ECHOCARDIOGRAPHIC RISK ASSESSMENT--CHEST PAIN PATIENTS

超声心动图风险评估——胸痛患者

• 批准号: 2734912
• 负责人: KIRSTEN E FLEISCHMANN
• 金额: $ 8.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2734912
• 关键词: angina pectoris; coronary intensive care; disease /disorder proneness /risk; echocardiography; electrocardiography; health care cost /financing; health care policy; heart surgery; hospital length of stay; hospital utilization; human subject; magnetic resonance imaging; medical complication; mitral valve; noninvasive diagnosis; outcomes research; pain; preoperative state; prognosis; statistics /biometry

Recent trends including development of new diagnostic and therapeutic modalities and increasing pressure to provide cost-effective care have made risk stratification and technology assessment increasingly important in cardiovascular research. This will be achieved through a series of studies exploring the utility of echocardiography in the risk stratification of patients with chest pain. We hypothesize that routinely available qualitative data from the echocardiogram can be used to risk stratify patients and that such data provide information above and beyond clinical data. Thus, by means of a prospective cohort study, we will: 1) Investigate the correlation between echocardiographic variables and the risk of a. complications during hospitalization; and b. long-term prognosis and functional status. 2) Determine whether echocardiographic variables add incremental risk stratification information after consideration of clinical and electrocardiographic data. 3) Develop and validate prospectively a predictive algorithm based on clinical, electrocardiographic and echocardiographic variables. 4) Assess the cost-effectiveness of performance of routine echocardiography in subsets of patients admitted for acute chest pain. In the latter part of the research program, these methodologies for technologies for technology assessment will be used to evaluate the role of cardiac imaging in other settings such as identification of preoperative predictors of outcome in patients undergoing mitral valve repair and replacement or assessment of aortic regurgitation with magnetic resonance imaging. This research should prove useful to both clinician and health policy maker.

最新趋势包括新诊断和治疗的开发 模式和提供具有成本效益的护理的压力越来越大 使风险分层和技术评估变得越来越重要 在心血管研究中。 这将通过一系列探索实用性的研究来实现 超声心动图在胸部疾病患者危险分层中的应用 疼痛。 我们假设常规可用的定性数据来自 超声心动图可用于对患者进行风险分层，并且此类数据 提供临床数据之外的信息。 因此，通过 一项前瞻性队列研究，我们将： 1) 研究超声心动图变量与 a. 的风险。住院期间出现并发症；和b。长期 预后和功能状态。 2) 确定超声心动图变量是否会增加风险 考虑临床和结果后的分层信息 心电图数据。 3) 开发并前瞻性验证基于 临床、心电图和超声心动图变量。 4) 评估日常执行的成本效益 对因急性胸痛入院的患者进行超声心动图检查。 在研究计划的后半部分，这些方法论 技术评估将用于评估技术的作用 在其他环境中进行心脏成像，例如识别 二尖瓣手术患者术前预后的预测因素 修复和更换或评估主动脉瓣关闭不全 磁共振成像。 这项研究应该对双方都有用 临床医生和卫生政策制定者。

项目成果

Weekend and holiday exercise testing in patients with chest pain.

周末和节假日对胸痛患者进行运动测试。

• DOI: 10.1046/j.1525-1497.1999.00274.x
• 发表时间: 1999
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Krasuski,RA;Hartley,LH;Lee,TH;Polanczyk,CA;Fleischmann,KE
• 通讯作者: Fleischmann,KE

Noninvasive imaging for the diagnosis of coronary artery disease: focusing the development of new diagnostic technology.

冠状动脉疾病诊断的无创成像：重点发展新诊断技术。

• DOI: 10.7326/0003-4819-131-9-199911020-00008
• 发表时间: 1999
• 期刊: Annals of internal medicine
• 影响因子: 39.2
• 作者: Hunink,MG;Kuntz,KM;Fleischmann,KE;Brady,TJ
• 通讯作者: Brady,TJ

Effect of diabetes mellitus on the presentation and triage of patients with acute chest pain without known coronary artery disease.

糖尿病对无已知冠状动脉疾病的急性胸痛患者的表现和分类的影响。

• DOI: 10.1016/s0002-9343(98)00327-1
• 发表时间: 1998
• 期刊: The American journal of medicine
• 作者: Lopez-Jimenez,F;Goldman,L;Johnson,PA;Polanczyk,CA;Cook,EF;Fleischmann,KE;Orav,EJ;Lee,TH
• 通讯作者: Lee,TH