Terpene-based Manufacturing for Sustainable Chemical Feedstocks

可持续化学原料的萜烯制造

• 批准号: EP/K014889/1
• 负责人: Matthew Davidson
• 金额: $ 337.07万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK014889%2F1
• 关键词: Terpene; based; Manufacturing; Sustainable; Chemical

Our aim is to develop a sustainable, integrated platform for manufacture of industrial chemicals based on biological terpenoid feedstocks to complement carbohydrate, oil and lignin-based feedstocks that will be available to sustainable chemistry-using industries of the future. Our focus will include production of aromatics and amines which are particularly challenging targets from other biofeedstocks.Transition from fossil-based feedstocks to renewable alternatives is a key challenge for the 21st Century. Major efforts are underway to address this with work currently focused on carbohydrates, fats and oils, and lignins all of which give rise to fundamental technological barriers due to the incompatibility of complex and oxygen-rich materials with conversion technologies developed for simple hydrocarbon-based petrochemical feedstocks. This often requires biological feedstocks to undergo costly and inefficient transformations and separations prior to deployment in existing supply chains. In contrast, terpenes are an abundant class of natural products based on the C5 isoprene unit. As hydrocarbons they are easily separated from aqueous environments and can be readily upgraded using existing petrochemical technologies. While terpenes have been used in limited quantities since antiquity (notably as flavours and fragrances) they have yet to be exploited systematically for the production of platform chemicals even though they represent a potentially vast resource: global biogenic production of terpenes is 10^9 t/yr. Significant volumes of useful terpenes are already available on global markets at low cost (production of turpentine oils and limonene are 330,000 and 30,000 t/yr, respectively, the former costing 0.09-0.19 Euros per L). While this is sufficient in itself to justify a viable value-added chemical platform (metrics comparable to those for lignin: 1.1m t/yr at £250-2,000 per t) such figures will be dwarfed in the near future through the large-scale (multimillion t/yr) microbial production of terpenes such as farnesene for biofuels via the engineering of isoprene metabolic pathways. This industrial biotechnology (IB) approach, developed by Amyris and others, promises large-scale and geographically flexible supplies of terpenes via fermentation of plant sugars and cellulosic waste. Thus, the exploration of new generic technologies for the chemical exploitation of terpenes is timely, not only in terms of sustainable utilization of current global resources, but also to take advantage of major developments in IB. However, key challenges to be addressed in the context of terpene-based manufacturing include: (i) development and optimization of sustainable chemical transformations; (ii) scale-up of intensive conversion processes; (iii) development of new terpene sources; and (iv) systems-level understanding of technical, environmental and economic factors associated with new terpene-based manufacturing technologies. This project will address these challenges directly in four interconnected workpackages. Outputs from the project will provide a competitive advantage for one of the UK's most successful industries. Chemistry-reliant industries contributed an equivalent of 21% GDP to the UK economy in 2007, they support 6m jobs (RSC 2010), and turnover is growing at 5% pa (UKTI, 2009). The utilization of IB is vital to sustaining competitive advantage, with the value of the UK IB market in 2025 estimated at £4b to £12b (BERR 2009). Specific to this project, the development of new integrated technologies for terpene-based manufacturing, ultimately via microbial fermentation of waste cellulose, will provide competitive advantage for UK industries through new sustainable manufacturing processes, reduced feedstock costs, security of supply and reduced environmental impact. The UK will benefit further from export of new technologies and services and from development of new skills vital to future low carbon manufacturing.

我们的目标是开发一个可持续的综合平台，用于生产基于生物萜类原料的工业化学品，以补充碳水化合物、油和木质素原料，这些原料将可用于未来的可持续化学使用行业。芳香族化合物和胺类是其他生物原料特别具有挑战性的目标。从化石原料向可再生替代品的转变是 21 世纪的一个关键挑战，目前的工作重点是碳水化合物、由于复杂的富氧材料与为简单的基于碳氢化合物的石化原料开发的转化技术不相容，所有这些都会产生根本性的技术障碍，这通常需要对生物原料进行昂贵且低效的转化和转化。相比之下，萜烯是一类基于 C5 异戊二烯单元的丰富天然产物，作为碳氢化合物，它们很容易从水环境中分离出来，并且可以轻松使用进行升级。尽管萜烯自古以来的使用量有限（特别是作为香料和香料），但尚未被系统地用于平台化学品的生产，尽管它们代表着潜在的巨大资源：全球萜烯的生物产量为 10 ^9 吨/年。全球市场上已经可以低成本供应大量有用的萜烯（松节油和柠檬烯的产量为 330,000 吨）。和 30,000 吨/年，前者的成本为每升 0.09-0.19 欧元），但这本身就足以证明可行的增值化学平台的合理性（与木质素的指标相当：110 万吨/年，价格为 250- 英镑）。在不久的将来，通过大规模（数百万吨/年）微生物生产，这一数字将相形见绌。这种由 Amyris 等人开发的工业生物技术 (IB) 方法有望通过植物糖和纤维素废物的发酵来大规模和地域灵活地供应萜烯。探索新的萜烯化学开采通用技术是及时的，不仅是为了可持续利用当前全球资源，而且也是为了利用 IB 的重大发展。在萜烯制造方面涉及的问题包括：(i) 可持续化学转化的开发和优化；(ii) 强化转化工艺的规模化；(iii) 开发新的萜烯来源；以及 (iv) 系统层面的理解；该项目将通过四个相互关联的工作包直接解决这些挑战，该项目的成果将为英国最成功的行业之一提供竞争优势。 2007 年，化学相关行业为英国经济贡献了 21% 的 GDP，提供了 600 万个就业岗位（RSC 2010），营业额每年增长 5%（UKTI，2009）。 IB 的利用对于维持竞争力至关重要。优势，2025 年英国 IB 市场的价值估计为 40 亿至 120 亿英镑（BERR 2009）。最终通过废纤维素的微生物发酵开发基于萜烯的制造新集成技术，将通过新的可持续制造工艺、降低原料成本、供应安全和减少环境影响为英国工业提供竞争优势。新技术和服务的出口以及对未来低碳制造至关重要的新技能的开发。

项目成果

Esterification of geraniol as a strategy for increasing product titre and specificity in engineered Escherichia coli.

香叶醇的酯化作为提高工程大肠杆菌中产物滴度和特异性的策略。

• DOI: http://dx.10.1186/s12934-019-1130-0
• 发表时间: 2019
• 期刊: Microbial cell factories
• 影响因子: 6.4
• 作者: Chacón MG

Statistics of the network of organic chemistry

有机化学网统计

• DOI: 10.1039/c7re00129k
• 发表时间: 2018-02-06
• 期刊: Reaction Chemistry and Engineering
• 影响因子: 3.9
• 作者: Philipp;A. Lapkin
• 通讯作者: A. Lapkin

Exploring configuration transitions in nascent and emergent supply networks

探索新生和新兴供应网络的配置转变

• 期刊: International Journal of Production Economics
• 影响因子: 12
• 作者: Harrington TS

Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multichannel reactor

结构化多通道反应器中 1,4-环己二酮的连续流动液相脱氢

• DOI: 10.1039/c8re00176f
• 发表时间: 2024-09-13
• 期刊: Reaction Chemistry & Engineering
• 影响因子: 3.9
• 作者: M. Ashraf;J. Tan;M. Davidson;S. Bull;Marc Hutchby;D. Mattia;P. Plucinski
• 通讯作者: P. Plucinski

MOESM1 of Esterification of geraniol as a strategy for increasing product titre and specificity in engineered Escherichia coli

香叶醇酯化的 MOESM1 作为提高工程大肠杆菌中产物滴度和特异性的策略

• DOI: http://dx.10.6084/m9.figshare.8246558
• 发表时间: 2019
• 作者: Chac??n M