TECHNIQUES FOR DETECTION OF LESIONS IN CORONARY ARTERIES

冠状动脉病变检测技术

• 批准号: 3356170
• 负责人: HOWARD L KANTOR
• 金额: $ 35.36万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3356170
• 关键词: angiography; antihyperlipoproteinemic agent; artery stenosis; atherosclerosis; blood flow measurement; cardiography; cardiovascular disorder diagnosis; contrast media; coronary artery; coronary occlusion /thrombosis; densitometry; diagnosis design /evaluation; diagnostic catheterization; dipyridamole; disease /disorder proneness /risk; heart circulation; heart transplantation; histopathology; human subject; human tissue; image enhancement; image processing; interferometry; lipids; longitudinal human study; magnetic resonance imaging; miniature swine; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; phantom model; polyvinyls; radionuclide diagnosis; vascular resistance; vasomotion

This grant proposal addresses the non-invasive evaluation of coronary stenoses using Nuclear Magnetic Resonance imaging techniques. We will evaluate and improve several imaging methods to both directly measure and discern the effects of coronary stenoses. These methods include: standard spin-echo NMR imaging and viewing angle correction to image large portions of the coronary anatomy; flow velocity multi-dimensional imaging limited slice-selective 3D NMR angiography; slice- selective 2D projected NMR angiography; time-of-flight NMR imaging. Besides examination of the coronary vessel to determine the patent lumen, we will also be detecting and quantitating the atheroma in the coronary wall. We will evaluate these techniques in the following systems: a) a phantom 2-5 mm polyvinyl chloride tubing model of coronary stenosis with pulsatile flow and associated with a model of respiratory related motion, b) a porcine model of coronary atherogenesis allowing the longitudinal examination of coronary anatomy by cardiac catheterization and NMR non-invasive techniques as well as the single time point comparison of these methods with pathologic corroboration, c) the examination of human subjects who have undergone x-ray coronary angiography to compare results with this standard clinical x-ray modality, as well as the examination of human subjects who are scheduled to undergo cardiac transplantation for direct comparison of NMR determined coronary stenoses with pathologic specimens. We address the major limitations of NMR imaging for the observation of coronary anatomy which include limitations of resolution and signal-to-noise. We will be implementing variations of standard NMR sequences to reduce these limitations and will utilize methods of post-processing resolution enhancement to bring out the detail of coronary atheromata. As part of our atheroma detection protocol, we will use NMR microscopic techniques to improve the specifically and sensitivity of our measurements. We will also examine the utility of NMR as a measure of the flow limiting character of coronary stenoses by performing measurements before and after the administration of dipyridamole to our porcine model. Changes in flow in this system will be monitored with the radioactive microsphere blood flow method.

该拨款提案涉及非侵入性评估 使用核磁共振成像检查冠状动脉狭窄 技术。 我们将评估和改进多项成像 直接测量和辨别影响的方法 冠状动脉狭窄。 这些方法包括： 标准自旋回波 核磁共振成像和视角校正以获取大图像 冠状动脉解剖结构的一部分；多维流速 成像有限切片选择性 3D NMR 血管造影；片- 选择性二维投影核磁共振血管造影；飞行时间核磁共振 成像。 除了检查冠状血管以确定 专利流明，我们还将检测和定量 冠状动脉壁粥样硬化。 我们将评估这些技术 在以下系统中： a) 2-5 mm 聚氯乙烯模型 脉动血流冠状动脉狭窄管道模型 与呼吸相关运动模型相关，b) a 猪冠状动脉粥样硬化模型允许纵向 通过心导管插入术检查冠状动脉解剖结构 NMR 非侵入性技术以及单一时间点 这些方法与病理证实的比较，c) 对接受过 X 射线检查的人体进行检查 冠状动脉造影以将结果与该标准进行比较 临床 X 射线模式以及人体检查 计划接受心脏移植的受试者 NMR 确定的冠状动脉狭窄与 病理标本。 我们解决了 NMR 成像的主要局限性 冠状动脉解剖的观察，包括限制 分辨率和信噪比。 我们将实施 标准 NMR 序列的变化可减少这些限制 并将利用后处理分辨率的方法 增强以显示冠状动脉粥样硬化的细节。 作为我们动脉粥样硬化检测方案的一部分，我们将使用 NMR 显微技术提高特异性和灵敏度 我们的测量。 我们还将研究 NMR 的实用性： 冠状动脉狭窄的血流限制特征的测量 在给药之前和之后进行测量 双嘧达莫到我们的猪模型中。 本次流量变化 系统将用放射性微球血液进行监测 流动法。