HCV TRANSMISSION: SEX, VIOLENCE ALCOHOL & DRUG USE

HCV 传播：性、暴力、酒精

基本信息

批准号：
6190942
负责人：
MARCIA RUSSELL
金额：
$ 38.44万
依托单位：
PACIFIC INSTITUTE FOR RES AND EVALUATION
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-20 至 2003-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6190942
关键词：
accident proneness alcoholism /alcohol abuse behavioral /social science research tag clinical research communicable disease transmission disease /disorder proneness /risk hepatitis C hepatitis C virus high risk behavior /lifestyle human subject polymerase chain reaction sex behavior substance abuse related behavior violence

项目摘要

DESCRIPTION (adapted from the application) Disproportionate numbers of alcohol and drug users are infected with Hepatitis C virus (HCV). Although the majority of new cases appear to result from sharing contaminated drug paraphernalia, approximately 20% are attributed to sexual contact with an infected person. However, the HCV infectivity of semen and saliva is controversial. Based on evidence that alcohol and drug use are associated with high-risk sexual behavior (e.g., multiple sexual partners, a history of sexually transmitted diseases, and anal sex), violent behavior, and accidental injuries, we postulate that: 1) heavy drinking and other drug use increase HCV transmission via blood-to-blood contact in the context of sexual and other intimate interactions by promoting exposure to menstrual blood and bleeding caused by minor and major trauma and 2) heavy alcohol consumption may promote HCV transmission by depressing the immune system, increasing serum HCV RNA levels. We propose to assess lifetime and current drinking patterns, other drug use, and alcohol/drug-related behavior associated with possible blood-to-blood contact in the context of sexual, intimate situations in 16 STD clinic clients, 400 positive for anti-HCV and 1200 negative. Serum levels of HCV RNA will be assessed in anti-HCV+ clients by polymerase chain reaction. The relations between-alcohol/drug use and HCV status and the potential mediating effects of blood-to-blood contact related to high-risk sexual behavior, sexual victimization, domestic and other violence, accidental injuries, and unsafe drug use will be investigated us hierarchical regression analytic techniques; interaction terms will be used to investigate gender and racial differences in these relations. Cluster analysis will be employed to identify behavioral typologies associated with HCV status. Finally, the influence of lifetime and current drinking patterns on serum HCV RNA levels will be investigated, taking into account the effects of diet, smoking, and concomitant infections.

描述（改编自应用程序）酗酒和吸毒者感染肝炎的人数不成比例 C病毒（HCV）。尽管大多数新病例似乎是由于共享造成的受污染的吸毒用具，大约 20% 归因于性行为与感染者接触。然而，精液和 HCV 的传染性唾液是有争议的。基于酒精和药物使用的证据与高风险性行为有关（例如，多个性伴侣、性传播疾病史和肛交）、暴力行为以及意外伤害，我们假设：1）大量饮酒和使用其他药物性行为中通过血液接触增加丙型肝炎病毒传播通过促进接触经血和其他亲密互动轻微和重大创伤引起的出血以及 2) 大量饮酒可能通过抑制免疫系统、增加血清 HCV 来促进 HCV 传播 RNA水平。我们建议评估一生和当前的饮酒模式、其他药物使用情况、以及与可能的血液对血液相关的酒精/药物相关行为 16 名 STD 诊所客户在性、亲密情况下的接触， 400 人抗 HCV 阳性，1200 人阴性。 HCV RNA 的血清水平将为通过聚合酶链反应对抗 HCV+ 患者进行评估。关系酒精/药物使用与 HCV 状态之间以及潜在的中介作用与高危性行为、性行为相关的血液接触受害、家庭暴力和其他暴力、意外伤害和不安全将使用分层回归分析技术对药物使用情况进行调查；交互术语将用于调查性别和种族差异这些关系。将采用聚类分析来识别行为与 HCV 状态相关的类型。最后，寿命的影响将调查当前饮酒模式对血清 HCV RNA 水平的影响，采取考虑饮食、吸烟和伴随感染的影响。