MAGNETIC MEASUREMENT OF HUMAN IRON STORES

人体铁储备的磁力测量

• 批准号: 3151464
• 负责人: JOHN W HARRIS
• 金额: $ 18.99万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151464
• 关键词: adult human (21+); alcoholism /alcohol abuse; biopsy; blood transfusion; cancer complication; chelation therapy; child (0-11); clinical biomedical equipment; computer assisted diagnosis; congenital hepatic porphyria; early diagnosis; ferritin; hemodialysis; hemosiderosis; hereditary hemochromatosis; human subject; iron disorder; iron storage disorder; liver cirrhosis; liver disorder diagnosis; magnetic field; metabolism disorder diagnosis; noninvasive diagnosis; orphan disease /drug; sickle cell anemia; sideroblastic anemia; thalassemia

The proposed research will use biomagnetic susceptometry - a method introduced and developed by our laboratories - to measure hepatic storage iron concentrations in patients with disorders of iron metabolism. At present, the results of non-invasive magnetic determinations and of the chemical analysis of hepatic tissue obtained by biopsy are quantitatively equivalent when body iron stores are normal or increased. With our new computer-enhanced, dual channel, superconducting quantum-interference device (SQUID) susceptometer, a computer controls the entire measurement procedure and automatically calculates the hepatic iron concentration. In effect, the susceptometric method provides an automated, safe, and non-invasive magnetic "biopsy" of liver ferritin and hemosiderin iron that is well accepted by patients. In patients with iron overload, magnetic studies permit accurate, direct, reliable, and repeated measurements of hepatic iron that are not possible with any other available method. Clinically, hepatic magnetic measurements will be used for the detection and serial monitoring of patients with iron overload. In hereditary hemochromatosis, magnetic determinations of hepatic iron stores can identify affected individuals at an early precirrhotic stage when conventional indirect measures of iron status (serum, ferritin, transferrin saturation) may be unreliable and make possible early, preventive phlebotomy therapy. Magnetic measurements provide a new means for rapidly determining the effectiveness of treatment programs (chelation, transfusion) in transfusional iron overload (thalassemia major, other refractory anemia). Studies using the new dual channel instrument have already provided new quantitative insights that make possible the prescription of optimal individualized chelation regimens for patients with transfusional iron overload. Other studies are directed toward evaluating the toxicity of iron in patients with sickle cell anemia transfused for the prevention of recurrent stroke and in patients with iron-loading anemias with non-transfusional iron excess. In porphyria cutanea tarda, the relationship of clinical manifestations to hepatic iron content will be assessed during phlebotomy therapy. The prevalence and magnitude of iron overload in alcoholic cirrhosis and in patients requiring chronic hemodialysis will be examined in our hospital population. The goal of our studies is to determine directly the quantitative relationship between the level of iron stores and the pathophysiologic manifestations of disorders of iron metabolism.

拟议的研究将使用生物磁敏感度测量法 - 一种方法 由我们的实验室推出和开发 - 用于测量肝储存 铁代谢紊乱患者的铁浓度。 在 目前，非侵入性磁力测定和 对活检获得的肝组织进行化学分析 当体内铁储存正常或增加时相当于。 与我们的新 计算机增强、双通道、超导量子干涉 装置（SQUID）感受计，计算机控制整个测量 程序并自动计算肝铁浓度。 在 效应，电纳法提供了一种自动化、安全且 肝铁蛋白和含铁血黄素铁的非侵入性磁“活检” 深受患者欢迎。 对于铁过载的患者，磁 研究允许准确、直接、可靠和重复的测量 肝铁是任何其他可用方法都无法实现的。 临床上会采用肝磁测量来检测 以及对铁超负荷患者的连续监测。 在遗传性 血色素沉着症，磁性测定肝铁储备可以 在早期肝硬化阶段识别受影响的个体 铁状态的常规间接测量（血清、铁蛋白、转铁蛋白 饱和）可能不可靠，并且可以尽早进行预防性 放血疗法。 磁测量提供了一种快速测量的新方法 确定治疗方案的有效性（螯合、 输血）输血铁超负荷（重型地中海贫血、其他 难治性贫血）。 使用新型双通道仪器的研究表明 已经提供了新的定量见解，使 为患者制定最佳个体化螯合方案 输血铁超负荷。 其他研究旨在评估 铁对镰状细胞性贫血患者输血的毒性 预防复发性中风和铁负荷性贫血患者 非输血铁过量。 在迟发性皮肤卟啉症中， 临床表现与肝铁含量的关系 在放血治疗期间进行评估。 铁的普遍性和含量 酒精性肝硬化和需要慢性治疗的患者超负荷 我们将在医院人群中进行血液透析检查。 我们的目标 研究的目的是直接确定各因素之间的数量关系 铁储备水平和疾病的病理生理表现 铁代谢的影响。