MED CORD CENTER FOR VIRAL ACTIVATION TRANSFUSION STUDY

病毒激活输血研究 MED CORD 中心

• 批准号: 2312791
• 负责人: Leslie Kalish
• 金额: $ 33.55万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2312791
• 关键词: MED; CORD; CENTER; VIRAL; ACTIVATION

The contractor shall serve as the Medical Coordinating Center for the Viral Activation Transfusion Study. This study is designed to determine if transfusion is followed by activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affects prognosis. It will also evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion.

承包商应作为医疗协调中心 病毒激活输血研究。 这项研究旨在确定 如果输血之后激活HIV-1和巨细胞病毒 （CMV）在HIV-1感染的人中，从而对预后产生不利影响。 它还将评估产生此的供体白细胞的作用 通过检查通过过滤去除白细胞的效果来激活 废除了他们通过伽马辐射增殖的能力。 最后， 该研究将检查供体淋巴细胞的持续性 输血。