Understanding T cell trafficking and function during antigenic interference

了解抗原干扰期间 T 细胞的运输和功能

• 批准号: DP240101665
• 负责人: Prof Katherine Kedzierska
• 金额: $ 54.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101665
• 关键词: Understanding; cell; trafficking; function; during

Science generally studies antigenic stimulation in isolation, by measuring immunity towards antigens derived from a single pathogen. However, as mammals can harbour more than one infection at any given time, we established a model of antigenic interference using different antigens derived from two unrelated pathogens, influenza A (IAV) and Semliki Forest virus (SFV). Our data show that prior exposure to either IAV or SFV greatly perturbs T cell dynamics. This proposal will study, at cellular and molecular levels, T cell trafficking, function and clonal distribution during antigenic interference, thus advance fundamental knowledge on T cell immunity during antigenic competition, and provide a new paradigm on how we research T cell immunity.

科学通常通过测量对源自单一病原体的抗原的免疫力来单独研究抗原刺激。然而，由于哺乳动物在任何给定时间都可能携带不止一种感染，因此我们使用源自两种不相关病原体甲型流感 (IAV) 和塞姆利基森林病毒 (SFV) 的不同抗原建立了抗原干扰模型。我们的数据表明，先前接触 IAV 或 SFV 会极大地扰乱 T 细胞动力学。该提案将从细胞和分子水平研究抗原干扰过程中T细胞的运输、功能和克隆分布，从而推进抗原竞争过程中T细胞免疫的基础知识，为研究T细胞免疫提供新的范式。