BREAST CANCER IN WOMEN OF POLISH ANCESTRY

波兰血统女性的乳腺癌

基本信息

批准号：
2748825
负责人：
DOROTHY R PATHAK
金额：
$ 33.97万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-30 至 2002-07-31
项目状态：
已结题

项目摘要

Polish women experience breast cancer incidence (BC) one third that of U.S. women (age-adjusted rates per 100,000 in 1990; Warsaw City 37; Warsaw Rural 18; and in 1985-9; U.S. whites 94). Yet, recent studies of Polish immigrants to the West showed BC mortality rates for immigrants similar to the rates of the host county (standardized mortality ratios 91 (US), 100 (Australia), and 97 (England and Wales). No other population of migrants has shown so rapid a transition. The short time needed to express this changing risk for BC implicates modifiable environmental factors as significant determinants of risk. To evaluate the role of these factors, characteristics of place of origin and destination, change in habits, and when these changes occurred, as well as the individual's characteristics that influence BC risk, must be assessed. We propose to conduct two parallel, population-based case control studies of 20-74 years old incident BC cases in two populations: 1) Polish-born Immigrants, (378 cases and 378 controls) residing in Cook County and Detroit Metropolitan Area and 2) Polish-native, (500 cases and 500 controls) residing in Warsaw City. We hypothesize that components of both usual and past diet are associated with BC risk. We hypothesize that after adjusting for established risk factors BC risk will be increased by: (1) reduction in intake of specific types of foods (e.g. cruciferous vegetables, sauerkraut, root vegetables, whole grain breads and other cereals), and thus: 2) reduction in intake of phytochemicals (e.g. glucobrassicins, carotenoids, flavonoids, and antioxidants), and dietary fiber; and 3) increase in intake of meat, meat products and dietary fat; and 4) interaction among the dietary constituents in 1-3 above. Assessment of dietary intakes at three points in life (late 1980'S, premenarcheal, premenopausal) will provide insight whether there are key ages when dietary factors alter BC risk. This study brings together disparate areas of BC research (nutrition, epidemiology, changes in risks due to migration) in strategically selected populations with 3 fold difference in BC mortality in order to develop critical understanding of the nutritional risk factors and their implications in BC etiology. The research team has extensive experience in the conduct of epidemiological studies and unique access to these populations. The proposed study will examine the role of emerging and established risk factors for BC and their interactions. Thus, results from this study should help clarify the ambiguous findings for dietary fat, and will contribute to understanding the role specific vegetables and phytochemicals play in lowering BC risk, with clear implications for BC prevention.

波兰女性的乳腺癌发病率 (BC) 是其他女性的三分之一美国女性（1990 年每 10 万人中年龄调整后的比率；华沙市 37；华沙农村18；以及 1985 年 9 月；美国白人 94)。然而，最近对波兰语的研究西部移民的 BC 省移民死亡率与主办县的死亡率（标准化死亡率 91（美国）、100 （澳大利亚）和 97（英格兰和威尔士）。无其他流动人口已经表现出如此迅速的转变。表达这一点所需的时间很短 BC 风险的变化意味着可改变的环境因素风险的重要决定因素。为了评估这些因素的作用，出发地和目的地的特征、习惯的变化，以及这些变化发生的时间以及个人的特征必须评估影响 BC 风险的因素。我们建议进行两项平行的、基于人群的病例对照研究 20-74 岁的 BC 病例中有两个人群：1) 波兰出生居住在库克县的移民（378 例病例和 378 例对照）底特律大都市区和 2) 波兰裔，（500 例和 500 控制）居住在华沙市。我们假设日常饮食和过去饮食的成分是相关的有 BC 风险。我们假设在调整既定风险后 BC风险会增加的因素有： (1)减少特定物质的摄入食物类型（例如十字花科蔬菜、酸菜、根类蔬菜、全麦面包和其他谷物），因此：2）减少摄入量植物化学物质（例如芸苔素、类胡萝卜素、类黄酮和抗氧化剂）和膳食纤维； 3）增加肉类、肉类的摄入量产品和膳食脂肪； 4）饮食之间的相互作用上述1-3的成分。三点评估膳食摄入量生活中（1980年代末，初潮前，绝经前）将提供洞察力饮食因素是否会改变 BC 风险的关键年龄。这项研究汇集了 BC 研究的不同领域（营养、流行病学、移民导致的风险变化） BC 死亡率差异 3 倍的人群才能发展对营养风险因素及其影响的批判性理解对 BC 病因学的影响。研究团队经验丰富进行流行病学研究以及获得这些研究的独特途径人口。拟议的研究将探讨新兴和新兴市场的作用确定了 BC 的风险因素及其相互作用。因此，结果这项研究应该有助于澄清饮食中模棱两可的发现脂肪，并将有助于了解特定蔬菜和植物化学物质可降低 BC 风险，对 BC 具有明显影响预防。