AUTOMATED GAS ENHANCED VASCULAR IMAGING

自动气体增强血管成像

基本信息

批准号：
2896807
负责人：
ELVIRA Valentina LANG-ANDERSON
金额：
$ 13.05万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-30 至 2001-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2896807
关键词：
biomedical automation cardiovascular disorder diagnosis cardiovascular imaging /visualization computed axial tomography contrast media diagnosis design /evaluation magnetic resonance imaging method development pulmonary circulation obstruction radionuclides respiratory disorder diagnosis respiratory imaging /visualization swine xenon

项目摘要

Intravascular injection of contrast solutions is the de facto standard method for diagnosis of vasoocclusive disease. These agents have osmolar, chemotoxic, and anaphylactic risks. Substitution of gas as contrast medium has significant potential to avoid these recognized limitations of conventional contrast media solutions with high safety. Automated intravascular injection of various gases enables the development of novel imaging approaches with multiple imaging modalities (CT, ultrasound, MRI, and others). In particular, sequential and concomitant accumulation of intravenously injected gases in the pulmonary microvasculature and in the alveoli during single breath-hold offers a potential self-enhancing mechanism for direct perfusion imaging. We propose to develop an instrument for safe intravenous gas injection of gases in simulations and in the pulmonary vasculature of animals. Our goal is to realize the potential of automated gas injection as an alternative to liquid intravascular contrast and achieve greater safety, better imaging performance, and possible reduction or elimination of radiation. The performance of a prototype gas injector will be tested for reliable and safe delivery of CO2, nonpolarized stable Xe, and hyperpolarized Xe in an ex-vivo flow circuit. In vivo imaging performance will be evaluated and optimized using temporal Volumetric Image Display and Analysis in pigs without and with pulmonary emboli. Electron beam cine-CT will be used with injections of CO2 and stable Xe, MRI will be used with injections of hyperpolarized Xe. On completion, this project will provide a well characterized automated gas injection device with known imaging performance on administration of various gases. This device should find application for assessment of pulmonary embolism with contrast angiography when noninvasive and potentially radiation free three- dimensional vascular imaging modalities are preferred. The methodology can be expanded to gas- enhanced imaging of the entire vasculature and endoluminal gas-enhanced therapeutic applications.

血管内注射造影剂是事实上的标准诊断血管闭塞性疾病的方法。这些代理有渗透压、化学毒性和过敏风险。气体替代为造影剂具有显着的潜力来避免这些公认的传统造影剂解决方案的局限性，安全性高。自动血管内注射各种气体使得开发具有多种成像模式的新型成像方法（CT、超声波、MRI 等）。特别是，顺序和静脉注射气体同时在体内积聚单次屏气期间的肺微血管和肺泡为直接灌注提供了潜在的自我增强机制成像。我们建议开发一种安全静脉气体注射仪器模拟和动物肺血管系统中的气体。我们的目标是实现自动气体注射作为一种技术的潜力替代液体血管内造影剂并实现更高的安全性，更好的成像性能，并可能减少或消除辐射。将测试气体喷射器原型的性能用于可靠、安全地输送 CO2、非极化稳定 Xe，以及离体流动回路中的超极化 Xe。体内成像将使用时间体积来评估和优化性能无肺栓塞和有肺栓塞的猪的图像显示和分析。电子束电影 CT 将使用注射 CO2 和稳定 Xe， MRI 将与注射超极化 Xe 一起使用。完成后，该项目将提供一个特征良好的自动化具有已知给药成像性能的气体注射装置各种气体。该设备应找到评估申请无创和对比血管造影对肺栓塞的诊断潜在的无辐射三维血管成像方式是首选。该方法可以扩展到气体整个脉管系统和腔内气体增强的增强成像治疗应用。