Detecting bladder volume and pressure from sacral nerve signals: the key to future artificial control

从骶神经信号检测膀胱容量和压力：未来人工控制的关键

• 批准号: EP/P018947/1
• 负责人: John Taylor
• 金额: $ 40.38万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP018947%2F1
• 关键词: Detecting; bladder; volume; pressure; sacral

This project is about the treatment of urinary incontinence, consequent of damage to the spinal cord. Managing the urinary bladder is of the first importance to clinicians and patients following trauma to the spinal cord. Historically, kidney damage due to high bladder pressures and/or infection was the usual cause of death resulting from such an injury. Infections still raise mortality and morbidity, exacerbated by the risk of antibiotic resistance. In order to achieve urination-i.e. complete voluntary micturition (CVM) and as an alternative to the expensive process of intermittent sterile catheterisation, a neuroprosthesis for controlling the bladder after spinal cord injury (SCI) was developed by GS Brindley at the MRC Neurological Prostheses Unit in London 30 years ago. The Brindley method employs sacral anterior root stimulation (SARS) but is not popular in Europe, in terms of the fraction of the SCI population treated, because implantation of the device is accompanied by cutting the sacral posterior (sensory) nerve roots (rhizotomy) to prevent reflex incontinence during bladder filling and improve stimulated voiding. Clearly there is a need for a new neuroprosthesis that is more widely acceptable (primarily because no rhizotomy is necessary) and which, in addition, reduces the lifetime cost of care. The aim of this project is to design and demonstrate such a device. Since its introduction, the Brindley method has been improved in several ways in attempts to address the problems mentioned. However, in spite of these developments, at present (a) no satisfactory, practical method exists for detecting the onset of bladder contractions in a chronic implant and, (b) no method is available to inform the patient of the level of bladder fullness to indicate when the bladder should be emptied. These are critical obstacles to the design of a complete prosthesis and our proposed solution is to use the bladder neural signals themselves since surgically implanted electrodes are essential anyway (i.e. for stimulation). A suitable site for the electrodes is the extradural roots; this is surgically attractive and electrodes are routinely implanted here in the Brindley procedure. In order that the nerves are similar to those in man, it is essential to use a large experimental animal as a preclinical model and we propose to use sheep for these experiments.

该项目是关于尿失禁的治疗，这是由于对脊髓的损害而造成的。对脊髓创伤后的临床医生和患者，管理膀胱是最重要的。从历史上看，由于膀胱压力高和/或感染而造成的肾脏损害是造成这种伤害造成的死亡原因。感染仍然会增加死亡率和发病率，这会因抗生素耐药性的风险加剧。为了达到排尿-I.E。 GS Brindley在30年前的MRC神经系统proship the MRC神经系统proshiphe开发了完整的自愿预动作（CVM），作为昂贵的间歇性无菌导管插入式昂贵的替代过程，用于控制脊髓损伤（SCI）后的神经假体。 Brindley方法采用s骨前根刺激（SARS），但就治疗的SCI种群的比例而言，在欧洲不流行，因为该装置的植入伴随着切割骨后（感觉）神经根（Rhizotomy）到防止在膀胱填充过程中反射尿失禁，并改善刺激的空隙。显然，需要一种更广泛可接受的新神经假设（主要是因为不需要根茎切开术），并且还降低了终身护理成本。该项目的目的是设计和演示这种设备。自引入以来，Brindley方法已通过多种方式改进，以解决提到的问题。但是，尽管存在这些事态发展，目前（a）尚无令人满意的实用方法来检测慢性植入物中膀胱收缩的发作，并且（（b）（b）没有任何方法可用于告知患者膀胱饱满度的水平指出何时应清空膀胱。这些是设计完整假体的关键障碍，我们提出的解决方案是使用膀胱神经信号本身，因为无论如何手术植入电极都是必不可少的（即刺激）。电极的合适部位是内膜根。这是手术吸引力的，电极通常在Brindley手术中植入。为了使神经与人类中的神经相似，必须使用大型实验动物作为临床前模型，我们建议将绵羊用于这些实验。

项目成果

Urinary Bladder Innervation within the Sacral Roots of a Sheep

羊骶根部膀胱的神经支配

• DOI: 10.1109/ner49283.2021.9441117
• 发表时间: 2021
• 作者: Metcalfe B

The Design of a Low Noise, Multi-Channel Recording System for Use in Implanted Peripheral Nerve Interfaces.

• DOI: 10.3390/s22093450
• 发表时间: 2022-04-30
• 期刊: Sensors (Basel, Switzerland)

A dataset of action potentials recorded from the L5 dorsal rootlet of rat using a multiple electrode array.

• DOI: 10.1016/j.dib.2020.106561
• 发表时间: 2020-12
• 期刊: Data in brief
• 影响因子: 1.2
• 作者: Metcalfe B;Hunter A;Graham-Harper-Cater J;Taylor J
• 通讯作者: Taylor J

The Effects of the Presence of Multiple Conduction Velocities in the Analysis of Electrically-Evoked Compound Action Potentials (eCAPs).

多个传导速度的存在对电诱发复合动作电位 (eCAP) 分析的影响。

• DOI: 10.1109/embc44109.2020.9175953
• 发表时间: 2020
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Taylor J

CMOS Analogue Velocity-Selective Neural Processing System

CMOS 模拟速度选择神经处理系统

• DOI: 10.3390/electronics13030569
• 发表时间: 2024
• 期刊: Electronics
• 影响因子: 2.9
• 作者: Sadrafshari S