Underpinning Equipment for Magnetic Resonance Research

磁共振研究的基础设备

基本信息

批准号：
EP/P030491/1
负责人：
Simon Spearing
金额：
$ 254.73万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FP030491%2F1
关键词：
Underpinning Equipment Magnetic Resonance Research

项目摘要

Nuclear Magnetic Resonance (NMR) is a technique which uses the fact that the nuclei of many atoms act as tiny radio-transmitters, emitting radio signals at precisely-defined frequencies, which can be detected by a carefully-tuned detector. In an NMR experiment, the nuclei are first magnetised by placing a sample in a strong magnetic field for some time. A sequence of radiofrequency pulses is then applied to the sample, which subsequently emits radiowaves which are detected in the radio receiver. The pattern of emitted waves provides information on the chemical composition and spatial distribution of the sample. One application of NMR is called Magnetic Resonance Imaging (MRI). This is used in hospitals to construct images of the interior of the human body, and is enormously useful for the diagnosis of diseases and injuries. The magnetic resonance research centre of the University of Southampton is a world-leading facility for NMR and MRI research development. We are currently developing techniques which enhance NMR signals by factors of many thousands, which may lead to methods for the clinical detection and diagnosis of cancer by MRI, as well as numerous other applications in materials science, biochemistry, analytical chemistry, and quantum physics. The user group is growing rapidly in size, as is the range of research activities and collaborations. Our core research portfolio is supported by grants mostly from EPSRC, the Royal Society, and the EU Commission, with a total value in excess of £8M. These include recent awards of a £1.8M EPSRC Platform Grant and a £2.9M award from the EU Commission under the extremely competitive Future and Emerging Technologies - Open (FETopen) scheme. This proposal seeks funding for upgrading NMR spectrometers that underpin cutting-edge research in magnetic resonance spectroscopy and imaging at the University of Southampton. Funds are requested for (i) the replacement of an ageing and obsolete 400MHz NMR console by a modern system; (ii) replacement of a second ageing 400MHz NMR console by a modern 700MHz system; (iii) provision of a workhorse 400MHz NMR console to enhance the productivity and capabilities of our homebuilt equipment which is capable of enhancing NMR signals by large factors. We will reuse our existing NMR magnets so as to keep costs down. These upgrades and replacements will being our research facility up to the international standard and significantly enhance our capability to perform, expand, and apply our cutting-edge research capabilities, in a highly cost-effective manner.

核磁共振 (NMR) 是一种利用许多原子核充当微小无线电发射器的技术，以精确定义的频率发射无线电信号，这些信号可以在 NMR 实验中被仔细调谐的探测器检测到。，首先将样品置于强磁场中一段时间，然后将一系列射频脉冲施加到样品上，样品随后发射无线电波，无线电接收器可以检测到发射波的模式，从而提供信息。 NMR 的一种应用称为磁共振成像 (MRI)，它在医院中用于构建人体内部的图像，对于疾病的诊断和诊断非常有用。南安普顿大学的磁共振研究中心是世界领先的 NMR 和 MRI 研究开发设施，我们目前正在开发将 NMR 信号增强数千倍的技术，这可能会导致临床检测和损伤的方法。通过 MRI 进行癌症诊断，如以及材料科学、生物化学、分析化学和量子物理学领域的众多其他应用，用户群体的规模正在迅速扩大，我们的核心研究组合主要得到 EPSRC（EPSRC）的资助。英国皇家学会和欧盟委员会的总价值超过 800 万英镑，其中包括最近授予的 180 万英镑 EPSRC 平台拨款以及欧盟委员会在竞争极其激烈的未来和新兴技术 - 开放项目下授予的 290 万英镑。 (FETopen) 计划寻求资助南安普顿大学核磁共振波谱仪的升级，以支持核磁共振波谱和成像的前沿研究。现代系统；(ii) 用现代 700MHz 系统替换第二台老化的 400MHz NMR 控制台；(iii) 提供主力 400MHz NMR 控制台，以增强我们自制设备的生产力和能力能够在很大程度上增强核磁共振信号，我们将重复利用现有的核磁共振磁体，以降低成本，这些升级和更换将使我们的研究设施达到国际标准，并显着提高我们的研究能力。以极具成本效益的方式执行、扩展和应用我们的尖端研究能力。