NOVEL METHOD FOR OPTICAL COHERENCE TOMOGRAPHY AND MULTIPLEXED SENSING

光学相干断层扫描和多重传感的新方法

基本信息

批准号：
EP/H004963/1
负责人：
Adrian Podoleanu
金额：
$ 50.22万
依托单位：
University of Kent
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH004963%2F1
关键词：
NOVEL METHOD OPTICAL COHERENCE TOMOGRAPHY

项目摘要

Optical coherence tomography (OCT) allows high depth resolution imaging and has received considerable interest in the last 5 years, which resulted in a 100 times increase in the speed of operation and extension to a large variety of imaging problems. There are two main types of OCT: time domain (TD) and spectral domain (SD). The recent progress in speed has been achieved by developers working in the SD-OCT field. However, SD-OCT has several disadvantages, non present in TD-OCT. The research in SD-OCT has also stimulated the development of novel fast tunable lasers, the so called swept sources (SS). Tremendous effort has been put in understanding and controlling the phenomena in closed optical loops containing optical amplifiers for optical sources to be used in SS-OCT. The present proposal puts forward a novel type of OCT and a novel class of optical interferometers. This is driven by the needs to address the limitations in terms of speed of the TD-OCT method, by the potential of the en-face OCT, not investigated so far, in producing 3D OCT exploration and by the limitations in terms of range and dynamic focus of the SD-OCT methods as well as dispersion compensation of all OCT methods. The novel method and devices proposed are inspired by the progress in swept sources and SS-OCT. A new class of OCT systems is researched, as a marriage between the TD-OCT and SD-OCT methods. The new OCT method eliminates or ameliorate the disadvantages of the SD-OCT method. The novel method presents the generality of being compatible with both TD-OCT and SD-OCT. The applicant has demonstrated the principle of operation which guarantees the success of research. However, the marriage between the SD-OCT and TD-OCT to be researched here promises much more than what the demonstrator set-up has shown so far, therefore research support is sought to explore the multiple avenues of the novel method. This may revolutionise the field of OCT and open applications not currently possible with the present OCT technology, such as SD-OCT of objects extended in depth by more than 1 cm (eye), or en-face imaging of moving organs or tissue (of the whole retina volume in fractions of a second, with better sampling in all directions than achievable with the most advanced SD-OCT set-up). The method to be researched will allow combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. Novel directions are opened in the instantaneous elimination of the movement effects of the tissue when determining the liquid (blood) flow profile in a vessel, in tracking the axial position of objects (cornea or retina), automatic dispersion compensation as well as improvement in the synchronism between the coherence gate and the focus in axial scanning (a problem for both types of SD-OCT methods). The method proposed is also applicable in multiplexing of sensors. Simultaneous measurements over multiple path lengths become feasible. Three proof of concept demonstrators will be assembled, for multiple imaging at different depths using en-face TD-OCT, fast and long range tracking and swept source systems for long axial scanning.

光学相干断层扫描（OCT）允许高深度分辨率成像，并在过去5年中引起了极大的兴趣，这导致运行速度和扩展到各种成像问题的速度增加了100倍。 OCT有两种主要类型：时域（TD）和光谱域（SD）。在SD-OCT领域工作的开发人员已经取得了速度的最新进展。但是，SD-OCT在TD-OCT中存在几个缺点。 SD-OCT的研究还刺激了新型快速可调激光器的发展，即所谓的扫描源（SS）。在理解和控制包含光学放大器的封闭光学环中的现象方面已付出了巨大的努力，用于用于SS-OCT中的光源。本提案提出了一种新型的OCT和新型的光学干涉仪类型。这是由于需要解决TD-OCT方法速度的局限性所驱动的，这是由迄今为止迄今为止尚未调查的ECT的潜力在产生3D OCT探索方面以及SD-OCT方法的范围和动态重点的局限性以及所有OCT方法的范围和动态重点的局限性。提出的新方法和设备的灵感来自扫描源和SS-OCT的进展。研究了新的OCT系统，作为TD-OCT和SD-OCT方法之间的婚姻。新的OCT方法消除或改善了SD-OCT方法的缺点。这种新方法表明了与TD-OCT和SD-OCT兼容的通用性。申请人证明了运营原则，该原则保证了研究的成功。但是，在此要研究的SD-OCT和TD-OCT之间的婚姻比迄今为止示威者设置所显示的要多得多，因此寻求研究支持来探索新方法的多种途径。这可能会彻底改变目前OCT技术目前无法使用的OCT和开放应用程序的领域，例如，对物体的SD-OCT深度延伸超过1 cm（眼睛），或者对移动器官或组织的成像进行成像（在第二个视网膜或组织中，第二个视网膜量的部分，在所有方向上都可以在所有方向上进行更好的采样，而不是与最先进的SD-OST设置相比）。要研究的方法将允许将扫描机制和操作模式组合起来，以在移动组织的3D成像（例如眼睛，心脏或移动的胚胎或功能/低噪声成像）中实现多功能功能，通过使用角色化合物或极化。在确定容器中的液体（血液）流动剖面，跟踪物体（角膜或视网膜）的轴向位置，自动分散补偿以及改善相干门和轴向扫描中的焦点之间的同步（一种问题）方面，在瞬时消除组织的运动效应时，打开了新的方向。提出的方法也适用于传感器的多路复用。在多个路径长度上的同时测量变得可行。将组装三个概念示威者证明，用于使用face TD-OCT在不同深度进行多次成像，快速和长距离跟踪以及用于长轴向扫描的源系统。