Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive Disorder

强迫症功能神经影像以患者为导向的研究、指导和培训

基本信息

批准号：
10535440
负责人：
Christopher John Pittenger
金额：
$ 17.93万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10535440
关键词：
Achievement Adult Area Award Brain Clinic Clinical Code Collaborations Data Data Analyses Dedications Department chair Disease Dissociation Doctor of Philosophy Double-Blind Method Drug Exposure Educational process of instructing Faculty Feedback Fluoxetine Fostering Functional Magnetic Resonance Imaging Functional disorder Funding Future Generations Gilles de la Tourette syndrome Goals Grant Health Sciences High School Student Human Image Imaging technology Individual Infrastructure K-Series Research Career Programs Lead Leadership Linux Machine Learning Mentors Mentorship Motivation National Institute of Mental Health Neurobiology Neurosciences Neurosciences Research Obsessive-Compulsive Disorder Pharmaceutical Preparations Pharmacotherapy Physicians Positioning Attribute Postdoctoral Fellow Preceptorship Prediction of Response to Therapy Protocols documentation Psychiatry Publishing Pythons Research Research Ethics Research Personnel Research Project Grants Residencies Rest Scanning Scientist Services Statistical Methods Structure Students Time Training Training Activity Training Programs Training Support Translational Research Universities Work career career development connectome design disorder control experimental study graph theory improved innovation insight mid-career faculty neurofeedback neuroimaging next generation novel patient oriented patient oriented research predicting response programs research study simulation skills statistics success symptomatic improvement symptomatology teacher

项目摘要

ABSTRACT This K24 Mid-Career Investigator Career Development Award seeks support for training and mentorship for Christopher Pittenger, MD, Ph.D., a well-established, tenured Associate Professor in Psychiatry at Yale University, Director of the Yale OCD Research Clinic, and Assistant Chair for Translational Research in the Department of Psychiatry. Dr. Pittenger leads a robust patient-oriented research (POR) research program, which is integrated with his basic/translational lab-based research and has produced important new insights into the neurobiological underpinnings and novel treatment avenues for obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). Dr. Pittenger has a long-standing commitment to mentorship; most notably, he is Co-Director of the Neuroscience Research Training Program (NRTP), the research track within the Yale psychiatry residency. The training plan supported by this grant will allow Dr. Pittenger to increase his skills in quantitative analysis, with a focus on advanced statistical methods and on the design and analysis of fMRI studies. These are areas in which he already has active research with expert collaborators; the aim of the proposed training plan is to enhance his own proficiency to make him a more effective collaborator and mentor in these important domains. Additional training is focused on his own abilities as a mentor and leader, with the goal of increasing his efficacy in the management of his own research groups and in effective and individualized mentorship. These training activities will take place in the context of two NIMH- funded research studies. The first, R01 MH116038, is a recently funded grant on which Dr. Pittenger is co-PI with his close collaborator Alan Anticevic and deploys cutting-edge imaging technology and data analysis approaches to examine brain network connectivity parallels and predictors of therapeutic response to pharmacotherapy in OCD. The second, R01 MH100068, is a grant with collaborator Michelle Hampson that is developing real-time fMRI neurofeedback as a probe and potential treatment for OCD, with promising early results. These two exciting projects provide a fruitful vehicle for the proposed training in statistics and neuroimaging. Dr. Pittenger will devote substantial time to mentoring under this award. One major focus will be the NRTP; the plan is for him to take over as Director of this program over the next few years, and to take the lead in the next resubmission of our T32 grant in 2022. Support of this increased mentorship effort is a second major motivation for the current application. Dr. Pittenger will also provide mentorship to students, postdocs, and junior faculty in his own research program and throughout the Department of Psychiatry Together, these integrated plans for training, research, and mentorship will support a well-established mid-career investigator whose robust research program is producing important insights into the neurobiology and treatment of OCD and TS, and whose dedicated mentorship efforts are helping to establish a new generation of translationally grounded patient-oriented researchers in psychiatric neuroscience.

抽象的该 K24 职业生涯中期研究者职业发展奖寻求对以下人员的培训和指导的支持： Christopher Pittenger，医学博士、博士，耶鲁大学精神病学终身副教授、主任耶鲁大学强迫症研究诊所院长，精神病学系转化研究助理主任。博士。 Pittenger 领导了一个强大的以患者为导向的研究 (POR) 研究项目，该项目与他的基础/转化实验室研究，并对神经生物学基础产生了重要的新见解以及强迫症（OCD）和抽动秽语综合症（TS）的新治疗途径。皮滕格博士有一个长期致力于指导；最值得注意的是，他是神经科学研究培训的联合主任项目（NRTP），耶鲁大学精神病学住院医师培训的研究方向。这笔赠款支持的培训计划将使 Pittenger 博士能够提高定量分析技能，专注于先进的统计方法以及功能磁共振成像研究的设计和分析。这些都是他已经涉足的领域与专家合作者积极进行研究；拟议培训计划的目的是提高他自己的能力使他在这些重要领域成为更有效的合作者和导师。额外的训练集中在他的自己作为导师和领导者的能力，目标是提高自己研究管理的效率团体以及有效和个性化的指导。这些培训活动将在两个 NIMH- 资助的研究。第一个项目是 R01 MH116038，是最近资助的一项赠款，Pittenger 博士与他的亲密伙伴共同担任该赠款的共同负责人。合作者 Alan Anticevic 部署尖端成像技术和数据分析方法来检查大脑强迫症药物治疗的网络连接相似性和治疗反应的预测因素。第二个，R01 MH100068 是与合作者 Michelle Hampson 的一项资助，该项目正在开发实时功能磁共振成像神经反馈作为探针以及强迫症的潜在治疗方法，并取得了有希望的早期结果。这两个激动人心的项目为拟议的统计和神经影像培训。 Pittenger 博士将投入大量时间来获得该奖项的指导。其中一个主要焦点是 NRTP；计划是让他在未来几年里接任这个项目的主任，并在下次重新提交中带头 2022 年我们的 T32 赠款。支持这种增加的指导工作是当前的第二个主要动机应用。皮滕格博士还将在他自己的研究中为学生、博士后和初级教师提供指导计划和整个精神病学系这些培训、研究和指导的综合计划将共同支持完善的中期职业生涯研究员，其强大的研究计划正在对神经生物学和强迫症治疗产生重要见解和 TS，他们的专注指导工作正在帮助建立新一代的翻译基础精神神经科学领域以患者为中心的研究人员。