FUNCTIONAL ORGANIZATION OF MULTITENDONED FINGER MUSCLES

多腱手指肌肉的功能组织

• 批准号: 2714635
• 负责人: MARC H SCHIEBER
• 金额: $ 16.41万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-08 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714635
• 关键词: Primates; clinical research; electromyography; electronic stimulator; fingers; human subject; limb movement; muscle tension; neuroanatomy; neuromuscular function; neurophysiology; striated muscles; tendons

DESCRIPTION (Investigator's Abstract): The long term goal of this project is to understand how finger muscles produce individuated finger movements--those in which one or more fingers are moved without moving the others. Though each finger often is assumed to be moved by its own muscles, the extrinsic muscles that provide most of the flexing and extending power typically send tendons to multiple fingers. This anatomic fact presents a paradox: contractions of these multitendoned muscles should move multiple fingers simultaneously. Individuated flexion and extension of the fingers are hypothesized to be possible because: i) functional subdivisions within some multitendoned muscles may apply tension relatively selectively to some of the muscle's tendons, and ii) the forces produced by different multitendoned muscles may combine such that the net forces on each finger cause one digit to move while other digits are held still. The proposed studies specifically aim to address the following 6 questions: 1) Does each neuromuscular compartment in multitendoned finger muscles distribute tension to more than one tendon? 2) Do single motor units in these muscles distribute tension to multiple tendons? 3) Do mechanical interconnections between a muscle's tendons passively distribute tension to multiple fingers? 4) Do single motor units in human finger muscles act on multiple fingers? 5) Do humans co-contract several multitendoned finger muscles to produce individuated movement of one finger while holding other fingers still? 6) Can the mechanical action of several multitendoned muscles combine to move one finger while holding the other fingers still? These studies will result in an improved basic understanding of how multitendoned finger muscles function, which can translate into: i) production of useful finger movements by functional electrical stimulation of these muscles in patients with brain or spinal cord injury, ii) more accurate botulinum toxin injections for treatment of the hand's focal dystonias, and iii) more appropriate tendon transfers for reconstruction of a useful hand in patients debilitated by forearm trauma. Moreover, results of the proposed studies of muscles will have broad implications for understanding how finger movements are controlled by the central nervous system.

描述（调查员的摘要）：该项目的长期目标 是要了解手指肌肉如何产生个性化的手指 动作 - 一个或多个手指移动而不移动的动作 其他的。 尽管通常认为每个手指都被自己的肌肉移动，但 提供大部分弯曲和扩展功率的外部肌肉 通常将肌腱发送到多个手指。 这个解剖事实提出了 悖论：这些多端肌肉的收缩应移动多个 手指同时。 手指的个体屈曲和延伸 假设是可能的，因为：i） 某些多端肌肉可能相对有选择性地适用于某些张力 肌肉的肌腱，以及ii）不同的力 多端肌肉可能会结合，使每个手指上的净力 导致一个数字移动，而其他数字仍然保持静止。 提议 专门旨在解决以下6个问题：1） 多端指的手指肌肉中的神经肌肉室分布张力 对一个以上的肌腱？ 2）在这些肌肉中做单个电动机单元 将张力分发给多个肌腱？ 3）进行机械互连 在肌肉的肌腱之间被动地将张力分散到多个手指上？ 4）人手指肌肉中的单个运动单元是否用多个手指起作用？ 5）人类是否共同合同几个多端的手指肌肉来产生 一根手指的个体运动，握住其他手指？ 6） 几种多态肌肉的机械作用可以组合以移动 一根手指握住另一根手指吗？ 这些研究将导致 在改进了对多端手指肌肉的基本理解中 功能，可以转化为：i）产生有用的手指 这些肌肉在患者中的功能性电刺激运动 脑或脊髓损伤，ii）更准确的肉毒杆菌毒素 注射手的治疗手的局灶性肌张力障碍，iii）更多 适当的肌腱转移以重建患者有用的手 前臂创伤使人衰弱。 此外，提议的研究结果 肌肉将对理解手指运动有广泛的影响 由中枢神经系统控制。