CHEMISTRY SUPPORT SERVICES FOR NTP

NTP 化学支持服务

• 批准号: 2308252
• 负责人: EVELYN A MURRILL
• 金额: $ 26万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-10 至 1995-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308252
• 关键词: CHEMISTRY; SUPPORT; SERVICES; NTP; CHEMISTRY; SUPPORT; SERVICES; NTP

This project plan is for the supplemental support of chemistry activities of the toxicology contractors as well as to provide chemistry support for the staff research activities of the Chemical Carcinogenesis Branch. The resources of the chemistry support contractor will be used to: 1) procure difficult to obtain test chemicals prior to issuance of a Request For Proposals to ensure that a toxicology study can be conducted; 2) provide special handling of the bulk chemicals such as purification or particle size reduction that may be needed prior to use in dose formulations; 3) identify low level impurities that may have an impact on the evaluation of the carcinogenesis study results; 4) generate information for some test chemicals to assist in study design such as stability in the proposed dose vehicle or the maximum concentration in the vehicle that can be achieved; 5) evaluate and resolve analytical problems encountered by the toxicology contractors and 6) provide chemistry support for in-house studies including analysis of test article or metabolites in tissues or biological fluids.

该项目计划是为了补充化学活动的补充支持 毒理学承包商以及为化学支持提供 化学癌变分支的员工研究活动。 这 化学支持承包商的资源将用于：1）采购 在发布请求之前很难获得测试化学物质 提案以确保可以进行毒理学研究； 2）提供 特殊处理批量化学物质（例如纯化或颗粒） 在剂量配方中使用之前可能需要的尺寸降低； 3） 确定可能影响评估的低级杂质 致癌研究结果； 4）生成一些测试的信息 辅助研究设计的化学品，例如拟议剂量的稳定性 可以实现的车辆或最大浓度； 5）评估和解决毒理学遇到的分析问题 承包商和6）为内部研究提供化学支持，包括 分析组织或生物液中的测试文章或代谢产物。