THYROXINE EFFECTS ON DYSTROPHIC MUSCLES

甲状腺素对营养不良性肌肉的影响

• 批准号: 2082207
• 负责人: YADHU N SINGH
• 金额: $ 10.4万
• 依托单位: SOUTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1999-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2082207
• 关键词: cations; diaphragm; disease /disorder model; hamsters; histochemistry /cytochemistry; hormone regulation /control mechanism; hypercapnia; hypoventilation; lung alveolus; muscle contraction; muscular dystrophy; thyroid hormones; thyroxine; cations; diaphragm; disease /disorder model; hamsters; histochemistry /cytochemistry; hormone regulation /control mechanism; hypercapnia; hypoventilation; lung alveolus; muscle contraction; muscular dystrophy; thyroid hormones; thyroxine

DESCRIPTION: (adapted from Applicant's Abstract) Alveolar hypoventilation (AH) occurs when the elimination of metabolic CO2 is outpaced by its production. It is a common feature of neuromuscular disease that leads to cardiac and skeletal muscle dysfunction. The BIO 14.6 hamster (DH) is a useful animal model that displays AH. Studies indicate that DH display pathological changes in the gross and microscopic morphology, histochemistry, cation content and contractility in the diaphragm, which are consistent with the slowly evolving inability of the animal to increase tidal volume and minute ventilation in response to a hypercapnic challenge. AH is also associated with low serum levels of triiodothyronine (T3) and thyroxine (T4). The investigators recently showed that T4 treatment slows down the progression of dystrophic features in DH and improves ventilatory responses to hypoxia and hypercapnia. The purpose of this project is to determine whether T4 replacement in DH improves ventilation by preventing morphological degeneration and histochemical changes in the diaphragm and how these changes correlate with serum thyroid hormone levels, cation content and improved contractility.

描述：（改编自申请人的摘要）肺泡 当消除代谢CO2为 超过其生产。 这是神经肌肉的共同特征 导致心脏和骨骼肌功能障碍的疾病。 生物 14.6仓鼠（DH）是显示AH的有用动物模型。 研究 表明DH显示出病理变化，并且 微观形态，组织化学，阳离子含量和收缩力 在隔膜中，与缓慢发展一致 动物无法增加潮汐量和微小通风 应对超含量挑战。 AH也与低相关 三碘甲状腺素（T3）和甲状腺素（T4）的血清水平。 这 研究人员最近表明，T4治疗减慢了 DH中营养不良特征的进展并改善通风 对缺氧和高碳酸盐的反应。 这个项目的目的是 确定DH中的T4更换是否可以通过 防止形态学变性和组织化学变化 隔膜以及这些变化如何与血清甲状腺激素相关 水平，阳离子含量和提高的收缩率。