DISTRIBUTION OF MOUSE MODELS FOR NEURAL TUBE DEFECTS

神经管缺陷小鼠模型的分布

• 批准号: 2314482
• 负责人: MURIEL T DAVISSON
• 金额: $ 6万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2314482
• 关键词: DISTRIBUTION; MOUSE; MODELS; NEURAL; TUBE

Animal models are important experimental preparations for identifying the etiology of health problems in humans. The identification of animal models suitable for characterizing the underlying developmental biological mechanisms by which birth defects occur is especially important to the missions of the NICHD. Since malformations of the central nervous system are the most devastating developmental defects of man, the NICHD has focuse on the development of two animal models for neural tube defects. Two mouse models for neural tube defects (NTD), the TCu/tct and the curly tail were developed under contracts N01-HD-6-2925 and N01-HD-6-2926. The specific objective of this contract is to maintain and distribute the two mutant strains of mice which were developed under NICHD support. The contractor is to maintain breeding stocks of the genetically defined strains, ct/ct, TCu/TCu, tct/tct, in a healthy condition with 20 breeding paris of mutant animals available for distribution at all times. The animals are to be distributed to investigators at $21 per pair. The contractor will maintain complete breeding records on all the animals, and embryos will be frozen in order to ensure that stocks are not lost. In order to ensure that the scientific community is aware of this service, the contractor will institute a program to publicize the availability of these mutant models by advertizing them in the Jackson Laboratory catalogue, by placing advertisements in journals and by presenting data at scientific meetings.

动物模型是识别的重要实验制剂 人类健康问题的病因。 动物模型的识别 适合表征潜在的发展生物学 出生缺陷的机制对 NICHD的任务。 由于中枢神经系统的畸形 NICHD是人类最具破坏性的发展缺陷， 关于神经管缺陷的两个动物模型的开发。 两只鼠标 神经管缺陷（NTD），TCU/TCT和卷曲尾巴的模型是 根据合同N01-HD-6-2925和N01-HD-6-2926开发。 该合同的具体目标是维护和分发 在NICHD支持下开发的两种突变菌株。 这 承包商应维持遗传定义的繁殖库存 菌株，CT/CT，TCU/TCU，TCT/TCT，具有20种繁殖状态 突变动物的巴黎始终可分发。 这 动物应以每双21美元的价格分配给研究人员。 这 承包商将在所有动物上保持完整的育种记录，并保持 胚胎将被冻结，以确保股票不会丢失。 在 为了确保科学界知道这项服务， 承包商将制定一项计划，以宣传这些计划 突变模型通过在杰克逊实验室目录中宣传它们， 将广告放置在期刊中，并通过在科学上展示数据 会议。