Integrating genetics and high throughput genomics to identify genes underlying tomato QTL for metabolites that influence fruit quality. (TOMQML)
整合遗传学和高通量基因组学来识别影响果实品质的代谢物的番茄 QTL 基础基因。
基本信息
- 批准号:BB/G02491X/1
- 负责人:
- 金额:$ 47.12万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2009
- 资助国家:英国
- 起止时间:2009 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Fruits are an immensely important part of the human diet. Low fruit and vegetable intake is recognised as a major factor for increased risk of heart disease and certain cancers. Encouraging people to consume more fruit in their diet is not necessarily straight forward and depends on factors including cost and product quality. Some of the most important changes in fruit quality related to ripening involve the accumulation of primary metabolites such as sugars and acids which influence taste. Also alterations in the levels of secondary metabolites such as carotenoids and phenylpropanoids can have a significant impact on nutritional quality. The challenge is to understand how these individual ripening changes are controlled /modulated and develop commercially viable strategies for breeding novel and better fruit products. This project focuses on tomato as it is the most widely consumed fleshy fruit in the human diet, with a global value in excess of $10 bn. It has become the model for studying the development and ripening of fleshy fruits and a wealth of genetic and genomic resources are available. We will use a range of well characterised publicly available tomato lines and novel tomato genetic resources combined with a range of genetic and molecular approaches to identify the genes controlling tomato taste and the accumulation of health enhancing phytochemicals. In concert with these approaches, we will identify the links between major regulators of ripening and their associated metabolite changes. The project will make an important contribution to fundamental knowledge about the molecular basis of fruit ripening. The consortium consists of internationally recognized groups from universities and research institutes in Europe and the USA as well as a global supplier of vegetable seeds, collectively ensuring a framework for innovative excellence.
水果是人类饮食中非常重要的一部分。水果和蔬菜摄入量低被认为是增加心脏病风险和某些癌症的主要因素。鼓励人们在饮食中消耗更多的水果并不一定是直截了当的,并且取决于包括成本和产品质量在内的因素。与成熟相关的水果质量最重要的变化涉及主要代谢物的积累,例如影响味道的糖和酸。同样,二级代谢物(例如类胡萝卜素和苯丙烷)水平的改变也会对营养质量产生重大影响。面临的挑战是了解这些个人成熟的变化如何受到控制 /调制,并开发出可行的可行策略来繁殖新颖和更好的水果产品。该项目的重点是番茄,因为它是人类饮食中最广泛消耗的肉质水果,全球价值超过10亿美元。它已成为研究肉体水果的发展和成熟的模型,并且可以使用大量的遗传和基因组资源。我们将使用一系列具有良好特征的公开番茄品系和新型番茄遗传资源,并结合一系列遗传和分子方法来识别控制番茄味的基因以及健康增强植物化学物质的积累。与这些方法一致,我们将确定成熟的主要调节剂与它们相关的代谢物变化之间的联系。该项目将对有关果实成熟的分子基础的基本知识做出重要贡献。该财团由欧洲和美国大学和研究机构的国际认可的团体以及全球蔬菜种子供应商组成,共同确保了创新卓越的框架。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The tomato genome sequence provides insights into fleshy fruit evolution.
番茄基因组序列提供了对肉质果实进化的见解
- DOI:10.1038/nature11119
- 发表时间:2012-05-30
- 期刊:
- 影响因子:64.8
- 作者:Sato, Shusei;Tabata, Satoshi;Hirakawa, Hideki;Asamizu, Erika;Shirasawa, Kenta;Isobe, Sachiko;Kaneko, Takakazu;Nakamura, Yasukazu;Shibata, Daisuke;Aoki, Koh;Egholm, Michael;Knight, James;Bogden, Robert;Li, Changbao;Shuang, Yang;Xu, Xun;Pan, Shengkai;Cheng, Shifeng;Liu, Xin;Ren, Yuanyuan;Wang, Jun;Albiero, Alessandro;Dal Pero, Francesca;Todesco, Sara;Van Eck, Joyce;Buels, Robert M.;Bombarely, Aureliano;Gosselin, Joseph R.;Huang, Minyun;Leto, Jonathan A.;Menda, Naama;Strickler, Susan;Mao, Linyong;Gao, Shan;Tecle, Isaak Y.;York, Thomas;Zheng, Yi;Vrebalov, Julia T.;Lee, JeMin;Zhong, Silin;Mueller, Lukas A.;Stiekema, Willem J.;Ribeca, Paolo;Alioto, Tyler;Yang, Wencai;Huang, Sanwen;Du, Yongchen;Zhang, Zhonghua;Gao, Jianchang;Guo, Yanmei;Wang, Xiaoxuan;Li, Ying;He, Jun;Li, Chuanyou;Cheng, Zhukuan;Zuo, Jianru;Ren, Jianfeng;Zhao, Jiuhai;Yan, Liuhua;Jiang, Hongling;Wang, Bao;Li, Hongshuang;Li, Zhenjun;Fu, Fuyou;Chen, Bingtang;Han, Bin;Feng, Qi;Fan, Danlin;Wang, Ying;Ling, Hongqing;Xue, Yongbiao;Ware, Doreen;McCombie, W. Richard;Lippman, Zachary B.;Chia, Jer-Ming;Jiang, Ke;Pasternak, Shiran;Gelley, Laura;Kramer, Melissa;Anderson, Lorinda K.;Chang, Song-Bin;Royer, Suzanne M.;Shearer, Lindsay A.;Stack, Stephen M.;Rose, Jocelyn K. C.;Xu, Yimin;Eannetta, Nancy;Matas, Antonio J.;McQuinn, Ryan;Tanksley, Steven D.;Camara, Francisco;Guigo, Roderic;Rombauts, Stephane;Fawcett, Jeffrey;Van de Peer, Yves;Zamir, Dani;Liang, Chunbo;Spannagl, Manuel;Gundlach, Heidrun;Bruggmann, Remy;Mayer, Klaus;Jia, Zhiqi;Zhang, Junhong;Ye, Zhibiao;Bishop, Gerard J.;Butcher, Sarah;Lopez-Cobollo, Rosa;Buchan, Daniel;Filippis, Ioannis;Abbott, James;Dixit, Rekha;Singh, Manju;Singh, Archana;Pal, Jitendra Kumar;Pandit, Awadhesh;Singh, Pradeep Kumar;Mahato, Ajay Kumar;Dogra, Vivek;Gaikwad, Kishor;Sharma, Tilak Raj;Mohapatra, Trilochan;Singh, Nagendra Kumar;Causse, Mathilde;Rothan, Christophe;Schiex, Thomas;Noirot, Celine;Bellec, Arnaud;Klopp, Christophe;Delalande, Corinne;Berges, Helene;Mariette, Jerome;Frasse, Pierre;Vautrin, Sonia;Zouine, Mohamed;Latche, Alain;Rousseau, Christine;Regad, Farid;Pech, Jean-Claude;Philippot, Murielle;Bouzayen, Mondher;Pericard, Pierre;Osorio, Sonia;Fernandez del Carmen, Asuncion;Monforte, Antonio;Granell, Antonio;Fernandez-Munoz, Rafael;Conte, Mariana;Lichtenstein, Gabriel;Carrari, Fernando;De Bellis, Gianluca;Fuligni, Fabio;Peano, Clelia;Grandillo, Silvana;Termolino, Pasquale;Pietrella, Marco;Fantini, Elio;Falcone, Giulia;Fiore, Alessia;Giuliano, Giovanni;Lopez, Loredana;Facella, Paolo;Perrotta, Gaetano;Daddiego, Loretta;Bryan, Glenn;Orozco, Modesto;Pastor, Xavier;Torrents, David;van Schriek, Keygene N. V. Marco G. M.;Feron, Richard M. C.;van Oeveren, Jan;de Heer, Peter;daPonte, Lorena;Jacobs-Oomen, Saskia;Cariaso, Mike;Prins, Marcel;van Eijk, Michiel J. T.;Janssen, Antoine;van Haaren, Mark J. J.;Jo, Sung-Hwan;Kim, Jungeun;Kwon, Suk-Yoon;Kim, Sangmi;Koo, Dal-Hoe;Lee, Sanghyeob;Hur, Cheol-Goo;Clouser, Christopher;Rico, Alain;Hallab, Asis;Gebhardt, Christiane;Klee, Kathrin;Joecker, Anika;Warfsmann, Jens;Goebel, Ulrike;Kawamura, Shingo;Yano, Kentaro;Sherman, Jamie D.;Fukuoka, Hiroyuki;Negoro, Satomi;Bhutty, Sarita;Chowdhury, Parul;Chattopadhyay, Debasis;Datema, Erwin;Smit, Sandra;Schijlen, Eliog. W. M.;van de Belt, Jose;van Haarst, Jan C.;Peters, Sander A.;van Staveren, Marjo J.;Henkens, Marleen H. C.;Mooyman, Paul J. W.;Hesselink, Thamara;van Ham, Roeland C. H. J.;Jiang, Guoyong;Droege, Marcus;Choi, Doil;Kang, Byung-Cheol;Kim, Byung Dong;Park, Minkyu;Kim, Seungill;Yeom, Seon-In;Lee, Yong-Hwan;Choi, Yang-Do;Li, Guangcun;Gao, Jianwei;Liu, Yongsheng;Huang, Shengxiong;Fernandez-Pedrosa, Victoria;Collado, Carmen;Zuniga, Sheila;Wang, Guoping;Cade, Rebecca;Dietrich, Robert A.;Rogers, Jane;Knapp, Sandra;Fei, Zhangjun;White, Ruth A.;Thannhauser, Theodore W.;Giovannoni, James J.;Angel Botella, Miguel;Gilbert, Louise;Gonzalez, Ramon;Goicoechea, Jose Luis;Yu, Yeisoo;Kudrna, David;Collura, Kristi;Wissotski, Marina;Wing, Rod;Schoof, Heiko;Meyers, Blake C.;Gurazada, Aishwarya Bala;Green, Pamela J.;Mathur, Saloni;Vyas, Shailendra;Solanke, Amolkumar U.;Kumar, Rahul;Gupta, Vikrant;Sharma, Arun K.;Khurana, Paramjit;Khurana, Jitendra P.;Tyagi, Akhilesh K.;Dalmay, Tamas;Mohorianu, Irina;Walts, Brandon;Chamala, Srikar;Barbazuk, W. Brad;Li, Jingping;Guo, Hui;Lee, Tae-Ho;Wang, Yupeng;Zhang, Dong;Paterson, Andrew H.;Wang, Xiyin;Tang, Haibao;Barone, Amalia;Chiusano, Maria Luisa;Ercolano, Maria Raffaella;D'Agostino, Nunzio;Di Filippo, Miriam;Traini, Alessandra;Sanseverino, Walter;Frusciante, Luigi;Seymour, Graham B.;Elharam, Mounir;Fu, Ying;Hua, Axin;Kenton, Steven;Lewis, Jennifer;Lin, Shaoping;Najar, Fares;Lai, Hongshing;Qin, Baifang;Qu, Chunmei;Shi, Ruihua;White, Douglas;White, James;Xing, Yanbo;Yang, Keqin;Yi, Jing;Yao, Ziyun;Zhou, Liping;Roe, Bruce A.;Vezzi, Alessandro;D'Angelo, Michela;Zimbello, Rosanna;Schiavon, Riccardo;Caniato, Elisa;Rigobello, Chiara;Campagna, Davide;Vitulo, Nicola;Valle, Giorgio;Nelson, David R.;De Paoli, Emanuele;Szinay, Dora;de Jong, Hans H.;Bai, Yuling;Visser, Richard G. F.;Lankhorst, Rene M. Klein;Beasley, Helen;McLaren, Karen;Nicholson, Christine;Riddle, Claire;Gianese, Giulio
- 通讯作者:Gianese, Giulio
A genome-wide metabolomic resource for tomato fruit from Solanum pennellii.
- DOI:10.1038/srep03859
- 发表时间:2014-01-24
- 期刊:
- 影响因子:4.6
- 作者:Perez-Fons L;Wells T;Corol DI;Ward JL;Gerrish C;Beale MH;Seymour GB;Bramley PM;Fraser PD
- 通讯作者:Fraser PD
Regulation of ripening and opportunities for control in tomato and other fruits.
- DOI:10.1111/j.1467-7652.2012.00738.x
- 发表时间:2013-04
- 期刊:
- 影响因子:13.8
- 作者:G. Seymour;N. Chapman;B. L. Chew;J. Rose
- 通讯作者:G. Seymour;N. Chapman;B. L. Chew;J. Rose
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Graham Seymour其他文献
Inhibition of Cell Wall Degradation by Silver (I) Ions during Ripening of Tomato Fruit
- DOI:
10.1016/s0176-1617(89)80020-3 - 发表时间:
1989-06-01 - 期刊:
- 影响因子:
- 作者:
Robin Smith;Graham Seymour;Gregory A. Tucker - 通讯作者:
Gregory A. Tucker
Graham Seymour的其他文献
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{{ truncateString('Graham Seymour', 18)}}的其他基金
Targeted supply chain ethylene removal to control the development of fresh produce
有针对性地去除供应链乙烯,控制生鲜农产品的发展
- 批准号:
BB/M025918/1 - 财政年份:2015
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant
Understanding the Genetic Basis of Traits for Rootstock Improvement in Vegetable Crops
了解蔬菜作物砧木改良性状的遗传基础
- 批准号:
BB/L019655/1 - 财政年份:2014
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant
The validation, characterisation and translation of the outputs derived from network analysis and QTL mapping of tomato fruit quality traits (TomNET)
番茄果实品质性状网络分析和 QTL 定位 (TomNET) 输出的验证、表征和翻译
- 批准号:
BB/J015598/1 - 财政年份:2012
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant
Characterisation of tomato short RNAs involved in fruit development
参与果实发育的番茄短RNA的表征
- 批准号:
BB/G006199/1 - 财政年份:2009
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant
A Systems Biology Approach to the Elucidation of Metabolic Networks Underlying Health Based Quality Traits in Tomato Fruit.
阐明番茄果实健康品质特性背后的代谢网络的系统生物学方法。
- 批准号:
BB/F005539/1 - 财政年份:2008
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant
A molecular and genetic framework for understanding the regulation of cell adhesion during fruit softening
用于了解果实软化过程中细胞粘附调节的分子和遗传框架
- 批准号:
D20300/2 - 财政年份:2006
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant
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Integrating genetics and high throughput genomics to identify genes underlying tomato QTL for metabolites that influence fruit quality (TOMQML)
整合遗传学和高通量基因组学来识别番茄 QTL 中影响果实品质的代谢物的基因 (TOMQML)
- 批准号:
BB/G024901/1 - 财政年份:2009
- 资助金额:
$ 47.12万 - 项目类别:
Research Grant