Mechanisms linking dietary fiber, the microbiome, and satiety

膳食纤维、微生物组和饱腹感之间的联系机制

基本信息

批准号：
10546471
负责人：
Katherene O Anguah
金额：
$ 14万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-15 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10546471
关键词：
Acetates Acids Adult Animals Appetite Regulation Bacteroidetes Bifidobacterium Biological Blood Blood Glucose Blood Pressure Brain Brain region Butyrates Carbohydrates Cardiometabolic Disease Cardiovascular Diseases Chronic Clinical Colon Colonoscopy Consumption Cues Data Data Analyses Desire for food Development Diabetes Mellitus Diet Dietary Carbohydrates Dietary Component Dietary Fiber Dietary Practices Eating Fabaceae Feeling Fermentation Fiber Firmicutes Firmicutes Bacteroidetes ratio Food Functional Magnetic Resonance Imaging Future GCG gene Gastrointestinal Hormones Glucose Goals Health Heart Diseases Hormones Human Hypertension Infusion Technique Instruction Intake Intervention Intervention Studies Intestinal Hormones Intestinal Secretions Intestines Lead Link Malignant Neoplasms Mass Spectrum Analysis Measures Mediating Mediator Mentors Metabolic Metabolic syndrome Metabolism Methods Microbe Non-Insulin-Dependent Diabetes Mellitus Nuts Outcome Paper Peptide YY Persons Pisum sativum Play Population Production Propionates Randomized, Controlled Trials Recommendation Research Rewards Risk Risk Factors Rodent Role Satiation Seminal Signal Transduction Stable Isotope Labeling Standardization Testing Training Triglycerides Upper digestive tract structure Vegetables Visual Volatile Fatty Acids Weight Weight Gain Woman Work Writing absorption blood glucose regulation blood lipid cardiometabolic risk cardiometabolism career career development design dietary executive function experience feeding gastrointestinal glucagon-like peptide 1 gut microbes gut microbiome heart disease risk improved men metabolomics microbial microbial composition microbiome microbiome analysis nutrient absorption obesity risk programs reduced food intake response screening skill acquisition skills stable isotope translational scientist waist circumference

项目摘要

PROJECT SUMMARY/ABSTRACT This project supports the career development of Dr. Katherene Anguah in her path to become an independent translational researcher focusing on how dietary components may benefit cardiometabolic health through the control of appetite. The mentored plan builds on previous training by providing additional technical, academic, and professional development skills to facilitate research independence. An interdisciplinary team of mentors includes experts in human clinical feeding studies, functional magnetic resonance imaging, microbiome analysis, and stable isotope labeled, targeted metabolomics. The 5-year plan includes the opportunity to advance through both didactic instruction and experiences aimed at expanding skills in research management and scientific writing. Rationale: Strong evidence supports the association between high fiber (HiFi) diets (e.g. legumes, nuts, vegetables) and a reduced risk for chronic conditions such as cardiovascular disease (CVD), type 2 diabetes and some forms of cancer. However, the current U.S. average consumption of dietary fiber of 17g/day is significantly below the recommendation level of 25g/d for women and 38g/d for men. Furthermore, fiber fermentation to produce short chain fatty acid (SCFA) products and alterations in microbial composition and activity may be mechanisms linking a HiFi diet to improved health. Importantly, much of the data, including findings supporting a beneficial role of SCFA have been derived from animal studies. Human studies are now needed to advance the understanding of the translational significance of rodent studies and the potential benefit of fiber on microbial metabolites and cardiometabolic health, glucose regulation, appetite and satiety. The central hypothesis is that that the mechanisms by which dietary fiber provides metabolic benefit include direct physical effects in the upper gastrointestinal tract to slow nutrient absorption, and indirect effects to reduce food intake mediated by SCFA-induced secretion of intestinal hormones resulting in increased satiety. Design: Using fiber derived from peas, Aim 1 will test the effect of a HiFi diet on appetite, satiety, and cardiometabolic health and whether elevated SCFA concentration mediates improved satiety. Aim 2 will quantitate the changes in microbial composition and colonic SCFA production rate during HiFi feeding and whether any changes are potential mediators of observed benefits on satiety and cardiometabolic risk factors. Relevance: These studies will significantly expand the understanding of mechanisms by which dietary fiber improves satiety and cardiometabolic health in humans.

项目概要/摘要该项目支持 Katherene Anguah 博士的职业发展，帮助她成为一名独立转化研究人员，专注于饮食成分如何有益于心脏代谢健康是通过控制食欲来实现的。该指导计划以之前的培训为基础，提供了额外的技术、学术和专业发展技能，以促进研究独立性。一个跨学科导师团队包括人类临床喂养研究、功能磁力研究方面的专家共振成像、微生物组分析和稳定同位素标记的靶向代谢组学。 5年期计划包括通过教学指导和经验来推进的机会扩大研究管理和科学写作的技能。理由：强有力的证据支持高纤维 (HiFi) 饮食（例如豆类、坚果、蔬菜）与降低慢性病风险之间的关联心血管疾病 (CVD)、2 型糖尿病和某些癌症等疾病。然而，目前美国膳食纤维的平均摄入量为 17 克/天，明显低于推荐值女性每日 25 克，男性每日 38 克。此外，纤维发酵产生短链脂肪酸（SCFA）产物以及微生物组成和活性的改变可能是联系 HiFi 饮食可改善健康。重要的是，许多数据，包括支持有益作用的发现 SCFA 源自动物研究。现在需要进行人体研究来推进了解啮齿动物研究的转化意义以及纤维的潜在益处微生物代谢物和心脏代谢健康、葡萄糖调节、食欲和饱腹感。中央假设是膳食纤维提供代谢益处的机制包括直接上胃肠道的物理作用会减缓营养吸收，间接作用会减少 SCFA 诱导肠道激素分泌介导的食物摄入，导致饱腹感增加。设计：Aim 1 使用源自豌豆的纤维来测试 HiFi 饮食对食欲、饱腹感和食欲的影响。心脏代谢健康以及 SCFA 浓度升高是否会改善饱腹感。目标2将定量 HiFi 喂养期间微生物组成和结肠 SCFA 生产率的变化任何变化是否是观察到的饱腹感和心脏代谢风险益处的潜在中介因素因素。相关性：这些研究将显着扩大对机制的理解膳食纤维可以改善人类的饱腹感和心脏代谢健康。