Uncovering the mechanisms through which krill oil increases muscle function in older adults

揭示磷虾油增强老年人肌肉功能的机制

• 批准号: BB/X015998/1
• 负责人: Stuart Gray
• 金额: $ 62.29万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FX015998%2F1
• 关键词: Uncovering; mechanisms; through; krill; oil

As we age, unfortunately, we lose muscle strength and this frequently results in older people not being able to carry out everyday tasks, such as getting up from a chair or stepping on to a bus. This results in a reduced quality of life and an increased risk of having a fall that can result in hospitalisation. Low muscle strength is also a risk factor for many conditions such as diabetes, cancer and cardiovascular disease and makes recovery from any illness slower. These negative consequences translate to large economic costs with the most recent study in 2016 showing that the excess health and social care cost of muscle weakness in the UK was £2.5 billion/year. Currently we do not have any medicines that are effective in reversing muscle weakness and although resistance (weightlifting) exercise works, very few people do this, and any gains are readily lost after stopping training. Excitingly, in a study of around 100 people, we have recently shown that krill (small crustaceans) oil supplementation for 6 months results in a 10% increase in muscle strength, equivalent to the loss of muscle strength seen from 55 to 65 years of age. Whilst this is exciting, we need to understand the mechanisms underlying these effects to optimise treatment. Our data indicates that the increases in strength may be due to more effective transmission of the signal from the brain to the muscle, via the nerves, but exactly where is not clear. Furthermore, we need to investigate whether the increases in muscle strength and mass result in improvements in how older people perform daily activities like walking and getting up from a chair. The aim of the current study, therefore, is to determine the mechanisms via which krill oil supplementation increases muscle strength, and to determine whether it results in improvements in daily activities. In the proposed study we will recruit 80 older adults and supplement them for 6 months with placebo or krill oil and compare the effects of this on muscle size and strength, the brain-nerve-muscle interactions and its effects on daily activities. Together, this series of experiments will provide a comprehensive understanding of the effects of krill oil supplementation on muscle function, performance of daily activities and provide an in-depth characterisation of the mechanisms underlying these effects. Such information is crucial to optimise strategies to prevent and/or treat the age-related decline in muscle function.

不幸的是，随着年龄的增长，我们会失去肌肉，而经常导致老年人从椅子上脱颖而出或踏上公共汽车的日常任务。许多疾病的危险因素，例如糖尿病，癌症性血管疾病，使这些负面后果恢复到较慢的经济成本。肌肉无力和阻力（举重）运动作品，很少有人这样做，并且在停止后，在对大约100人的研究中，我们最近有Crustaceans soil corseption soil补充了6个月，导致了10％的增长在肌肉强度上，相当于从55个年龄的刺激性的肌肉力量的丧失，而这种令人兴奋的FFECT可以优化我们的数据。 LE力量和质量会改善较旧的日常活动，例如从椅子上行走和起床。在日常活动中，我们将招募80名老年人，并用安慰剂或磷虾油培养6个月，并比较肌肉大小和条纹的影响，这是脑穆斯科国际TS的日常活动经验将对磷虾油的影响对肌肉功能的影响进行全面的理解，对于优化公主和/或治疗与年龄相关的肌肉功能下降的策略至关重要。