Brain Rehabilitation Research Center

脑康复研究中心

基本信息

批准号：
10534109
负责人：
PRODIP K. BOSE
金额：
--
依托单位：
VETERANS HEALTH ADMINISTRATION
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-10-01 至 2024-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10534109
关键词：
Achievement Affect Age Animal Model Attention Award Benchmarking Biological Markers Brain Brain imaging Budgets Caring Chronic Clinical Cognition Cognitive Collaborations Diagnosis Disease Emotional Emotions Equipment Ethnic Origin Etiology Feedback Florida Fright Funding Gait Gender Goals Health Health system Healthcare Healthcare Systems Hospitals Human Impaired cognition Inflammatory Institution Interdisciplinary Study Intervention Leadership Locomotor training Long-Term Care Measurement Measures Memory Memory impairment Mentors Mission Motor Nervous System Trauma Neurodegenerative Disorders Neurologic Neuronal Plasticity Neurosciences Organizational Models Pathologic Pathology Performance Personal Satisfaction Post-Traumatic Stress Disorders Process Protocols documentation Psychotherapy Quality of life Race Recovery Regimen Rehabilitation therapy Research Research Personnel Resource Sharing Resources Rodent Model Role Science Self Efficacy Services Strategic Planning Stroke Structure Survivors Testing Time Training Traumatic Brain Injury Universities Upper Extremity Upper limb movement Veterans Walking career central nervous system injury chronic stroke clinical practice clinical translation cognitive recovery comorbidity comparative effectiveness trial cost cost effective cost estimate disability efficacy evaluation emotion regulation executive function falls feasibility testing functional restoration gait rehabilitation genetic variant human model improved innovation motor recovery multiple disability nervous system disorder neural neural network neurological rehabilitation neurophysiology novel persistent symptom post stroke pre-clinical program dissemination programs rehabilitation research response sensory feedback stroke intervention stroke survivor stroke therapy

项目摘要

The Mission of the Brain Rehabilitation Research Center (BRRC) is: Maximize recovery of cognitive, emotion, and motor function in Veterans affected by neurologic injury or disease by potentiating neural plasticity and neural network reorganization through the discovery of mechanisms and innovation of treatments. The BRRC is a 19-yr consortium with three major institutions: North Florida/South Georgia VA Health Care System, University of Florida (UF)/Shands Healthcare, and Brooks Rehabilitation Hospital. The BRRC supports > 28 investigators (14 PIs with VA-funded studies, 14 associate investigators, and additional collaborating investigators) and their teams. The BRRC supports a collaborative, interdisciplinary research team, providing extensive facilities and resources for sophisticated human performance and brain function measurement. Our planned research programs utilize specific neuroplastic mechanisms to recover cognitive, emotion, and motor function. First, in the Cognition Function Initiative, we are developing innovative treatment for impaired memory, executive function, and goal achievement in TBI survivors. Second, in the Emotion Function Initiative, we are establishing new brain neuromarkers for objective diagnosis of PTSD and prediction of psychotherapy response in the presence and absence of TBI. We are investigating the etiological, pathological and neurophysiological mechanisms of PTSD comorbid with TBI, identifying brain networks involved in the emotional consequences of PTSD/TBI, and testing novel interventions to aid in recovery of emotion regulation. Third, in the Motor Function Initiative, we are investigating brain activation mechanisms during walking and during upper limb movement, to elucidate pathology and identify more useful treatment targets for inducing motor recovery. We are developing and feasibility-testing a new brain neural feedback regimen (real time brain imaging) to improve upper limb function after stroke. We are testing several innovative gait training interventions for stroke survivors: combination of gait coordination and brain stimulation; backward walking training paradigm; enhancing sensory feedback during walking and testing emotional fear factors related to fall self-efficacy; and feasibility-testing a protocol for a comparative effectiveness trial, for long-term mobility and health for chronic stroke. Fourth, in the Rehabilitation Neuroscience Initiative (animal and human models), we are refining our preclinical rodent models of TBI and SCI that reflect clinical symptoms of chronic and persistent disabilities in human TBI/SCI. We are establishing reliable, quantitative, and clinically translatable measures for assessing chronic multiple disabilities and for illuminating the role of TBI in chronic human neurodegenerative disease. We are evaluating efficacy of combined interventions, such as locomotor training and CNS stimulation, to mitigate TBI-induced disabilities. In stroke and TBI separately, we are evaluating the impact of potential modifiers such as age, gender, race/ethnicity, and moderating biomarkers of gene variants, brain structure/function, and inflammatory processes on cognitive impairment. The BRRC has consistently achieved the benchmarks expected by the RR&D Service, as follows: * Thematically cohesive, neural plasticity research portfolio focused on RR&D high priority Veteran needs for those with neurological injury or disease. * Robust science dissemination program, including national leadership by BRRC investigators. * Active and successful capacity-building program, including support and mentoring across career stages. * Excellent funding leverage ratio of Core Center award. * Acquisition and stewardship of extensive facilities, equipment, and shared resources for investigators. * Successful organizational model with a track record of strongly supporting investigators, inclusive budget planning process, visionary strategic planning process.

脑康复研究中心（BRRC）的使命是：最大限度地恢复受神经损伤或影响的退伍军人的认知、情感和运动功能通过增强神经可塑性和神经网络重组来治疗疾病机制和治疗创新。 BRRC 是一个拥有 19 年历史的联盟，由三个主要机构组成：北佛罗里达州/南乔治亚州 VA 医疗保健机构 System、佛罗里达大学 (UF)/Shands Healthcare 和布鲁克斯康复医院。商业研究委员会支持超过 28 名研究人员（14 名 PI 参与 VA 资助的研究，14 名副研究人员，以及其他合作研究人员）及其团队。 BRRC 支持协作、跨学科研究团队，为复杂的人类表现和大脑功能提供广泛的设施和资源测量。我们计划的研究项目利用特定的神经可塑性机制来恢复认知、情绪和运动功能。首先，在认知功能计划中，我们正在开发创新的治疗方法治疗 TBI 幸存者的记忆力、执行功能和目标实现受损。二、在情感上 Function Initiative，我们正在建立新的大脑神经标志物，用于客观诊断 PTSD 和预测存在和不存在 TBI 时的心理治疗反应。我们正在调查病因， PTSD 与 TBI 共病的病理和神经生理学机制，识别大脑网络参与 PTSD/TBI 的情绪后果，并测试新的干预措施以帮助恢复情绪调节。第三，在运动功能计划中，我们正在研究大脑激活机制在行走和上肢运动期间，阐明病理学并确定更有用的治疗方法诱导运动恢复的目标。我们正在开发并测试一种新的大脑神经反馈改善中风后上肢功能的方案（实时脑成像）。我们正在测试几个针对中风幸存者的创新步态训练干预措施：步态协调与大脑刺激相结合；倒走训练范例；增强行走过程中的感官反馈并测试情绪恐惧与跌倒自我效能相关的因素；以及可行性测试比较有效性试验的方案，慢性中风的长期活动能力和健康。第四，在康复神经科学倡议（动物和人类模型），我们正在完善反映临床症状的 TBI 和 SCI 临床前啮齿动物模型人类 TBI/SCI 中慢性和持续性残疾的研究。我们正在建立可靠的、定量的、临床的用于评估慢性多重残疾和阐明 TBI 在慢性多重残疾中的作用的可转化措施人类神经退行性疾病。我们正在评估联合干预措施的效果，例如运动训练和中枢神经系统刺激，以减轻 TBI 引起的残疾。分别在中风和 TBI 方面，我们评估潜在修饰因素的影响，例如年龄、性别、种族/民族以及调节生物标志物基因变异、大脑结构/功能和认知障碍的炎症过程。 BRRC 始终达到 RR&D 服务预期的基准，如下： * 主题有凝聚力的神经可塑性研究组合，重点关注 RR&D 退伍军人的高优先级需求患有神经损伤或疾病的人。 * 强有力的科学传播计划，包括由 BRRC 调查人员领导的国家计划。 * 积极且成功的能力建设计划，包括跨职业阶段的支持和指导。 * 核心中心奖优秀的资金杠杆率。 * 为调查人员获取和管理大量设施、设备和共享资源。 * 成功的组织模式，具有大力支持调查人员的记录，包容性预算规划过程，有远见的战略规划过程。