COOPERATIVE INTERAREAL PROCESSING OF VISUAL CONTOURS

视觉轮廓的协作域间处理

• 批准号: 2882926
• 负责人: ANNA W. ROE
• 金额: $ 23.08万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2882926
• 关键词: Aotus; Macaca; behavioral /social science research tag; cats; cell cell interaction; electrophysiology; histology; microelectrodes; neural information processing; neuroanatomy; optics; synapses; visual cortex; visual perception; visual stimulus

The mammalian cerebral cortex is characterized by multiple cortical areas, each with a separate representation of the sensory world. However, the role of multiple representation in sensory information processing is unknown. As a prelude to understanding how multiple cortical areas cooperatively process visual percepts, this proposal aims to study contour representation within V2 (the second visual cortical area) and its interaction with contour representation in V1 (primary visual cortex). Orientation selective cells in V1 are well known to be responsive to luminance contrast edges. However, many visual contours are not defined by luminance contrast but rather by higher order features (such as occluded contours or texture pattern borders). Area V2, the second major stage of visual cortical processing, is characterized by cells which prefer such higher order features. This proposal will explore the idea that different cortical areas process different levels or abstractions of visual contours and examine how these separate representations interact. Specifically, the organization and interactions between cells responsive to real contours and those responsive to higher order contours will be examined. These circuitries will be examined for each of the color, form, and disparity domains which together comprise V2. The stated goals will be achieved by using a combination of optical imaging, electrophysiological, and anatomical methods. V1-V2 interactions will be studied with both cross correlation methods and optical imaging of V1-V2 activation in response to "spot" stimuli (a functional tract tracing method); these will be compared with connectivity patterns revealed anatomically. In addition, differences in contour saliency due to geometrical or featural characteristics will he related to stimulus- related changes in interaction patterns. By elucidating the neural circuitry underlying contour perception in V1 and V2, this research will offer insight into whether different cortical areas mutually reinforce the same information (i.e. interactions between similarly oriented real and higher order contour cells) or whether a more hierarchical relationship exists in which the outputs of one area are used to construct a quite different representation in another area (interactions between differently oriented real and higher order contour cells). Alternatively, different strategies could be used under different contexts, a possibility that would be supported by stimulus-related changes in connectivity or activation of different populations of contour cells in V2.

哺乳动物大脑皮层的特点是具有多个皮层 每个区域都有一个单独的感官世界代表。然而， 多重表征在感觉信息处理中的作用是 未知。作为了解多个皮质区域如何 合作处理视觉感知，该提案旨在研究 V2（第二视觉皮层区域）内的轮廓表示和 它与 V1 中轮廓表示的交互（主要视觉 皮层）。 V1 中的定向选择性细胞众所周知 对亮度对比度边缘敏感。然而，许多视觉轮廓 不是由亮度对比度定义，而是由高阶特征定义 （例如被遮挡的轮廓或纹理图案边界）。 V2区， 视觉皮层处理的第二个主要阶段，其特点是 更喜欢这种高阶特征的细胞。本提案将探讨 不同的皮质区域处理不同级别的想法或 视觉轮廓的抽象并检查它们如何分开 表征相互作用。具体来说，组织和互动 对真实轮廓敏感的细胞和对更高轮廓敏感的细胞之间 将检查订单轮廓。将检查这些电路 每个颜色、形状和视差域共同构成 V2。既定目标将通过使用光学组合来实现 成像、电生理学和解剖学方法。 V1-V2 相互作用 将使用互相关方法和光学成像进行研究 V1-V2 激活响应“点”刺激（功能束） 追踪方法）；这些将与连接模式进行比较 解剖学上揭示。此外，由于轮廓显着性的差异 几何或特征特征将与刺激有关 交互模式的相关变化。 通过阐明 V1 轮廓感知的神经回路 和 V2，这项研究将深入了解不同的皮质是否 区域相互强化相同的信息（即区域之间的相互作用） 类似定向的实数和高阶轮廓单元）或者是否有更多 存在等级关系，其中一个区域的输出是 用于在另一个区域构建完全不同的表示 （不同方向的实数和高阶轮廓之间的相互作用 细胞）。或者，在不同的情况下可以使用不同的策略 背景下，刺激相关的可能性将得到支持 不同轮廓群体的连通性或激活的变化 V2 中的细胞。