Development and validation of a smart harness to study babies with developmental dysplasia of the hip

开发和验证用于研究患有髋关节发育不良的婴儿的智能安全带

• 批准号: 10557616
• 负责人: Erin Mannen
• 金额: $ 19.26万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-06 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557616
• 关键词: 3-Dimensional; Agreement; Area; Avascular Necrosis of Femur Head; Biomechanics; Biometry; Birth; Caregivers; Centers of Research Excellence; Clinical; Clinical Research; Collection; Complication; Computer Analysis; Computer Models; Data; Data Collection; Data Reporting; Degenerative polyarthritis; Development; Devices; Disease; Dysplasia; Engineering; Equipment; Failure; Frequencies; Future; Goals; Hip Joint; Hip Osteoarthritis; Hip region structure; Home; Home environment; Hour; Human; Image; Industry Collaboration; Infant; Knowledge; Laboratories; Life; Manikins; Manuals; Measurement; Measures; Mechanics; Medical; Medical Device; Methods; Monitor; Motion; Movement; Operative Surgical Procedures; Outcome; Pain; Patient Self-Report; Population; Positioning Attribute; Recommendation; Research; Risk; Science; Shapes; Supination; Testing; Textiles; Time; Treatment Failure; Validation; Work; body position; cost; design; early onset; fabrication; femur head; flexibility; foot; human subject; improved; in vitro testing; in vivo; in vivo evaluation; manufacturing capabilities; pressure sensor; research study; sensor; success; tool

PROJECT SUMMARY – MANNEN Developmental dysplasia of the hip (DDH) is a mechanical disorder that impacts up to 10% of the population at birth, but given a lack of knowledge to inform research and treatment, can result in a lifetime of painful and costly biomechanical problems and osteoarthritis. Improving treatment depends on understanding how a baby interacts with the Pavlik harness mechanical therapy brace at home, yet no research tools exist that allow for such measurements. The purpose of this project is to develop and validate a “smart” harness to enable at home research relating to how babies being treated for DDH interact with the brace. We will (Aim 1) Develop sensors to measure biomechanics within the Pavlik harness, (Aim 2) Embed sensors onto the Pavlik harness and validate via in vitro testing, and (Aim 3) Validate the smart harness with in vivo human subjects testing. The smart harness developed in this study will provide a proof-of-concept research device on which we can design future research and clinical studies to monitor the wear time, body position, and kicking data of babies undergoing DDH treatment, resulting in a more thorough understanding of these modifiable factors on clinical success. This project fits within the overall COBRE theme by focusing on developing and embedding flexible sensors into a therapy device for biomedical applications. The Fabrication, Characterization, and Testing Research Core is critical to the success of this project. Specifically, I will use the advanced manufacturing capabilities and equipment to develop new flexible sensor types in Aim 1. The ElectroForce mechanical testing machine will be required to validate the kicking data from sensors in Aim 2. The 3D scanner will be required to develop computer models of the smart harness in Aim 3 and will be necessary for future computational analysis of the completed device.

项目摘要——曼南 发育性髋关节发育不良 (DDH) 是一种机械性疾病，影响多达 10% 的人口 出生，但由于缺乏研究和治疗方面的知识，可能会导致一生的痛苦和痛苦 昂贵的生物力学问题和骨关节炎的治疗取决于了解婴儿的情况。 与家里的 Pavlik 安全带机械治疗支架相互作用，但目前还没有研究工具允许 该项目的目的是开发和验证“智能”安全带，以实现 我们将（目标 1）开发有关接受 DDH 治疗的婴儿如何与支具相互作用的家庭研究。 用于测量 Pavlik 安全带内生物力学的传感器，（目标 2）将传感器嵌入到 Pavlik 安全带中 并通过体外测试进行验证，以及（目标 3）通过人体受试者体内测试验证智能安全带。 本研究中开发的智能安全带将提供一种概念验证研究设备，我们可以在该设备上 设计未来的研究和临床研究，监测婴儿的佩戴时间、身体姿势和踢腿数据 接受DDH治疗，从而更深入地了解这些可改变的因素对临床的影响 该项目注重开发和嵌入灵活性，符合 COBRE 的整体主题。 传感器到生物医学应用的治疗设备中的制造、表征和测试。 研究核心对于这个项目的成功至关重要，具体来说，我将使用先进制造。 目标 1 中开发新型灵活传感器的能力和设备。ElectroForce 机械测试 机器将需要验证目标 2 中传感器的踢球数据。3D 扫描仪将需要 开发 Aim 3 中智能安全带的计算机模型，这对于未来的计算是必要的 分析已完成的设备。