PATTERNS, PARTIAL KNOWLEDGE, AND TEST INTERPRETATION

模式、部分知识和测试解释

基本信息

批准号：
3074635
负责人：
PETER E POLITSER
金额：
$ 5.23万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-10-01 至 1988-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3074635
关键词：
carcinoembryonal antigen creatine kinase decision making diagnosis quality /standard disease /disorder model health care quality heart disorder diagnosis mathematical model model design /development myocardial infarction neoplasm /cancer immunodiagnosis patient care planning physicians problem solving

项目摘要

There is an urgent need to better understand the value of diagnostic tests. Their use is critical to timely and appropriate selection of medical treatment. This project investigates potential test interpretation aids based on partial knowledge about the statistical relations between serial tests. One method is based upon a concept to be called contingent information display. This involves using mathematical transformations of test patterns to remove redundancies, contingent on the diagnostic hypotheses being considered. One experiment to test this would would randomly assign physicians to one of three experimental groups, given different displays of serial creatine phosphokinase (CPK) assays to detect reinfarction or extension of an acute myocardial infarction. The hypothesis is that physicians' predictions of extension will be improved with transformed displays. A second method attempts to improve the interpretation of serial tests by clarifying the relevance of pattern features rather than by clarifying their display. An experiment will test whether logical explanations of statistical parameters describing these features improve the assessment of serial carcinoembryonic antigen (CEA) assays to detect a recurrence of colorectal cancer. Various other applications (multiple serum enzymes in myocardial infarction, radionuclide scan patterns) also are planned.

迫切需要更好地了解诊断的价值测试。它们的使用对于及时且适当的选择至关重要医疗。该项目调查了潜在的测试解释基于关于统计关系的部分知识的辅助串行测试。一种方法是基于一个称为偶然的概念信息显示。这涉及使用数学转换删除冗余的测试模式，取决于诊断考虑假设。一个测试这将会的实验会给定的三个实验组之一，随机分配医师串行肌酸磷酸激酶（CPK）测定的不同显示以检测急性心肌梗塞的重新施加或延伸。这假设是医师对扩展的预测将得到改善带有变换的显示器。第二种方法试图改善通过阐明模式的相关性来解释串行测试功能而不是澄清其显示器。实验将测试统计参数描述这些参数的逻辑解释是否功能改善了连续癌症抗原（CEA）的评估检测结直肠癌复发的测定。其他应用（心肌梗塞，放射性核素中的多种血清酶还计划扫描模式）。