1H AND 31P MRSI OF AGING BRAIN AND SENILE DEMENTIA

大脑老化和老年痴呆症的 1H 和 31P MRSI

• 批准号: 3122875
• 负责人: MICHAEL W WEINER
• 金额: $ 24.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3122875
• 关键词: acidity /alkalinity; acute renal failure; clinical biomedical equipment; coronary occlusion /thrombosis; deuterium; diagnosis design /evaluation; disease /disorder model; electronic pacemaker; electronic spectra; exercise; glomerular filtration; head /neck neoplasm; heart contraction; heart metabolism; heart rate; heart transplantation; human subject; human therapy evaluation; hypertrophic myocardiopathy; ischemia; kidney metabolism; lactates; magnetic resonance imaging; molecular oncology; molecular pathology; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; nuclear magnetic resonance spectroscopy; phantom model; phosphates; phosphorus; squamous cell carcinoma; stable isotope; swine; ultrasonography

The goal of this project is to determine the metabolic disturbances within tissue produced by disease and therapy. High- energy phosphates, pH, lactate, and other metabolites will be measured in surface tumors, heart, and kidneys of human patients, using 31P and 1H NHR. Both Bo and B1 localization techniques will be developed, simulated, tested on phantoms, normal subjects, and patients. Cancer studies will examine the possibility that metabolic changes are a sensitive and early index of the response to therapy. These studies will begin with large superficial squamous cell carcinomas of the head and neck. After completing a survey to characterize metabolic composition, heterogeneity, and variability, pilot experiments will determine the effects and time course of chemo- and radiation therapy. A prospective trial will correlate the spectral changes with the ultimate response to therapy, determined by MRI, CT, and ultimate outcome. Heart studies are designed to test the hypothesis that disorders of cardiac energy metabolism may be responsible for functional abnormalities in cardiac disease. 31P and 1H NMR studies of coronary ischemia in the pig will be continued using surgically implanted coils. Spectral localization techniques will be developed using the pig and human subjects. The effects of exercise and pacing will be determined and the metabolic alterations produced by myocardiopathy, hypertrophy, transplant rejection, and ischemia will be examined. Human kidney studies are aimed at investigating the metabolic changes produced by acute tubular necrosis. Once localization techniques are developed, and the normal kidney is examined, the changes associated with acute tubular necrosis will be characterized. Renal function will be correlated with NMR results to determine if spectral changes predict the outcome, or the response to therapy in a series of patients with ATN.

该项目的目的是确定代谢 通过疾病和治疗产生的组织内部障碍。 高的- 能量磷酸盐，pH，乳酸和其他代谢产物将是 在人类患者的表面肿瘤，心脏和肾脏中测量 使用31p和1h NHR。 BO和B1本地化技术 将开发，模拟，对幻影进行测试，正常 受试者和患者。 癌症研究将检查可能性 这种代谢变化是敏感的早期索引 对治疗的反应。 这些研究将从大型 头部和颈部的浅表鳞状细胞癌。 后 完成一项调查以表征代谢组成， 异质性和可变性，试点实验将确定 化学和放射疗法的影响和时间过程。 一个 前瞻性试验将使频谱变化与 对治疗的最终反应，由MRI，CT和 最终结果。 心脏研究旨在测试 假设心脏能量代谢的疾病可能是 负责心脏病的功能异常。 31p 和1H NMR研究中的冠状动脉缺血研究将是 继续使用手术植入线圈。 光谱定位 技术将使用猪和人类受试者开发。 将确定运动和起搏的影响，并 心肌病，肥胖产生的代谢改变， 将检查移植排斥和缺血。 人类 肾脏研究旨在研究代谢变化 由急性管状坏死产生。 一旦本地化技术 开发，检查正常肾脏，变化 将表征与急性管状坏死有关的。 肾功能将与NMR结果相关以确定 如果光谱变化预测结果，或者对 一系列ATN患者的治疗。