SCOR IN CORONARY AND VASCULAR DISEASES

冠状动脉和血管疾病中的 SCOR

• 批准号: 3106451
• 负责人: BURTON E SOBEL
• 金额: $ 341.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106451
• 关键词: heart disorder diagnosis; myocardial ischemia /hypoxia

This multidisciplinary investigation of the pathogenesis, progression, and favorable modification of ischemic heart disease involves 27 investigators from 13 departments engaged in 11 research projects and 5 cores laboratories. Coronary vascular pathogenetic mechanisms are the focus of studies of attenuation of ultrasound, contractile properties, and prostaglandin metabolism in normal and diseased vessels. Improved quantification of regional myocardial ischemia and infarction are being pursued by delineation of processes governing release and disappearance of biochemical markers of necrosis (MB and mitochondrial CK) and the distribution of positron-emitting tracers detected by computer reconstruction tomography. Etiological roles of amphipathic lipids and regional adrenergic stimulation in the genesis of malignant dysrhythmia and of calcium flux in the precipitation of cell death in myocardium and the microvasculature will be characterized to provide a basis for more effective prophylaxis and therapy. Clinical projects are devoted to improved detection of regional myocardial ischemia and infarction with positron tomography; characterization of early recurrent infarction and identification of the roles of implicated etiological factors such as platelets and coronary vasospasm with enzymatic, scintigraphic, and tomographic approaches; and identification of biochemical and physiological determinants of early and late dysrhythmia including the extent of initial infarction and prevailing concentrations of circulating amphipathic lipids in patients at rest and with exercise. Studies involve several levels of biological organization including isolated cells, vessels and myocardium in vitro, isolated perfused hearts, experimental animal preparations, and patients. Although the scope is broad, the techniques required have been implemented, verified, and in several cases developed during the initial grant interval with each project therefore predicated on a substantial base of information already acquired.

对发病机理，进展和 缺血性心脏病的有利修饰涉及27位来自 13个部门从事11个研究项目和5个核心实验室。 冠状动脉致病机制是研究的重点 超声，收缩物业和前列腺素代谢的衰减 在正常和患病的血管中。 改善区域心肌的定量 通过划定程序的划分，正在追求缺血和梗塞 坏死的生化标志物的释放和消失（MB和 线粒体CK）和由正电子发射示踪剂的分布 计算机重建断层扫描。 两亲性脂质的病因作用 区域肾上腺素能刺激在恶性心律失常和 钙通量在心肌中细胞死亡的沉淀中 微脉管系统将被特征为提供更有效的基础 预防和治疗。 临床项目致力于改进的检测 区域心肌缺血和正电子层析成像梗塞； 早期复发性梗塞的表征和角色的识别 涉及的病因因素，例如血小板和冠状动脉血管痉挛 酶促，闪烁图和断层扫描方法；和识别 早期和晚期心律失常的生化和生理决定因素 包括初始梗塞和普遍浓度的程度 在休息和运动中循环植物性脂质。 研究 涉及几个级别的生物组织，包括孤立的细胞， 血管和心肌体外，孤立的灌注心脏，实验动物 准备工作和患者。 虽然范围很广，但是这些技术 所需的已实施，验证，并且在几种情况下开发 因此，每个项目的初始赠款间隔是基于 已经获得的大量信息基础。