Core Capability for Chemistry Research at the University of Warwick

华威大学化学研究核心能力

• 批准号: EP/L027100/1
• 负责人: Mike Shipman
• 金额: $ 126.66万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FL027100%2F1
• 关键词: Core; Capability; Chemistry; Research; University; Core; Capability; Chemistry; Research; University

The main objective of this proposal is to enhance the research capabilities of the Department of Chemistry at the University of Warwick, through the acquisition of new equipment. We will add enhanced capabilities in matrix assisted laser desorption ionisation (MALDI) mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. These will have major beneficial impacts on >60% of staff and researchers in the Department through significant increases in both capacity (i.e. more samples can be run) and capability (i.e. better data through improved resolution). This equipment will enhance a wide range of research activities in EPSRC priority areas as detailed below:(i) Chemical Biology, where the proposed instruments will facilitate many programmes including genomics-driven natural product discovery and various medicinal chemistry programmes including the development of metal based pro-drugs. It will also underpin interests in Synthetic Biology. (ii) Synthesis and Catalysis - work in this EPSRC priority area includes work on transition metal catalysis, organocatalysis and biocatalysis. A variety of other synthetic chemistry programmes will be enhanced including those relevant to the EPSRC grand challenge, Dial-a-Molecule. (iii) Polymer Chemistry - many varied programmes will benefit including those focused on protein conjugation to polymers, glycopolymers, biomaterials, drug delivery and nanoreactors.(iv) Analytical Science - The increased sensitivity will enhance many projects including biophysical investigations of metalloproteins and membrane proteins. Importantly, the new capabilities will also help us further strengthen our engagement and collaboration with industry and relevant business sectors.

该提案的主要目的是通过收购新设备来增强沃里克大学化学系的研究能力。我们将在基质辅助激光解离（MALDI）质谱和核磁共振（NMR）光谱中添加增强的功能。这些将通过大幅提高容量（即可以运行更多样本）和能力（即通过改进的分辨率更好的数据）对部门的员工和研究人员产生重大的有益影响。该设备将增强EPSRC优先领域的广泛研究活动，如下所述：（i）化学生物学，拟议的仪器将促进许多计划，包括基因组驱动的自然产品发现和各种药物化学计划，包括基于金属基于金属的促剂量。它也将支持合成生物学的利益。 （ii）合成和催化 - 在此EPSRC优先区域中的工作包括过渡金属催化，有机催化和生物催化的工作。将增强各种其他合成化学计划，包括与EPSRC大挑战（Dial-A-Olecule）相关的合成化学计划。 （iii）聚合物化学 - 许多各种计划将受益，包括专注于蛋白质偶联的聚合物，糖聚合物，生物材料，药物输送和纳米反应器的蛋白质。（IV）分析科学 - 提高的敏感性将增强许多项目，包括许多项目，包括金属蛋白和膜蛋白和膜蛋白的生物物理研究。重要的是，新功能还将帮助我们进一步加强与行业和相关业务领域的参与和合作。