结构，但这些方法在控制所得材料的尺寸，纵横比和表面化学方面遇到了困难。因此，清楚地需要一种能够在高尺度上可重复制造具有控制且可调纵横比，尺寸和表面的磁性1D纳米结构的技术。在此提案中，我们旨在通过开发连续流动技术与磁组件结合使用各种涂料来生产核心壳的1D纳米结构材料，从而实现这一目标，可以轻松修改许多不同的应用。这项工作将系统地探索流量，磁场强度和持续时间，磁性纳米颗粒的构件和各种涂层剂的影响流体流系统带来的可伸缩性。作为案例研究，将对产生的材料作为磁共振成像（MRI）中的对比剂进行测试。使用最先进的磁共振成像工具，对性能的定量评估将证明可调1D材料在这一重要的医疗应用中的好处。