CORE--CYTOGENETICS

核心--细胞遗传学

• 批准号: 6203202
• 负责人: JOHN R MCGILL
• 金额: $ 13.16万
• 依托单位: CTRC RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203202
• 关键词: biomedical facility; cell line; comparative genomic hybridization; cytogenetics; fluorescent in situ hybridization; genetic mapping; human genetic material tag; human tissue; karyotype; neoplasm /cancer genetics; biomedical facility; cell line; comparative genomic hybridization; cytogenetics; fluorescent in situ hybridization; genetic mapping; human genetic material tag; human tissue; karyotype; neoplasm /cancer genetics

Description: (Applicant's Description) The goal of the Genetics Resource will be to provide high quality genetic services related to all aspects of cancer research and to provide cancer genetics expertise and information to SACI investigators. The objective of this core is to provide comprehensive genetic studies on research specimens and to serve as a genetic resource facilitating interactions to enhance ongoing program collaborations. The Genetic Resource will offer the following services: 1. Standard cytogenetic analysis of tumor specimens and cell lines; banding and karyotyping. 2. FISH (fluorescent in situ hybridization) to detect chromosomal numerical and/or structural changes from metaphase and interphase nuclei. 3. Gene mapping by FISH localization of large insert probes (or radio-labeling of small probes). 4. Chromosome microdissection and microcloning. 5. Comparative genomic hybridization (CGH) of tumor cells. 6. Technical improvements for genetic analysis and technical expertise and facilities for implementation of new molecular techniques as they are developed. 7. Establish a new core service of scientific expertise in cancer genetics to foster program and investigator collaborations, assist in patient recruitment, data acquisition, protocol development and informed consent.

描述：（申请人的描述）遗传资源的目标 将提供与 癌症研究并提供癌症遗传学专业知识和信息 致Saci调查人员。该核心的目的是提供 有关研究标本的全面遗传研究，并充当 遗传资源促进相互作用以增强正在进行的计划 协作。 遗传资源将提供以下服务：1。 肿瘤标本和细胞系的细胞遗传学分析；乐队和 核分型。 2。鱼（荧光原位杂交）以检测 中期和/或结构变化的染色体数字和/或结构变化 相间核。 3。通过鱼类定位的大型插入物的基因映射 探针（或小探针的无线电标记）。 4。染色体微分解 和微量音。 5。肿瘤的比较基因组杂交（CGH） 细胞。 6。遗传分析和技术的技术改进 实施新分子技术的专业知识和设施 它们是开发的。 7.建立科学的新核心服务 癌症遗传学专业知识培养计划和研究人员 合作，协助患者招聘，数据获取，协议 发展和知情同意。