The development of a low cost, fibre coupled terahertz spectrometer

低成本光纤耦合太赫兹光谱仪的开发

基本信息

批准号：
EP/H029583/1
负责人：
Edmund Harold Linfield
金额：
$ 18.9万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH029583%2F1
关键词：
development low cost fibre coupled

项目摘要

In this proposal, we seek Follow-on funding to support the technical and commercial development of a cheap highly portable terahertz (THz) frequency time-domain spectrometer that will, within a five year timescale, reduce both the cost and size of such instrumentation by a factor of >10. The IP which we will exploit is the generation and detection of terahertz radiation from a new material (iron-doped indium gallium arsenide, Fe-InGaAs) which is showing tremendous potential for integration with relatively cheap telecoms wavelength lasers, which we developed using a recent EPSRC grant (PORTRAIT; EP/D50225X/1). We have protected use of this material for THz spectroscopy by a recent GB patent application (GB 0912512.1), and now seek to commercialize our results in order to push the wide-scale uptake of THz spectroscopy systems across a broad range of application areas, which include (but are not restricted to) the pharmaceutical, security, process monitoring, and medical sectors. In each area, there have been extensive demonstrations (by both academia and industrial R&D laboratories) of the potential impact of THz spectroscopy, but the keys factors of price and lack of portability have so far limited commercial uptake. Our new material allows efficient THz emission using cheap and highly portable (1.55 micron) fibre lasers. We have shown that it is possible to construct fibre-coupled THz emitters and detectors using our material which offer greater flexibility and enhanced performance compared to existing technology. We now seek to create optimized prototype THz emitters and detector components, based on our recently patented new material, which will be appropriate for widespread applications of THz frequency range sensing across many sectors.Terahertz time-domain spectroscopy (THz-TDS) systems have wide-scale applicability, especially for the measurement of polycrystalline powders, which typically have characteristic fingerprint spectra in the THz frequency range. THz spectroscopy and imaging systems thus offer the possibility of non-contact characterization and monitoring of a wide range of materials, which include pharmaceutical drugs, drugs-of-abuse, and explosives, inter alia. We are targeting the pharmaceutical market during the Follow-on funding period, owing to the established use of THz technology there. THz-TDS is proven to have importance in the pharmaceutical industry owing to its ability to distinguish polymorphic forms, and the ability to penetrate tablet coatings and packaging. Furthermore, it provides complementary information to other vibrational spectroscopic techniques, particularly Raman spectroscopy, owing to the different selection rules governing which normal modes are observed. The US Food and Drug Administration guidance for pharmaceutical development, manufacturing, and quality assurance has explicitly placed process analytical technologies, such as THz-TDS, as central to innovation in pharmaceutical manufacture over the coming decade.

在此提案中，我们寻求跟进资金，以支持便宜的高度便携式Terahertz（THZ）频率时域光谱仪的技术和商业开发一个> 10的因素。我们将利用的IP是从一种新材料（铁掺杂的砷酰胺，Fe-Ingaas）生成和检测到Terahertz辐射的生成和检测，该材料显示出与相对便宜的电信激光器整合的巨大潜力EPSRC Grant（肖像； EP/D50225X/1）。我们通过最近的GB专利应用（GB 0912512.1）保护了该材料用于THZ光谱的使用，现在试图将我们的结果商业化，以便推动广泛的应用领域的THZ光谱系统的广泛吸收，这些应用程序范围广泛的应用领域包括（但不限于）药物，安全性，过程监控和医疗部门。在每个领域，都有广泛的示威（由学术界和工业研发实验室）就THZ光谱的潜在影响进行了广泛的示威，但是到目前为止，价格的关键因素和缺乏可移植性的关键因素已经有限。我们的新材料允许使用廉价且高度便携式（1.55微米）的光纤激光器有效地发射。我们已经证明，与现有技术相比，我们可以使用我们的材料来构建纤维耦合的THZ发射器和检测器。现在，我们试图根据我们最近获得专利的新材料来创建优化的原型THZ发射器和检测器组件，这将适用于许多扇区的THZ频率范围传感的广泛应用。 - 规模适用性，尤其是用于测量多晶粉，通常在THZ频率范围内具有特征性的指纹光谱。因此，THZ光谱和成像系统提供了非接触式表征和监测多种材料的可能性，其中包括药物，滥用药和炸药，除其他外。由于在那里既定使用THZ技术，因此我们在随后的资金时期目标是针对制药市场。由于其区分多态性形式的能力以及穿透片剂涂料和包装的能力，因此THZ-TD在制药行业中具有重要意义。此外，它提供了与其他振动光谱技术（尤其是拉曼光谱）的互补信息，这是由于观察到正常模式的不同选择规则。美国食品药品监督管理局的药物开发，制造和质量保证指南已明确置于工艺分析技术（例如THZ-TDS），这是在未来十年中制药制造创新的核心。