PROSPECTIVE STUDY OF ENTERIC INFECTIONS IN BEDOUIN CHILDREN

贝都因儿童肠道感染的前瞻性研究

• 批准号: 5205173
• 负责人: DRORA FRASER
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5205173
• 关键词: Escherichia coli infections; Israel; body physical characteristic; child (0-11); cryptosporidiosis; data collection; diarrhea; disease /disorder proneness /risk; gastrointestinal infection; giardiasis; health education; human subject; infant human (0-1 year); infant mortality; virulence

A cohort of 240 Bedouin infants will be followed from birth to age two years, to examine the environmental, agent and host characteristics, and the interactions between them, leading to the range of clinical manifestation observed in Giardia lamblia (GL), Cryptosporidium (CR), and E. coli infections. Using novel methods of detection which are more sensitive than the methods available to date we will be able to define the factors causing GL infection in infants and children to be non- pathogenic in endemic areas. The factors to be examined include age at first exposure, intensity and frequency of repeat exposures, the nutritional status of the infants, previous diarrheal disease, passive immunity acquired through breast feeding, the immunological status of the infants, both humoral and cellular, and the characteristics of Giardia strains. The project will examine how GL carriage modulates and diminishes infections with other enteric pathogens, or their clinical manifestations. We will also determine why CR infections, on the other hand, often lead to persistent diarrhea. Possible explanations sought will include subnormal immunologic status, inadequate immunologic response associated with deficient nutritional status, high frequency of infections in general, or infections with multiple enteric agents, in particular. In the proposed program we will also have a unique opportunity to examine in a Middle-Eastern population, with diarrheal disease patterns of developing nations, the role of different categories of E. coli, thus contributing knowledge essential for the development of new vaccines. Another major contribution of this project is the demonstration, using a controlled intervention trial, that rates of enteric infections in infants and young children living in semi-urban settlements, in suboptimal environmental conditions, can be lowered by educational intervention methods aimed at reducing the direct exposure of the children and their food to enteric organisms. The intervention methods used will be transferable to other newly urbanized high risk populations.

从出生到2岁 多年，检查环境，代理和寄宿特征，以及 它们之间的相互作用，导致临床的范围 在贾第鞭毛虫（GL），隐孢子虫（CR）和 大肠杆菌感染。 使用新的检测方法 比迄今为止可用的方法敏感我们能够定义 导致婴儿和儿童的GL感染的因素非 - 流行地区的致病性。 要检查的因素包括年龄 重复暴露的第一次暴露，强度和频率， 婴儿的营养状况，以前的腹泻病，被动 通过母乳喂养获得的免疫力， 婴儿和细胞的婴儿以及贾第鞭毛虫的特征 菌株。 该项目将检查GL运输方式如何调节和 减少对其他肠道病原体或其临床感染的感染 表现。 我们还将确定为什么CR感染在另一个 手，通常会导致持续的腹泻。 寻求的可能解释 将包括亚正常免疫学位，免疫学不足 与不足的营养状况相关的反应，高频 一般感染或多种肠药感染， 特别的。 在拟议的计划中，我们还将有一个独特的 有机会在中东人群中进行检查，腹泻 发展中国家的疾病模式，不同类别的作用 大肠杆菌，从而为发展提供了必不可少的知识 新疫苗。 该项目的另一个主要贡献是 示范，使用对照干预试验的速度 居住在半城市的婴儿和幼儿的肠道感染 在次优的环境条件下的定居点可以降低 旨在减少直接暴露的教育干预方法 儿童及其食物给肠子生物。 干预 所使用的方法将转移到其他新的城市化高风险 人群。