PREVENTION FOR FAMILIES WITH AFFECTIVE DISORDER

情感障碍家庭的预防

• 批准号: 6013547
• 负责人: William R. Beardslee
• 金额: $ 1.44万
• 依托单位: JUDGE BAKER CHILDREN'S CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6013547
• 关键词: adolescence (12-20); behavior modification; behavior test; behavioral /social science research tag; child behavior; child mental disorders; cognitive behavior therapy; disease /disorder proneness /risk; family; family medicine; family structure /dynamics; health education; human subject; interview; longitudinal human study; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; middle childhood (6-11); mood disorders; questionnaires; self concept; statistics /biometry

Depression in adults is a public health problem of major proportions. Children of parents with affective will experience depression at alarmingly high rates; as much as 50% by the end of adolescence. This application requests funds to continue the evaluation of the efficacy of two forms of interventions for prevention of depression for youngsters in families with affective disorder who have been enrolled at ages 8-15, before the age of highest risk. We propose to do this by continuing the serial longitudinal assessment of our sample of youngsters and their parents through the age of very high risk for onset of affective disorder, that is adolescence into early adulthood. The average age of the youngsters at the end of the current funding period will be 14.8, and at the end of the proposed period 18.8. Through both a pilot study (begun in 1989) and our current five-year RO1 (begun in 1992), a sample of 100 families (132 children, 183 parents) have been enrolled, randomized, and assessed. All have or will shortly receive one of two interventions, before the end our current funding in April, 1997. The two interventions were designed to be compatible with the practices of a wide range of professionals, given the high prevalence of depression in both medical and mental health settings. The interventions are: (1) a manual-based program involving six to ten sessions with a family, conducted by a clinician; and (2) presentation of the same material in a standardized multiple family lecture-group discussion format. Our central hypothesis is that both interventions will help families, but there will be a greater effect in the clinician-facilitated intervention. Both children and parents have been assessed blind to one another with a battery of standard instruments derived from risk research, supplemented by an instrument designed to assess response to intervention, administered initially and then every 8 months thereafter. An extremely high rate of follow-up participation (over 95% after 18 months) has been obtained. Analyses of data to date indicate that in both the pilot sample and in one half of the NIMH sample both interventions have been well tolerated and have had positive effects on family functioning, but significantly greater effects have been reported for both parents and children in the clinician-facilitated intervention 70 weeks after intervention. The pilot families, who have been followed for three to four years, have reported sustained effects. Differences between groups were also sustained.

成人抑郁症是一个重大的公共卫生问题 比例。 有情感的父母的孩子会经历 抑郁症发病率高得惊人；年底前高达50% 青春期。该申请要求资金以继续 评估两种干预措施的效果 预防情感家庭中青少年的抑郁症 年龄在 8-15 岁之前就已入组的疾病患者 风险最高。我们建议通过继续系列来做到这一点 对我们的青少年样本及其他们的纵向评估 父母处于情感发作风险极高的年龄 障碍，即青春期到成年早期。平均年龄 当前资助期结束时的青少年人数将是 14.8，以及在拟议期间结束时 18.8。通过两个 试点研究（始于 1989 年）和我们当前的五年 RO1（始于 1992），100个家庭的样本（132个孩子，183个父母） 已入组、随机化和评估。全部已经或很快就会 在我们当前的结束之前接受两种干预措施之一 1997 年 4 月资助。这两项干预措施旨在 与广泛的专业人士的实践兼容， 鉴于抑郁症在医学和精神方面的患病率很高 健康设置。干预措施是：（1）基于手动的程序 涉及与家庭进行六到十次会议，由一名 临床医生； (2) 在同一材料中呈现相同的材料 标准化的多家庭讲座小组讨论形式。我们的 中心假设是这两种干预措施都会帮助家庭， 但在临床医生协助下会产生更大的效果 干涉。 儿童和家长都接受了盲测 彼此之间使用一组标准仪器衍生 风险研究，并辅以旨在评估的工具 对干预的反应，最初进行，然后每 8 次 此后几个月。极高的跟进率 已获得参与（18 个月后超过 95%）。 迄今为止的数据分析表明，在试点样本和 在 NIMH 样本的一半中，两种干预措施都效果良好 可以容忍并对家庭功能产生积极影响，但是 据报道，对父母双方的影响明显更大 和儿童接受临床医生协助的干预 70 周 干预后。一直被跟踪的飞行员家庭 三到四年内，报告了持续的影响。差异 组间也持续存在。