High-speed multi-channel 3-D Optical Coherence Tomography studies of the biomechanics of skin friction.

皮肤摩擦生物力学的高速多通道 3D 光学相干断层扫描研究。

基本信息

批准号：
EP/K009699/1
负责人：
Stephen Matcher
金额：
$ 83.18万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FK009699%2F1
关键词：
speed multi channel Optical Coherence

项目摘要

The health of the skin has profound effects on both our physical and psychological well-being. Enormous academic and commercial effort is devoted to optimising the health and appearance of skin. The barrier function of skin has been widely studied, but less well studied is its role in providing enough friction to allow us to grip and manipulate objects. Excessive friction can produce undesirable skin conditions such as chaffing and irritation in many scenarios such as wearing a respiration face mask or the skin being in contact with a damp surface. Conversely reduction of skin friction can occur in old age and compound the difficulties experienced by the older population when gripping and manipulating objects.Many potential determinants of friction have been studied, including applied load, skin deformation, skin mechanical properties and surface textures and materials, but the sub-surface behaviour and skin strain has not been investigated as rigorously. Most of these parameters have been investigated statically and although it is known that they will change when the contact is dynamic no quantitative data is available for using in computer models of skin.The aim in this work will be to develop new imaging techniques to allow sub-surface observation of how skin behaves when it is sliding against an object and what influences this the most, for example, skin moisture, applied load, sliding speed etc. The contact area between skin and object will also studied in greater detail than before as this has a major effect on friction and as yet no techniques exist for characterising this in a moving contact.The objectives of the work will initially focus on developing the equipment and techniques needed to observe the surface and sub-surface behaviour. These will then be combined with skin testing apparatus to allow the measurements of friction etc. to be taken in parallel with the sub-surface images.The information from the tests and the techniques themselves will then be applied in three practical case studies to ensure real world impact for the work. The first will involve working with Philips on studying facial masks used by sleep apnea sufferers. Test data will help improve computer models of the contact between facial skin and a mask. The second will be carried out with Unilever and focus on characterising the effects of skin creams and cleansers. The final case study will be on using the new non-invasive imaging technique in clinical studies carried out by dermatologists at The University of Sheffield to replace tape-stripping methods currently used to study skin damage.

皮肤的健康对我们的身体和心理健康都有深远的影响。巨大的学术和商业努力致力于优化皮肤的健康和外观。皮肤的障碍功能已被广泛研究，但研究较少的是它在提供足够的摩擦以使我们能够握住和操纵物体方面的作用。在许多情况下，过度的摩擦会产生不良的皮肤状况，例如戴呼吸面罩或与潮湿表面接触的皮肤等许多情况。相反，在抓握和操纵物体时，已经研究了摩擦的摩擦决定因素，包括施加的负载，皮肤变形，皮肤机械性能以及表面纹理和材料，但尚未严格调查摩擦量和皮肤劳伤。这些参数中的大多数已经进行了静态调查，尽管众所周知，当接触是动态的情况下它们会发生变化，无定量数据可用于在皮肤的计算机模型中使用。这项工作的目的是开发新的成像技术，以使皮肤在对象上的效果以及在对物体上的影响以及较大的对象，例如，在皮肤上的速度和对物体的速度相比，允许皮肤的表现如何。这对摩擦有重大影响，但目的是在移动接触中表征这一点。作品的目标最初将集中于开发观察表面和地下行为所需的设备和技术。然后，这些将与皮肤测试设备结合使用，以允许与地下图像并行进行摩擦等的测量。测试和技术本身的信息将在三个实用案例研究中应用，以确保现实世界对工作的影响。第一个将涉及与飞利浦研究睡眠呼吸暂停患者使用的面罩。测试数据将有助于改善面部皮肤和口罩之间接触的计算机模型。第二个将与联合利华进行，并专注于表征皮肤霜和清洁剂的影响。最终的案例研究将在谢菲尔德大学的皮肤科医生进行的临床研究中使用新的非侵入性成像技术，以替换目前用于研究皮肤损伤的胶带剥离方法。