MEASURE OF HUMAN RECEPTOR AND POST-RECEPTOR ACTIVITY

人类受体和受体后活性的测量

• 批准号: 3266444
• 负责人: DONALD C. HOOD
• 金额: $ 15.13万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3266444
• 关键词: cone cell; electroretinography; human subject; light adaptations; light intensity; mathematical model; model design /development; retina disorder; rod cell; visual photoreceptor

DESCRIPTION: (Investigator's abstract): The electroretinogram, ERG, is currently a valuable noninvasive technique available for diagnosing and following the course of retinal diseases. It has recently been shown that the initial portion of the human ERG can provide a quantitative measure of human rod receptor activity (Hood & Birch, 1990). These findings suggest that the ERG can be employed to answer fundamental questions about the functioning of both normal and abnormal human rod photoreceptors. Understanding rod receptor involvement in different diseases and in the normal process of light adaptation are among the specific aims of the proposed research. Our successful application of a quantitative model of the rod from the animal physiological literature encourages us to extent this work along two lines. First, we propose to measure cone a-waves and to compare them to models of cone receptor activity. In addition, alternative models of human cone receptor adaptation will be tested. Second, the long term goal of the proposed research is a quantitative model of the human ERG useful for testing hypotheses about normal and abnormal retinal activity. Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors.

描述：（研究者摘要）：视网膜电图，ERG，是 目前是一种有价值的非侵入性技术，可用于诊断和 遵循视网膜疾病的病程。 最近有研究表明 人类 ERG 的初始部分可以提供定量测量 人类视杆细胞受体活性（Hood & Birch，1990）。 这些发现表明 ERG 可用于回答有关 正常和异常的人类视杆细胞感光器的功能。 了解视杆细胞受体参与不同的疾病和 光适应的正常过程是其具体目标之一 提出的研究。 我们成功应用了定量模型 动物生理学文献中的棒鼓励我们延伸 这项工作有两条线。 首先，我们建议测量锥 a 波和 将它们与视锥受体活性模型进行比较。 此外， 将测试人类视锥细胞受体适应的替代模型。 其次，拟议研究的长期目标是定量模型 人类 ERG 可用于检验正常和异常的假设 视网膜活动。 因此，我们建议开发人类 ERG 模型 包括内核层的活动以及 受体。