Legacy of Obesity on Influenza and Coronavirus
肥胖对流感和冠状病毒的影响
基本信息
- 批准号:10516073
- 负责人:
- 金额:$ 9.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-11-01 至 2023-10-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVACE2AdolescentAdultBiological MarkersBiological ModelsBody Weight decreasedBody mass indexCOVID-19CellsChildCoronavirusCountryDiseaseEthnic PopulationFatty acid glycerol estersFemaleFollow-Up StudiesGoalsHealthHemagglutinationImmuneImmune responseImmunizationImmunizeInfectionInflammationInfluenzaInfluenza vaccinationInterventionKnowledgeLeptinLinkMetabolicMetabolic syndromeModelingMusObese MiceObesityOverweightPersonsPhenotypePopulationPredispositionPrevalencePreventionPrognostic MarkerRisk FactorsSARS-CoV-2 infectionSeverity of illnessTestingThinnessTimeTransgenic MiceUnderweightUnited StatesVaccinatedVaccinationVaccinesVariantViralVirusWorld Health Organizationadiponectinadult obesitydiet-induced obesitydietary controlefficacy evaluationepidemiologic datafluhealthy weighthigh riskimmunogenicityimprovedinfluenza infectioninfluenzavirusinnovationmalemetabolic phenotypemouse modelnovelobese personobesity in childrenracial populationseroconversionsocioeconomicssurvival outcomevaccine efficacyvaccine platformvaccine responseviral transmissionweight loss program
项目摘要
OVERALL ABSTRACT
We and others have demonstrated that obesity results in enhanced disease severity, prolonged transmission
of viral variants and increased susceptibility to infection. While vaccines remain our best prevention,
vaccination is less effective in overweight/obese people resulting in vaccinated obese adults being twice as
likely to develop flu than healthy weight people. Using our newly developed weight loss program for diet-
induced obese (DIO) mice, our preliminary studies suggest that weight loss following flu vaccination does
not improve protection. While switching from a high fat to lean control diet effectively reduced weight and
returned key metabolic biomarkers to a set baseline, this did not improve survival outcomes. These findings
have dramatic ramifications considering that the World Health Organization (WHO) predicts that most of the
world’s population lives in countries where being overweight and obese is more prevalent than being
underweight.
Obesity is more than a BMI number. The overall goals of these studies are to determine if the metabolic
state at the time of vaccination or infection, rather than BMI, are tightly correlated with immunogenicity and
protection from influenza virus and SARS-CoV-2 infection/vaccination. We hypothesize that metabolic health at
the time of immunization or infection and not BMI, correlates with protective immune responses against
influenza virus and SARS-CoV-2. To test this hypothesis, we have developed the following specific aims:
1. Demonstrate that improved metabolic health at the time of influenza vaccination or infection enhances
efficacy and immunogenicity.
2. Define the legacy of obesity on SARS-CoV-2 infection and vaccination.
With rates of childhood obesity and metabolic syndrome independent of obesity, predicted to exponentially
increase over the next 50 years, it is imperative that we develop strategies to better protect this growing
population. If successful, our studies will link metabolic biomarkers to vaccine/infection immunogenicity and
identify novel correlates of protection. Follow up studies will identify vaccine platforms or intervention strategies
that overcome poor metabolic health. Our innovative studies extend beyond influenza and COVID-19 and are
likely to apply to a wide variety of infections/vaccinations.
总体摘要
我们和其他人已经证明,肥胖会导致疾病严重程度增加、传播时间延长
虽然疫苗仍然是我们最好的预防措施,
疫苗接种对超重/肥胖人群的效果较差,导致肥胖成年人的患病率是成年人的两倍
使用我们新开发的饮食减肥计划,比健康体重的人更容易患流感。
诱导性肥胖(DIO)小鼠,我们的初步研究表明,流感疫苗接种后体重减轻确实
虽然从高脂肪饮食转向瘦肉控制饮食有效地减轻了体重,但并没有提高保护作用。
将关键代谢生物标志物恢复到设定的基线,但这并没有改善生存结果。
考虑到世界卫生组织 (WHO) 预测大多数
世界人口生活在超重和肥胖比肥胖更普遍的国家
体重不足。
肥胖不仅仅是体重指数,这些研究的总体目标是确定代谢是否正常。
接种疫苗或感染时的状态,而不是体重指数,与免疫原性密切相关,并且
预防流感病毒和 SARS-CoV-2 感染/疫苗接种 我们寻求代谢健康。
免疫或感染的时间而不是体重指数,与针对病毒的保护性免疫反应相关
为了检验这一假设,我们制定了以下具体目标:
1. 证明在接种流感疫苗或感染时代谢健康的改善可以增强
功效和免疫原性。
2. 明确肥胖对 SARS-CoV-2 感染和疫苗接种的影响。
与肥胖无关的儿童肥胖和代谢综合征的发病率预计呈指数级增长
随着未来 50 年的增长,我们必须制定战略来更好地保护这一不断增长的
如果成功,我们的研究将把代谢生物标志物与疫苗/感染免疫原性和
确定新的保护相关性 后续研究将确定疫苗平台或干预策略。
我们的创新研究不仅限于流感和 COVID-19,而且还克服了不良的代谢健康问题。
可能适用于多种感染/疫苗接种。
项目成果
期刊论文数量(0)
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Stacey L Schultz-Cherry其他文献
Stacey L Schultz-Cherry的其他文献
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{{ truncateString('Stacey L Schultz-Cherry', 18)}}的其他基金
2020 Biology of Acute Respiratory Infection Gordon Research Conference and Gordon Research Seminar
2020急性呼吸道感染生物学戈登研究大会暨戈登研究研讨会
- 批准号:
9913675 - 财政年份:2020
- 资助金额:
$ 9.1万 - 项目类别:
Do they or don't they: astrovirus-induced diarrhea
是还是不是:星状病毒引起的腹泻
- 批准号:
9804141 - 财政年份:2018
- 资助金额:
$ 9.1万 - 项目类别:
Beyond model development: murine astrovirus endogenous pathogens of laboratory mice
超越模型开发:实验小鼠的鼠星状病毒内源性病原体
- 批准号:
9165329 - 财政年份:2016
- 资助金额:
$ 9.1万 - 项目类别:
Lethality of H5N1 Influenza Virus is Linked to TGF-beta
H5N1 流感病毒的致死率与 TGF-β 有关
- 批准号:
6866040 - 财政年份:2005
- 资助金额:
$ 9.1万 - 项目类别:
Lethality of H5N1 Influenza Virus is Linked to TGF-beta
H5N1 流感病毒的致死率与 TGF-β 有关
- 批准号:
7388294 - 财政年份:2005
- 资助金额:
$ 9.1万 - 项目类别:
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