MAGNETIC MEASUREMENT OF HUMAN IRON STORES

人体铁储备的磁力测量

• 批准号: 3151464
• 负责人: JOHN W HARRIS
• 金额: $ 18.99万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151464
• 关键词: adult human (21+); alcoholism /alcohol abuse; biopsy; blood transfusion; cancer complication; chelation therapy; child (0-11); clinical biomedical equipment; computer assisted diagnosis; congenital hepatic porphyria; early diagnosis; ferritin; hemodialysis; hemosiderosis; hereditary hemochromatosis; human subject; iron disorder; iron storage disorder; liver cirrhosis; liver disorder diagnosis; magnetic field; metabolism disorder diagnosis; noninvasive diagnosis; orphan disease /drug; sickle cell anemia; sideroblastic anemia; thalassemia

The proposed research will use biomagnetic susceptometry - a method introduced and developed by our laboratories - to measure hepatic storage iron concentrations in patients with disorders of iron metabolism. At present, the results of non-invasive magnetic determinations and of the chemical analysis of hepatic tissue obtained by biopsy are quantitatively equivalent when body iron stores are normal or increased. With our new computer-enhanced, dual channel, superconducting quantum-interference device (SQUID) susceptometer, a computer controls the entire measurement procedure and automatically calculates the hepatic iron concentration. In effect, the susceptometric method provides an automated, safe, and non-invasive magnetic "biopsy" of liver ferritin and hemosiderin iron that is well accepted by patients. In patients with iron overload, magnetic studies permit accurate, direct, reliable, and repeated measurements of hepatic iron that are not possible with any other available method. Clinically, hepatic magnetic measurements will be used for the detection and serial monitoring of patients with iron overload. In hereditary hemochromatosis, magnetic determinations of hepatic iron stores can identify affected individuals at an early precirrhotic stage when conventional indirect measures of iron status (serum, ferritin, transferrin saturation) may be unreliable and make possible early, preventive phlebotomy therapy. Magnetic measurements provide a new means for rapidly determining the effectiveness of treatment programs (chelation, transfusion) in transfusional iron overload (thalassemia major, other refractory anemia). Studies using the new dual channel instrument have already provided new quantitative insights that make possible the prescription of optimal individualized chelation regimens for patients with transfusional iron overload. Other studies are directed toward evaluating the toxicity of iron in patients with sickle cell anemia transfused for the prevention of recurrent stroke and in patients with iron-loading anemias with non-transfusional iron excess. In porphyria cutanea tarda, the relationship of clinical manifestations to hepatic iron content will be assessed during phlebotomy therapy. The prevalence and magnitude of iron overload in alcoholic cirrhosis and in patients requiring chronic hemodialysis will be examined in our hospital population. The goal of our studies is to determine directly the quantitative relationship between the level of iron stores and the pathophysiologic manifestations of disorders of iron metabolism.

拟议的研究将使用生物磁斯伯特仪 - 一种方法 由我们的实验室引入和开发 - 测量肝存储 铁代谢疾病患者的铁浓度。 在 目前，非侵入性磁性测定的结果和 通过活检获得的肝组织的化学分析是定量的 当人体铁储存正常或增加时等效。 有了我们的新 计算机增强，双向通道，超导量子介入 设备（鱿鱼）启示仪，计算机控制整个测量 程序并自动计算肝铁浓度。 在 效果，苏斯特里计量法提供了一种自动化，安全和 肝铁蛋白和赤铁蛋白铁的非侵入性磁性“活检” 被患者接受。 在铁超负荷的患者中 研究允许准确，直接，可靠和重复测量 使用任何其他可用方法是不可能的肝铁。 临床上，将使用肝磁测量值进行检测 以及对铁超负荷患者的连续监测。 在世袭 血色素瘤，肝铁储存的磁性测定可以 在早期的先进阶段识别受影响的个体 传统的铁状态间接度量（血清，铁蛋白，转铁蛋白 饱和）可能是不可靠的，并使得早期可能 放血术疗法。 磁性测量为快速的新手段提供了新的手段 确定治疗计划的有效性（螯合， 输血）输血过载（Thalassexyaper，其他 难治性贫血）。 使用新的双通道仪器的研究 已经提供了新的定量见解，使得 针对患者的最佳个性化螯合方案的处方 输血铁超负荷。 其他研究旨在评估 铁对镰状细胞性贫血患者的毒性输血 预防复发性中风和铁负荷贫血患者 与非交易的铁过量。 在孢子虫cutanea tarda中 临床表现与肝铁含量的关系将是 在放血术治疗期间进行评估。 铁的患病率和大小 酒精性肝硬化和需要慢性的患者超负荷 血液透析将在我们的医院人群中检查。 我们的目标 研究是直接确定 铁储存水平和疾病的病理生理表现 铁代谢。