Muscle resilience across the life course: from cells to society

整个生命过程中的肌肉弹性：从细胞到社会

• 批准号: BB/W018284/1
• 负责人: Peter Smith
• 金额: $ 37.41万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW018284%2F1
• 关键词: Muscle; resilience; across; life; course; Muscle; resilience; across; life; course

The number of people living into old age is increasing rapidly throughout the world, however although people live longer, they are not healthier. Adults in the UK now spend the last decade of life in poor health, placing a large burden on health and social care services. One of the big changes in our bodies as we age is the loss of muscle tissue, with up to 50% of muscle mass being lost by 80 years of age. Muscle is an important tissue in our body, as it is vital for movement, posture and the way in which food is used as energy. The loss of muscle during ageing makes it harder to carry out day-to-day activities, increases frailty and the risk of falls and injuries, and increases the risk of conditions like heart disease, diabetes and dementia. Muscle loss is the single largest reason for losing independence in old age, so it is important to keep our muscles healthy (resilient) as we grow older, by eating well and leading an active lifestyle.When muscles age, several things happen: muscle fibres become smaller and fewer in number, the muscle contains more fat and fibrous tissue, and the ability of muscle tissue to repair and renew itself decreases. Not everyone ages in the same way - in fact there is a great deal of variation when we look at large numbers of older people. Some of the differences between people can be explained by the genes an individual inherits. Much of the remaining variation is due to a person's life circumstances. Factors like how much exercise we take, the food we eat, our educational background and whether we live comfortably or in poverty all play a major role. Although scientists around the world have worked hard to understand the causes of muscle ageing, it is such a complex problem that we need to find new ways to tackle it. In the past, researchers have tended to focus on one part of the problem, in an area where they are expert. We plan to take a new approach that shifts away from studying single systems on their own and move towards a combined effort where we study muscle ageing across all scales from the microscopic level to the scale of populations. We will also join forces with researchers from other disciplines like mathematics, artificial intelligence, social sciences and geography to find new approaches to solving the big questions in muscle ageing. The aim of this network is to bring together researchers, businesses and the people and organisations that benefit from research, from many areas, offering new insights into muscle health and an understanding of the pathways leading to muscle ageing. Specifically we will:Develop a national network of researchers across a wide range of disciplines to focused on muscle resilience and ageing throughout life and across scales.Increase the understanding of the mechanisms influencing muscle ageing and the variability between individuals. Provide secondments and training for early career scientists and technical staff.Work with policy makers, health care practitioners, industry and patient groups to translate our insights into improved health benefits, developing new preventative and treatment strategiesThe outcomes of our network activities will be wide ranging, spanning from new scientific insights, the application of new technologies, interdisciplinary grant proposals, to training and exchange of knowledge across disciplines, to helping make policy at the national level, with the unified aim of relieving the major societal problems connected to muscle ageing and loss of mobility.

在全世界，居住在老年的人数正在迅速增加，但是尽管人们寿命更长，但他们的健康状况并不健康。现在，英国的成年人在健康状况不佳中度过了最后十年，给健康和社会护理服务带来了巨大负担。随着年龄的增长，我们身体的重大变化之一是肌肉组织的丧失，高达50％的肌肉质量在80岁时损失。肌肉是我们体内重要的组织，因为它对于运动，姿势和用作能量的方式至关重要。衰老期间肌肉的丧失使得每天的活动更难增加，增加脆弱和跌倒和伤害的风险，并增加患心脏病，糖尿病和痴呆症等疾病的风险。肌肉损失是老年失去独立性的唯一最大原因，因此随着年龄的增长，饮食良好并过着积极的生活方式，保持肌肉健康（弹性）很重要。当肌肉衰老时，会发生几件事：肌肉纤维的数量越来越小，肌肉的数量越来越小，肌肉的数量较小，肌肉包含更多脂肪和纤维化的组织，降低了肌肉组织和肌肉组织和肌肉组织的能力。并非每个人都以相同的方式年龄 - 实际上，当我们看大量老年人时，会有很大的变化。人们之间的某些差异可以用个人继承的基因来解释。其余的大部分差异是由于一个人的生活环境所致。诸如我们接受多少运动，我们吃的食物，我们的教育背景以及我们的生活舒适还是贫穷之类的因素都起着重要作用。尽管世界各地的科学家一直在努力理解肌肉衰老的原因，但这是一个复杂的问题，我们需要寻找新的方法来解决它。过去，研究人员倾向于将问题的一部分集中在他们是专家的领域。我们计划采用一种新的方法，该方法从自己研究单个系统中转移到了共同的努力中，我们将研究从微观水平到种群规模的所有尺度上研究肌肉衰老。我们还将与来自数学，人工智能，社会科学和地理的其他学科的研究人员联合起来，以找到解决肌肉衰老中的大问题的新方法。该网络的目的是将研究人员，企业以及从许多领域中受益的人和组织聚集在一起，为肌肉健康提供新的见解，并了解导致肌肉衰老的途径。具体而言，我们将：在各种各样的学科中发展一个国家的研究人员网络，以关注整个生命和跨鳞片的肌肉韧性和衰老。了解影响肌肉衰老的机制和个体之间的变异性。为早期的职业科学家和技术人员提供订婚和培训。与政策制定者，卫生保健从业人员，行业和患者群体一起工作，将我们的见解转化为改善的健康益处，开发新的预防和治疗策略，我们的网络活动的结果将广泛范围，范围广泛，跨越了新的科学见解，以跨越新技术，跨学科的培训，跨学科，跨学科的培训，跨学科的培训，跨学科，跨学科的交流，跨学科，跨学科的培训，跨学科，跨学科的培训，跨学科的培训，跨学科，跨学科的培训。统一的目标是减轻与肌肉衰老和流动性丧失有关的主要社会问题。