Quantification of vascular and neuronal pathology in dementia using PET and MRI

使用 PET 和 MRI 对痴呆症的血管和神经病理学进行量化

基本信息

批准号：
EP/M005909/1
负责人：
Geoff Parker
金额：
$ 140.16万
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM005909%2F1
关键词：
Quantification vascular neuronal pathology dementia

项目摘要

The increasing occurrence of dementia within our ageing population is one of the pressing challenges facing society. Successful management of patients with dementia is significantly aided by early and accurate diagnosis. Imaging methods such as magnetic resonance imaging (MRI) and positron emission tomography (PET) are already used in the diagnostic process; we believe that there is substantial scope for both methods to be improved to provide more precise and sensitive diagnostic information, and to do so in a way that is easily tolerated by patients. If we are correct in this belief, then the methods we develop within this project will not only help in early diagnosis, but may also help in the discovery of new therapies and in the longer term with helping doctors select the best therapeutic strategies for patients with different forms of dementia.Imaging methods such as MRI and PET can tell us a lot more about brains than simply providing a picture of brain shape and size. We will focus on improving MRI and PET to be sensitive to two important microscopic aspects of dementia. Firstly, we will develop and validate new methods for measuring the loss of brain cells due to the condition; this loss is the cause of many of the symptoms of dementia, such as memory problems, and we hope to be able to detect these changes earlier than has previously been possible. Secondly we will develop and validate new methods for measuring changes in blood delivery to the brain and how this can affect oxygen delivery. These changes are thought to be part of one of the important processes involved in causing cell death and tissue loss, and are likely to be particularly relevant to vascular dementia.We will also spend considerable time checking that the measurements we develop are both accurate and practical for application in dementia patients in the future. We will optimise the way in which the scanning processes take place so that the time required for patients to lie in the scanner(s) is minimised. This will be important for future adoption of these methods in the clinical environment.

我们老龄化人口中痴呆症的发生是社会面临的紧迫挑战之一。通过早期和准确的诊断，成功治疗痴呆症患者。诊断过程中已经使用了诸如磁共振成像（MRI）和正电子发射断层扫描（PET）之类的成像方法。我们认为，可以改进两种方法以提供更精确和敏感的诊断信息，并以患者易于耐受的方式进行实质性的范围。如果我们在这种信念上是正确的，那么我们在该项目中开发的方法不仅可以在早期诊断方面有助于发现新疗法，而且从长远来看，可以帮助医生为具有不同形式的痴呆方法的患者选择最佳的治疗策略，例如MRI和PET等大脑，您可以对大脑进行更多的了解，而不是简单地提供大脑形状和大脑形状的图片。我们将专注于改善MRI和PET对痴呆症的两个重要显微镜方面敏感。首先，我们将开发并验证新方法，以测量由于该病而导致的脑细胞丧失。这种损失是许多痴呆症症状的原因，例如记忆问题，我们希望能够比以前可能更早检测这些变化。其次，我们将开发并验证新方法来衡量血液输送到大脑的变化，以及这如何影响氧递送。这些变化被认为是导致细胞死亡和组织损失涉及的重要过程之一，并且可能与血管痴呆症特别相关。我们还将花费大量时间检查我们开发的测量值既准确又是对未来痴呆症患者应用的实用性。我们将优化进行扫描过程的方式，以使患者躺在扫描仪中所需的时间最小化。这对于将来在临床环境中采用这些方法至关重要。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease.

DOI：
10.3389/fphys.2020.593026
发表时间：
2020
期刊：
Frontiers in physiology
影响因子：
4
作者：
Al-Bachari S;Naish JH;Parker GJM;Emsley HCA;Parkes LM
通讯作者：
Parkes LM

Dynamic Contrast Enhanced MRI reveals blood-brain barrier disruption in Parkinson's disease

动态对比增强 MRI 揭示帕金森病的血脑屏障破坏

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Al-Bachari S
通讯作者：
Al-Bachari S

Accuracy and robustness of image-derived input functions (IDIF) for preclinical PET imaging assessed using a dynamic 3D printed phantom

使用动态 3D 打印模型评估临床前 PET 成像的图像衍生输入函数 (IDIF) 的准确性和稳健性

DOI：
发表时间：
2017
期刊：
影响因子：
0
作者：
Asselin MC
通讯作者：
Asselin MC

Generation and validation of image-derived input functions from rodents using a dynamic 3D printed phantom

使用动态 3D 打印模型生成和验证啮齿动物的图像衍生输入函数

DOI：
发表时间：
2016
期刊：
影响因子：
0
作者：
Asselin MC
通讯作者：
Asselin MC

DOI：
10.1002/mrm.25197
发表时间：
2015-01
期刊：
MAGNETIC RESONANCE IN MEDICINE
影响因子：
3.3
作者：
Alsop, David C.;Detre, John A.;Golay, Xavier;Guenther, Matthias;Hendrikse, Jeroen;Hernandez-Garcia, Luis;Lu, Hanzhang;MacIntosh, Bradley J.;Parkes, Laura M.;Smits, Marion;van Osch, Matthias J. P.;Wang, Danny J. J.;Wong, Eric C.;Zaharchuk, Greg
通讯作者：
Zaharchuk, Greg