Multi-site Data for Nutrition Studies in Healthy Early Childhood

健康幼儿营养研究的多站点数据

基本信息

批准号：
10528096
负责人：
Yangming Ou
金额：
$ 8.85万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-04 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10528096
关键词：
Adult Affect Archives Area Behavior Birth Boston Brain Brain imaging Breast Feeding Carotenoids Child Child Health Childhood Clinical Trials Combinatorics Data Data Set Dementia Demographic Factors Development Diet Dietary intake Diffusion Elderly Environment Feeding Patterns Food Frequencies Functional Magnetic Resonance Imaging Funding Goals Grant Health Hour Human Development Human Milk Infant Lactation Letters Life Life Style Link Magnetic Resonance Imaging Manuals Metadata Milk Mothers Motor National Institute of Child Health and Human Development Neurocognition Neurocognitive Newborn Infant Nutrient Outcome Parents Participant Patient Self-Report Pediatric Hospitals Pigments Population Premature Infant Process Questionnaires Recommendation Research Personnel Rest Sampling School-Age Population Site Socioeconomic Status Structure Testing United States National Institutes of Health Visit Woman autism spectrum disorder brain health brain magnetic resonance imaging cohort combat data dictionary data structure demographics density diaries dietary early childhood follow-up high risk infant improved infancy macula morphometry mother nutrition neonatal brain nutrition offspring precision nutrition prospective recruit secondary analysis symposium user-friendly

项目摘要

Project Summary/Abstract This project aims to release our recently gathered unique data for nutrition studies of healthy term-born infants through school age. Brain development is a major health domain, and infancy is a period when the brain develops most rapidly and is perhaps most vulnerable to the lack of nutrition. Studies on nutrition’s effect on brain health are mostly on the elderly especially dementia populations. Very few studies on nutrition’s effect on brain healthy are on infants, but mostly on infants born pre-term, who clearly need nutrition supplements but only account for ~10% of all newborns. Term-born healthy infants constitute ~90% of newborns, and they pose specific requirement for nutrition, but are rarely studied. In 2014-2018 (clinical trial NCT02058225), we have acquired comprehensive data to study how maternal dietary intake of nutrition impacts healthy term-born infants’ brain health during the first 3 months after birth. In 2019-2020, we have additionally collected neurocognitive outcome questionnaires now that those children are in early school age. Overall, our data were collected in two large women’s and children’s hospitals for 145 healthy mother-infant dyads. Our data include: (1) demographics of parents and infants; (2) food frequency questionnaires (FFQ) of maternal dietary intake of nutrition during lactation, which were already converted into 73 nutrients; (3) milk feeding patterns (breastmilk- or formula, or a combination); (4) socioeconomic status and lifestyle questionnaires from the parents; (5) breastmilk nutrition components; (6) maternal macular pigment ocular density (MPOD), which is an easy-to-obtain, quantitative reflection of specific maternal nutrition in carotenoids; (7) infant brain MRI (structural, diffusion, functional) at 1 and 3-month of life after birth; (8) infant Mullen score reflecting neurocognitive functions at 3 months (e.g., motor); and (9) neurocognitive questionnaires and the converted neurocognitive scores at early school age (4-6 years). We propose to organize the data (Aim 1), process and harmonize multi-site MRI (Aim 2), and publicly-release this otherwise rarely-available comprehensive data (Aim 3). This data can help study how dietary and breastmilk nutrition are related to early-infancy brain structure and function, how they correlate with school-age neurocognition, and how they interact with socioeconomic status and demographic factors.

项目概要/摘要该项目旨在发布我们最近收集的健康足月婴儿营养研究的独特数据整个学龄期的大脑发育是一个主要的健康领域，而婴儿期是大脑发育的时期。关于营养对大脑健康影响的研究最快，也可能最容易受到营养缺乏的影响。主要针对老年人，尤其是痴呆症人群，很少有关于营养对大脑健康影响的研究。是针对婴儿，但主要针对早产儿，他们显然需要营养补充，但只占足月出生的健康婴儿占所有新生儿的约 10%，占新生儿的约 90%，他们具有特定的特征。营养需求，但很少研究在2014-2018年（临床试验NCT02058225），我们已经获得了。研究母亲膳食营养摄入如何影响健康足月婴儿大脑的综合数据 2019-2020 年，我们还收集了出生后前 3 个月的健康状况。调查问卷显示，这些孩子正处于学龄初期，我们的数据分为两大类。我们的数据包括：（1）人口统计数据。父母和婴儿；（2）母亲饮食营养摄入频率调查问卷（FFQ）哺乳期，已转化为 73 种营养素；(3) 母乳喂养模式（母乳或配方奶，或母乳喂养） (4) 家长的社会经济状况和生活方式调查问卷； (5) 母乳营养； (6) 母体黄斑色素眼密度 (MPOD)，这是一种易于获得的定量指标。 (7) 婴儿脑 MRI（结构、扩散、功能）1 出生后 3 个月；(8) 反映 3 个月时神经认知功能（例如运动）的婴儿 Mullen 评分； (9)学龄早期（4-6岁）神经认知问卷和转换后的神经认知评分。我们建议组织数据（目标 1），处理和协调多站点 MRI（目标 2），并公开发布这些很难获得的综合数据（目标 3）可以帮助研究饮食和母乳之间的关系。营养与婴儿早期的大脑结构和功能有关，以及它们与学龄的关系神经认知，以及它们如何与社会经济地位和人口因素相互作用。