DISCOVERY OF ANTIBODIES TO NEUROTRANSMITTER RECEPTORS

神经递质受体抗体的发现

• 批准号: 2501547
• 负责人: TIMOTHY STINCHCOMBE
• 金额: $ 10万
• 依托单位: TERA BIOTECHNOLOGY CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2501547
• 关键词: GABA receptor; antibody formation; antireceptor antibody; chemical structure function; ethanol; molecular cloning; neurotransmitter receptor; GABA receptor; antibody formation; antireceptor antibody; chemical structure function; ethanol; molecular cloning; neurotransmitter receptor

The contractor proposes to identify novel and useful antibodies using phage display cloning technology. Specifically, they propose to produce highly specific antibodies to individual subunits and epitopes on ethanol influenced neurotransmitter receptors that would be difficult, or impossible, to produce by typical hybridoma methodology. Their first target antigen in Phase I feasibility studies will be the gamma- aminobutyric acid receptor complex.

承包商建议使用 噬菌体展示克隆技术。 特别是，他们建议生产 对乙醇的单个亚基和表位的高度特异性抗体 影响很难的神经递质受体，或 不可能通过典型的杂交方法来产生。 他们的第一个 I期可行性研究中的靶抗原将是伽马 氨基丁酸受体复合物。