Socio-spatial Networks and Tuberculosis Infection in Youth in Rural Uganda

乌干达农村青年的社会空间网络与结核病感染

基本信息

批准号：
10515642
负责人：
Carina Marquez
金额：
$ 67.56万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-11-16 至 2025-10-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10515642
关键词：
17 year old Address Adolescence Adolescent Adult Africa Africa South of the Sahara Age Age Years Baseline Surveys Biological Assay Case/Control Studies Characteristics Child Cohort Studies Communities Data Disease Epidemic Epidemiology HIV Home Hour Household Incidence Infection Intervention Interview Investigation Knowledge Life Cycle Stages Location Longitudinal cohort study Measurement Measures Methodology Methods Molecular Epidemiology Network-based Outcome Pathway Analysis Persons Population Prevalence Research Infrastructure Role Rural Rural Community School-Age Population Social Network Socialization Source Structure Surveys Techniques Television Testing Time Tuberculin Test Tuberculosis Uganda Variant Work Youth age group age stratification burden of illness case finding cohort density design early childhood epidemiology study human old age (65+)insight novel novel strategies population based preference prospective rural area scale up secondary analysis sex social therapy design transmission process young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The burden of tuberculosis (TB) in children and adolescents is massive and current TB control strategies, even at full scale-up, are insufficient to address it.4,6-8,10 Novel strategies to expand TB control outside of the home and into the community, where children acquire an estimated 80% of new TB infections,11-12 are urgently needed. However, an incomplete understanding of where and from whom youth acquire TB, and how these drivers change throughout the early life-course, hampers the design of novel interventions. Thus, we propose the first-ever population-representative, longitudinal TB Infection Incidence Cohort of youth ages 1 to 18 years, in rural communities in Uganda. Using a combination of epidemiologic and network analytic techniques, this study will address key foundational knowledge gaps about TB transmission within 3 socio-spatial networks of youth: the household network, the non-household social network (close contacts), and the network of casual contacts encountered in community venues. In Aim 1 we will characterize the role of the household social network in TB infection throughout the early life course. In Aim 2 we will employ social network analysis to assess the relationships between child and adolescent TB infections and their community-based social network, and in Aim 3 we will use location-based networks to assess the relationships between community venues and incident TB infections in youth. Data from this proposal will directly inform novel, age-specific, community-based TB control strategies and will help optimize existing household-based strategies.

项目概要/摘要儿童和青少年的结核病 (TB) 负担巨大，当前的结核病控制策略甚至全面扩大规模，不足以解决这个问题。4,6-8,10 将结核病控制扩大到家庭以外的新策略并进入社区，估计 80% 的新结核感染病例都是由儿童感染的，11-12 需要。然而，对于青少年在哪里、从谁那里感染结核病以及如何感染结核病，我们还没有完全了解。驱动因素在整个早期生命历程中都会发生变化，阻碍了新颖干预措施的设计。因此，我们建议有史以来第一个具有人口代表性的纵向 1 至 18 岁青少年结核感染发病率队列，在乌干达的农村社区。结合流行病学和网络分析技术，研究将解决结核病在 3 个社会空间网络内传播的关键基础知识差距青年：家庭网络、非家庭社交网络（密切接触者）、休闲网络在社区场所遇到的接触者。在目标 1 中，我们将描述家庭社会的角色整个早期生命过程中结核病感染的网络。在目标 2 中，我们将利用社交网络分析来评估儿童和青少年结核病感染与其社区社交之间的关系网络，在目标 3 中，我们将使用基于位置的网络来评估社区之间的关系场所和青少年结核病感染事件。该提案中的数据将直接告知新颖的、特定年龄的、基于社区的结核病控制战略，并将有助于优化现有的基于家庭的战略。