CARCINOGENS AND CHROMATIN STRUCTURE AND FUNCTION

致癌物和染色质结构与功能

• 批准号: 3166825
• 负责人: MARK E SMULSON
• 金额: $ 14.81万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-06-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3166825
• 关键词: ADP ribosylation; DNA repair; HeLa cells; adenosine diphosphate; alkylation; autoradiography; chemical carcinogen; chemical fingerprinting; endonuclease; enzyme mechanism; gel electrophoresis; human tissue; nicotinamide adenine dinucleotide; nitrosourea; nucleic acid sequence; nucleocapsid; nucleoproteins; nucleosomes; radiotracer; tissue /cell culture; tritium

Our main objectives are to continue our studies on carcinogens and chromatin along two broad lines: One dealing with relationships between poly ADP-ribosylation of chromosomal proteins and functions in DNA repair mechanisms; and secondly, to continue our studies on the overall importance of nucleosomal conformation on interactions of carcinogens with DNA.

我们的主要目标是继续我们对致癌物和染色质的研究 沿着两条宽线：一个处理poly之间的关系 染色体蛋白的ADP-核糖基化和DNA修复机制中的功能； 其次，继续我们研究核小体的总体重要性 致癌物与DNA相互作用的构象。