Signal Processing Along the Auditory Pathway: Changes Following Noise Exposure

沿着听觉通路的信号处理：噪声暴露后的变化

• 批准号: 10536262
• 负责人: Wei Dong
• 金额: --
• 依托单位: VA LOMA LINDA HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536262
• 关键词: Affect; American; Animals; Apical; Auditory; Auditory Threshold; Auditory system; Back; Brain; Calibration; Cessation of life; Clinic; Clinical; Cochlea; Complex; Coupling; Diagnosis; Diagnostic; Diagnostic tests; Differential Diagnosis; Ear; Elements; Environment; External auditory canal; Foundations; Frequencies; Gerbils; Goals; Hair Cells; Health; Hearing; Hearing Tests; Human; Impairment; Individual; Injury; Intervention; Knowledge; Labyrinth; Link; Loudness; Maps; Measurement; Measures; Mechanics; Medical; Military Personnel; Modeling; Monitor; Motion; Nervous System; Neurons; Noise; Optical Coherence Tomography; Outer Hair Cells; Physiological; Population; Rehabilitation therapy; Research; Sensorineural Hearing Loss; Sensory; Services; Signal Transduction; Speech; Speech Perception; Structure; Structure-Activity Relationship; System; Techniques; Testing; Time; Translating; Traumatic Brain Injury; Veterans; Work; auditory pathway; blast exposure; cell injury; clinical application; clinical diagnosis; design; diagnostic tool; experimental study; hearing impairment; improved; individual response; neural; neural hearing loss; noise exposure; normal hearing; notch protein; novel; otoacoustic emission; personalized diagnostics; rehabilitation strategy; response; signal processing; sound

Project Summary/Abstract Sensorineural hearing loss (SNHL) in military personnel is commonly caused by noise- or blast-related damage to the auditory periphery (cochlea) and/or the central system, which includes changes in the integrity of the cochlear partition and cellular death along the auditory pathway. Hearing loss is often permanent, and there exist no cures for sustained injuries. The current proposal seeks to characterize the signal processing along the auditory pathway by establishing the structure-function relationship in both normal ears and with various types of SNHL. The overall goal is to improve the diagnosis of SNHL within the clinic by separating contributions from cochlear (sensory) and retro-cochlear (neural) loss. We will combine a novel, state-of-the-art measurement technique (optical coherence tomography, OCT) with recordings that are already available in the clinic [i.e., distortion product otoacoustic emissions (DPOAE) in the ear canal and frequency-following responses (FFR) from the cortex] so that the cochlear mechanics and the detrimental effects of noise- or blast- exposure can be evaluated at different stages along the auditory pathway. As of now, OCT measures from the cochlea cannot be recorded from humans, but we expect that the combination of DPOAE and FFR provides a differential diagnosis of SNHL that distinguishes damage of the sensory versus neural component. Aim 1 of this proposal will form the foundation of the study by determining how DPOAEs and FFRs relate to cochlear micromechanics in normal gerbil ears. The experimental results will be used to develop a Best Approximation Model (BAM) that will predict cochlear function using DPOAEs and FFRs. In Aim 2 we will explore how various forms of SNHL change the underlying cochlear mechanics with the specific design to differentially diagnose sensory and neural hearing loss and establish how these changes can be quantified using a combination of DPOAE and FFR measurements. These results will further validate the BAM developed under Aim 1. In Aim 3 we will apply the knowledge obtained in animals to humans that suffer from different types of SNHL to improve the clinical differential diagnosis of an SNHL using DPOAEs, FFRs, and the BAM. Using direct and simultaneous measurements along the auditory pathway, the signal processing under these conditions will be quantified in detail. The proposed research will advance our understanding of sound processing within the auditory system, especially at low frequencies that are important for speech and provide critical information to improve our ability to diagnose and develop new treatments for SNHL. This will benefit our Veterans, many of whom suffer from noise/blast-induced hearing loss.

项目概要/摘要 军事人员的感音神经性听力损失 (SNHL) 通常是由噪音或爆炸相关引起的 听觉外围（耳蜗）和/或中枢系统受损，包括完整性改变 耳蜗分隔和听觉通路上的细胞死亡。听力损失通常是永久性的，并且 持续性损伤无法治愈。当前的提案旨在描述信号处理的特征 通过建立正常耳朵和正常耳朵的结构-功能关系，沿着听觉通路 各种类型的 SNHL。总体目标是通过分离来改善临床中 SNHL 的诊断 耳蜗（感觉）和耳蜗后（神经）损失的贡献。我们将结合新颖的、最先进的 测量技术（光学相干断层扫描，OCT），其记录已在 临床[即耳道中的失真产物耳声发射（DPOAE）和频率跟踪 来自皮质的反应（FFR）]以便耳蜗力学和噪音或爆炸的有害影响 暴露可以在听觉通路的不同阶段进行评估。截至目前，OCT 措施 无法记录人类的耳蜗，但我们期望 DPOAE 和 FFR 的结合提供 SNHL 的鉴别诊断，区分感觉和神经部分的损伤。目标 1 的 该提案将通过确定 DPOAE 和 FFR 与人工耳蜗的关系来构成研究的基础 正常沙鼠耳朵的微观力学。实验结果将用于开发最佳近似值 使用 DPOAE 和 FFR 预测耳蜗功能的模型 (BAM)。在目标 2 中，我们将探讨不同的 SNHL 的形式通过特定设计改变了潜在的耳蜗力学以进行鉴别诊断 感觉和神经听力损失，并确定如何使用组合来量化这些变化 DPOAE 和 FFR 测量。这些结果将进一步验证目标 1 下开发的 BAM。 在目标 3 中 我们将从动物身上获得的知识应用于患有不同类型 SNHL 的人类，以改善 使用 DPOAE、FFR 和 BAM 对 SNHL 进行临床鉴别诊断。使用直接和 沿着听觉通路同时测量，这些条件下的信号处理将是 详细量化。拟议的研究将增进我们对声音处理的理解 听觉系统，特别是在低频下，这对于言语很重要，并为人提供关键信息 提高我们诊断和开发 SNHL 新疗法的能力。这将使我们的退伍军人受益，其中许多人 患有噪音/爆炸引起的听力损失的人。