High-speed multi-channel 3-D Optical Coherence Tomography studies of the biomechanics of skin friction.

皮肤摩擦生物力学的高速多通道 3D 光学相干断层扫描研究。

基本信息

批准号：
EP/K009699/1
负责人：
Stephen Matcher
金额：
$ 83.18万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FK009699%2F1
关键词：
speed multi channel Optical Coherence

项目摘要

The health of the skin has profound effects on both our physical and psychological well-being. Enormous academic and commercial effort is devoted to optimising the health and appearance of skin. The barrier function of skin has been widely studied, but less well studied is its role in providing enough friction to allow us to grip and manipulate objects. Excessive friction can produce undesirable skin conditions such as chaffing and irritation in many scenarios such as wearing a respiration face mask or the skin being in contact with a damp surface. Conversely reduction of skin friction can occur in old age and compound the difficulties experienced by the older population when gripping and manipulating objects.Many potential determinants of friction have been studied, including applied load, skin deformation, skin mechanical properties and surface textures and materials, but the sub-surface behaviour and skin strain has not been investigated as rigorously. Most of these parameters have been investigated statically and although it is known that they will change when the contact is dynamic no quantitative data is available for using in computer models of skin.The aim in this work will be to develop new imaging techniques to allow sub-surface observation of how skin behaves when it is sliding against an object and what influences this the most, for example, skin moisture, applied load, sliding speed etc. The contact area between skin and object will also studied in greater detail than before as this has a major effect on friction and as yet no techniques exist for characterising this in a moving contact.The objectives of the work will initially focus on developing the equipment and techniques needed to observe the surface and sub-surface behaviour. These will then be combined with skin testing apparatus to allow the measurements of friction etc. to be taken in parallel with the sub-surface images.The information from the tests and the techniques themselves will then be applied in three practical case studies to ensure real world impact for the work. The first will involve working with Philips on studying facial masks used by sleep apnea sufferers. Test data will help improve computer models of the contact between facial skin and a mask. The second will be carried out with Unilever and focus on characterising the effects of skin creams and cleansers. The final case study will be on using the new non-invasive imaging technique in clinical studies carried out by dermatologists at The University of Sheffield to replace tape-stripping methods currently used to study skin damage.

皮肤的健康对我们的身心健康有着深远的影响。巨大的学术和商业努力致力于优化皮肤的健康和外观。皮肤的屏障功能已被广泛研究，但对其提供足够摩擦力以让我们抓握和操纵物体的作用的研究较少。在许多情况下，例如佩戴呼吸面罩或皮肤与潮湿表面接触，过度摩擦会产生不良的皮肤状况，例如擦伤和刺激。相反，老年时皮肤摩擦力会减少，这会加剧老年人抓握和操纵物体时遇到的困难。人们已经研究了许多摩擦力的潜在决定因素，包括施加的载荷、皮肤变形、皮肤机械性能以及表面纹理和材料，但地下行为和皮肤应变尚未得到严格研究。大多数这些参数都是静态研究的，尽管众所周知，当接触动态时它们会发生变化，但没有定量数据可用于皮肤的计算机模型。这项工作的目的是开发新的成像技术，以允许亚- 表面观察皮肤在物体上滑动时的行为以及对其影响最大的因素，例如皮肤湿度、施加的负载、滑动速度等。皮肤和物体之间的接触面积也将比以前更详细地研究这对摩擦力有重大影响，但目前还没有技术可以解决这一问题在移动接触中表征这一点。这项工作的目标最初将集中于开发观察表面和地下行为所需的设备和技术。然后，这些将与皮肤测试设备相结合，以便与地下图像并行地进行摩擦力等的测量。然后，来自测试的信息和技术本身将应用于三个实际案例研究，以确保真实的对工作的世界影响。第一个项目将与飞利浦合作研究睡眠呼吸暂停患者使用的面膜。测试数据将有助于改进面部皮肤和口罩之间接触的计算机模型。第二个项目将与联合利华合作进行，重点是表征护肤霜和清洁剂的效果。最后的案例研究将是在谢菲尔德大学皮肤科医生进行的临床研究中使用新的非侵入性成像技术来取代目前用于研究皮肤损伤的胶带剥离方法。