NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS

用于人类巴贝斯虫病血清学诊断的新抗原

• 批准号: 2422889
• 负责人: Raymond Houghton
• 金额: $ 9.99万
• 依托单位: CORIXA CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2422889
• 关键词: babesiosis; clinical research; diagnosis design /evaluation; human subject; protozoal antigen; recombinant proteins; serology /serodiagnosis

DESCRIPTION (Adapted from the Applicant's Abstract): This proposal discusses the production and implementation of peptide/recombinant antigens for the development of a serological assay for the diagnosis of human babesiosis, a tick-borne disease. Increased surveillance of tick borne infections has shown that many individuals infected with Lyme disease have co-infections with Babesia microti (agent of human babesiosis) and Ehrlichia both of which are potentially fatal in immunocompromised individuals any may impact blood transfusions. Since the treatment of B. microti infections (malaria-like intraerythrocytic parasite) is vastly different to Lyme disease there is a need for an accurate serology test to differentiate the two infections. B. microti specific peptides/recombinants will be used alone or in combination to develop an assay to supplement the currently available Lyme disease test. Development of specific antigens for B. microti for use in diagnosis improves our ability to detect tick-borne diseases and facilitates administration of the appropriate treatment. Advances have already been achieved at Corixa in identifying immunodominant recombinant antigens. This in combination with a collaboration with key investigator in the area of tick-borne diseases and access to an extensive serum bank accumulated through work on other infectious disease programs should enable the goals and objectives of this proposal to be achieved.

描述（改编自申请人的摘要）：本提案 讨论肽/重组蛋白的生产和实施 用于开发诊断血清学测定的抗原 人类巴贝斯虫病，一种蜱传疾病。加强蜱虫监测 传播性感染表明，许多人感染了莱姆病 该疾病与田鼠巴贝斯虫（人类病原体）同时感染 巴贝西虫病）和埃利希体，两者都可能致命 免疫功能低下的个体可能会影响输血。自从 治疗田鼠芽孢杆菌感染（疟疾样红细胞内感染） 寄生虫）与莱姆病有很大不同，因此需要一种 准确的血清学检测可区分两种感染。田鼠 特定的肽/重组体将单独或组合使用 开发一种检测方法来补充目前可用的莱姆病检测。 开发用于诊断的田鼠芽孢杆菌特异性抗原 提高我们检测蜱传疾病的能力并促进 给予适当的治疗。进展已经 Corixa 在识别免疫显性重组抗原方面取得了成就。 这与与主要研究人员的合作相结合 蜱传疾病领域和丰富的血清库 通过其他传染病规划工作积累的应 使本提案的目的和目标得以实现。