STEREOTACTIC BIOPSY OF BREAST LESIONS USING CCD IMAGING

使用 CCD 成像对乳腺病变进行立体定向活检

• 批准号: 2097072
• 负责人: Laurie L Fajardo
• 金额: $ 7.76万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2097072
• 关键词: biopsy; breast neoplasm /cancer diagnosis; breast neoplasms; clinical biomedical equipment; clinical trials; diagnosis quality /standard; digital imaging; female; fine needle aspiration; health care cost /financing; human subject; mammography; patient care management; phantom model

The proposed project will combine basic science imaging research with a prospective clinical trial to examine whether stereotactic breast needle biopsy (SBNB), guided by electronic Imaging, can be used to diagnose and manage patients with nonpalpable breast abnormalities. We have developed a digital stereotactic mammography system that uses a charge-coupled device (CCD) as the image receptor. This system generates high resolution digital breast images in 3-5 seconds, allowing the position of a biopsy needle to be rapidly verified. Thus, the accuracy and efficiency of performing percutaneous biopsy of nonpalpable breast lesions will be enhanced. The digital imaging system is now assembled and we currently are performing basic science experiments to assess the fundamental characteristics of the system, including modulation transfer function, signal to noise ratio, photon fluence, radiation dose and detective quantum efficiency. Next, the system will be used clinically to perform SBNB on 400 patients with nonpalpable breast lesions. Surgery will be performed only on those patients with a SBNB that is positive for cancer. Patients with negative SBNBs will be managed conservatively. and closely followed with mammography and physical examination every six months for two years. Any change in the lesion will prompt re-evaluation by needle or surgical biopsy. After two years of close follow-up, patients will return to routine breast cancer surveillance. Finally, we will evaluate the cost effectiveness of SBNB as a substitute for surgical breast biopsy in the evaluation and management of breast disease.

拟议的项目将把基础科学成像研究与 前瞻性临床试验检验立体定向乳腺针是否有效 电子成像引导下的活检（SBNB）可用于诊断和诊断 管理患有不可触及的乳房异常的患者。 我们开发了一个 使用电荷耦合装置的数字立体定向乳房X线摄影系统 （CCD）作为图像接收器。 该系统生成高分辨率数字 3-5 秒内获得乳房图像，从而可以确定活检针的位置 得到快速验证。因此，执行的准确性和效率 对不可触及的乳腺病变的经皮活检将得到加强。 数字成像系统现已组装完毕，目前正在执行 评估基本特征的基础科学实验 系统，包括调制传递函数、信噪比、 光子注量、辐射剂量和探测量子效率。 接下来， 系统将用于临床对400名患有此病的患者进行SBNB 无法触及的乳房病变。 手术将只对那些 SBNB 癌症呈阳性的患者。 阴性患者 SBNB 将采取保守管理方式。并密切关注乳房X光检查 两年内每六个月进行一次体检。 任何改变 病变将提示通过针刺或手术活检进行重新评估。 两点后 经过多年的密切随访，患者将恢复常规乳腺癌治疗 监视。 最后，我们将评估SBNB作为替代品的成本效益 用于外科乳腺活检以评估和管理乳腺 疾病。