ENTERIC DISEASES IN A POPULATION AT RISK FOR AIDS

艾滋病高危人群中的肠道疾病

• 批准号: 3131699
• 负责人: JOHN G BARTLETT
• 金额: $ 23.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1987-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3131699
• 关键词: AIDS; Adenoviridae; Alphaherpesvirinae; Betaherpesvirinae; Candida albicans; Chlamydia trachomatis; Chlamydiaceae; Clostridium; Coccidia; Coxsackievirus; Cryptosporidium; Entamoeba histolytica; Giardia; Neisseria gonorrhoeae; Rotavirus; Salmonella; Shigella; Treponema; Vibrio; Yersinia pestis disease; acute infectious nonbacterial gastroenteritis; biopsy; contrast media; delayed hypersensitivity; disease /disorder proneness /risk; endoscopy; enteric bacteria; enteritis; enzyme linked immunosorbent assay; epidemiology; gastroenteritis; gastrointestinal imaging /visualization; homosexuals; human subject; immunologic skin test; longitudinal human study; male; microorganism immunology; parasitic disease diagnosis; serotyping; tissue /cell culture

Prior studies suggest that intestinal disease, primarily proctitis and proctocolitis, is a frequent problem in homosexual men. A variety of pathogens have been implicated including commonly-recognized transmissible agents of enteric disease as well as multiple organisms recognized as agents of sexually transmitted diseases. More recent work also indicates that diarrhea and opportunistic infection are common features of AIDS and the AIDS-related complex. The purpose of our study will be to examine enteric pathogens and enteric disease in homosexual men, a group at risk for AIDS. The source of participants will be another study entitled "Natural History of AIDS in Homosexual Men". This parent study involves a cohort of 1,000 homosexual men from the Greater Baltimore area who are followed a six month intervals for three years with the major goal of identifying variables associated with altered immune status and the risk of developing immune defects including AIDS. Our studies will include analyses of rectal swabs or stools to detect 20 infectious agents including N. gonorrhoeae, T. pallidum, C. trachomatis (including LGV strains), H. simplex, CMV, Giardia, E. histolytica, Cryptosporidium, Isospora, Salmonella, Shigella, Campylobacter, Aeromonas, C. difficile, Yersinia, Vibrio, rotavirus, adenovirus, Coxsackie viruses and C. albicans. There will be three studies: 1) a prevalence study involving cross-sectional analysis from a randomly selected population of 200 patients; 2) a case-control study to define the incidence, clinical characteristics and agents of symptomatic disease among the 1,000 participants followed prospectively for 3 years; 3) an epidemiologic study designed to detect carriage of pathogens in sexual contacts of patients with symptomatic disease; and 4) an intensive evaluation of intestinal disease in participants and patients that develop AIDS for AIDS-related complex. A unique aspect of this work is that extensive data will be obtained in the parent study to define behavioral practices and to define immune function of participants. This information, which does not require separate funding, will be included in data analysis of the present study to identify risk factors associated with intestinal carriage or symptomatic disease and to examine possible relationships between enteric infections and alterations in the immune system.

先前的研究表明，肠道疾病，主要是直肠炎和 直肠结肠炎是同性恋男性中常见的问题。 各种 涉及的病原体包括公认的传染性病原体 肠道疾病以及多种生物体被认为是 性传播疾病的媒介。 最近的工作还表明 腹泻和机会性感染是艾滋病的共同特征 与艾滋病有关的综合体。 我们研究的目的是检验 男性同性恋者的肠道病原体和肠道疾病，这是一个高危人群 对于艾滋病。 参与者的来源将是另一项名为 “同性恋男性艾滋病的自然史”。 这项家长研究涉及 来自大巴尔的摩地区的 1,000 名同性恋男子组成的队列 三年内每隔六个月进行一次，主要目标是 识别与免疫状态改变和风险相关的变量 出现免疫缺陷，包括艾滋病。 我们的研究将包括对直肠拭子或粪便的分析，以检测 20 传染性病原体，包括淋病奈瑟菌、梅毒螺旋体、沙眼衣原体 （包括 LGV 菌株）、H. simplex、CMV、Giardia、E. histolytica、 隐孢子虫、等孢子虫、沙门氏菌、志贺氏菌、弯曲杆菌、气单胞菌、 艰难梭菌、耶尔森氏菌、弧菌、轮状病毒、腺病毒、柯萨奇病毒 和白色念珠菌。 将进行三项研究：1) 患病率研究 涉及随机选择的总体的横断面分析 200名患者； 2）病例对照研究，以确定发病率、临床情况 1,000 种症状性疾病的特征和诱因 参与者前瞻性随访 3 年； 3）流行病学研究 旨在检测患者性接触中携带的病原体 有症状的疾病； 4) 肠道的强化评估 患有艾滋病的参与者和患者患有艾滋病相关疾病 复杂的。 这项工作的一个独特之处在于，将收集大量数据 在家长研究中获得来定义行为实践并定义 参与者的免疫功能。 这些信息不需要 单独的资金，将包含在本研究的数据分析中 识别与肠道携带或症状相关的危险因素 疾病并检查肠道感染之间可能的关系 和免疫系统的改变。

项目成果

Recovery of Campylobacter species from homosexual men.

从同性恋男性中回收弯曲杆菌属。

• DOI: 10.1093/infdis/158.2.464
• 发表时间: 1988
• 期刊: The Journal of infectious diseases
• 作者: Laughon,BE;Vernon,AA;Druckman,DA;Fox,R;Quinn,TC;Polk,BF;Bartlett,JG
• 通讯作者: Bartlett,JG

Prevalence of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome.

患有和不患有获得性免疫缺陷综合症的同性恋男性肠道病原体的患病率。

• DOI: 10.1016/0016-5085(88)90557-4
• 发表时间: 1988
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Laughon,BE;Druckman,DA;Vernon,A;Quinn,TC;Polk,BF;Modlin,JF;Yolken,RH;Bartlett,JG
• 通讯作者: Bartlett,JG