ELECTROPHYSIOLOGY OF COGNITIVE DECLINE IN AGING AND DEMENTIA

衰老和痴呆症认知衰退的电生理学

• 批准号: 3726189
• 负责人: WALTER RITTER
• 金额: --
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3726189
• 关键词: aging; audiometry; auditory stimulus; biomarker; brain disorder diagnosis; brain electrical activity; brain mapping; cognition disorders; conditioning; dementia; electroencephalography; evoked potentials; human old age (65+); human subject; language disorders; longitudinal human study; magnetic resonance imaging; memory disorders; postmortem; sensorimotor system; space perception; visual stimulus; aging; audiometry; auditory stimulus; biomarker; brain disorder diagnosis; brain electrical activity; brain mapping; cognition disorders; conditioning; dementia; electroencephalography; evoked potentials; human old age (65+); human subject; language disorders; longitudinal human study; magnetic resonance imaging; memory disorders; postmortem; sensorimotor system; space perception; visual stimulus

The overall goal of this project is to combine longitudinal and cross sectional methodologies to identify markers of cognitive decline in normally aging and dementing individuals. In addition to the longitudinal data on changes in temporal and spatial aspects of event-related potentials (ERPs), specific experiments will assess cognitive operations that are vulnerable in the elderly and those at risk for dementia: semantic activation, elaboration at encoding on memory tasks, and motor slowing. Event-related potentials (ERPs) will be recorded from the scalp, time locked to auditory and visual stimuli. The ERP waveform is expected to vary as a function of experimental condition, age, and cognitive impairment, thus providing measures of the timing and efficiency of cognitive processing in three groups of the aged: normal, high risk for dementia, and demented. A detailed scalp topographic analysis, utilizing the Laplacian method for reference free measurements of transcranial current flow, will provide an indication of age-related change in the differential intracranial generation of these ERP components.

该项目的总体目标是结合纵向和交叉 鉴定认知能力下降的标记的分段方法 通常是老龄化和痴呆个体。 除了纵向 有关事件相关电位的时间和空间方面变化的数据 （ERP），具体实验将评估认知操作 老年人和有痴呆症风险的人易受伤害：语义 激活，在内存任务上进行编码时进行详细阐述以及电动机减速。 事件相关电位（ERP）将从头皮，时间记录 锁定在听觉和视觉刺激上。 ERP波形有望 随着实验条件，年龄和认知的函数而变化 损害，从而提供了定时和效率的措施 三组的认知处理：正常，高风险 痴呆，痴呆。 详细的头皮地形分析，利用 laplacian方法，用于参考无经颅的免费测量 当前流量将提供与年龄相关的变化的指示 这些ERP成分的颅内生成差异。